Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Matthew W. Segar, Sumitabh Singh, Gordon Reeves, Christopher O'Connor, Ileana Pina, David Whellan, William Kraus, Robert Mentz, Dalane Kitzman
Summary: This study investigates the impact of baseline frailty on the efficacy of aerobic exercise training in patients with heart failure. The results show that aerobic exercise training significantly reduces the risk of all-cause hospitalization in frail patients, but the effect is not significant for non-frail patients.
Article
Medicine, General & Internal
Maurizio Volterrani, Giuseppe Caminiti, Marco Alfonso Perrone, Anna Cerrito, Alessio Franchini, Vincenzo Manzi, Ferdinando Iellamo
Summary: The effectiveness of concurrent exercise training program in patients with chronic heart failure was evaluated. The study showed that concurrent training resulted in significant improvements in functional capacity and muscular strength, compared to single-mode aerobic training, without major side effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Pieter Martens, Silvio N. Augusto, J. Emanuel Finet, W. H. Wilson Tang
Summary: Noncardiac comorbidities significantly affect exercise capacity and functional status in patients with chronic heart failure, with certain clusters of comorbidities having a more pronounced impact on outcomes. The type and burden of NCCs in HF patients play a crucial role in determining clinical outcomes and the response to aerobic exercise training.
JACC-HEART FAILURE
(2023)
Review
Health Care Sciences & Services
Mieke H. J. Schulte, Jiska J. Aardoom, Lisa Loheide-Niesmann, Leonie L. L. Verstraete, Hans C. Ossebaard, Heleen Riper
Summary: This review investigates the effects of eHealth interventions on medication adherence in patients with COPD or asthma. The results show mixed effects, possibly due to the type, context, and intensity of the interventions, as well as differences in the operationalization and measurement of adherence outcomes. Further research is needed to fully understand the potential of eHealth in optimizing treatment adherence for COPD and asthma.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Pharmacological interventions have shown limited efficacy, while exercise-based interventions consistently improve symptoms and quality of life. This may be attributed to the pleiotropic effects of exercise, which positively influence the various abnormalities contributing to exercise intolerance in HFpEF. This article critically examines the effects of exercise-based therapies, compares them with other cardiovascular conditions, and highlights gaps in implementation for future research.
Article
Medicine, Research & Experimental
Giuseppe Potrick Stefani, Lucas Capalonga, Lucas Ribeiro da Silva, Thiago Gomes Heck, Matias Nunes Frizzo, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Diovana de Batista, Samlai Vedovatto, Ana Paula Santin Bertoni, Marcia Rosangela Wink, Pedro Dal Lago
Summary: The study found that combined exercise training (CET) with 13-alanine and L-histidine supplementation in rats with heart failure (HF) can improve functional capacity and biochemical variables, reduce oxidative stress and inflammation, and affect mRNA expression of calcium transporters in the skeletal muscle.
Article
Cardiac & Cardiovascular Systems
Arlana G. Taylor, Andrew I. Ignaszewski, Shannon S. D. Bredin, John S. Hill, Erin M. Shellington, Darren E. R. Warburton
Summary: This study aimed to evaluate the acute inflammatory response in patients with chronic heart failure (CHF) following steady state (SS) or high intensity interval training (HIIT). The results showed that a single bout of HIIT or SS did not result in excessive inflammatory activation in CHF patients, and both types of exercise had similar effects on inflammatory markers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Vandana Sachdev, Kavita Sharma, Steven J. Keteyian, Charina F. Alcain, Patrice Desvigne-Nickens, Jerome L. Fleg, Viorel G. Florea, Barry A. Franklin, Maya Guglin, Martin Halle, Eric S. Leifer, Gurusher Panjrath, Emily A. Tinsley, Renee P. Wong, Dalane W. Kitzman
Summary: HFpEF is a common form of heart failure with increasing prevalence and worsening outcomes. Exercise-based interventions have shown significant improvements in symptoms, exercise capacity, and quality of life. The pleiotropic effects of exercise may contribute to these improvements by addressing the various abnormalities that contribute to exercise intolerance in HFpEF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine R. Collins, Gordon Reeves, Nancy Houston J. Miller, David M. Whellan, Christopher H. O'Connor, Bess W. Marcus, Dalane E. Kitzman, William Kraus, HF ACTION Invest
Summary: The purpose of this analysis was to identify baseline clinical and demographic characteristics predicting exercise training adherence in the HF-ACTION study cohort. The results showed that younger age, lower income, more severe mitral regurgitation, shorter 6-min walk test distance, lower exercise capacity, and Black or African American race were associated with poorer exercise intervention adherence. However, these characteristics had very limited predictive contribution to adherence.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Peter H. Brubaker, Barbara J. Nicklas, Denise K. Houston, W. Gregory Hundley, Haiying Chen, Anthony J. A. Molina, W. Mary Lyles, Benjamin Nelson, Bharathi Upadhya, Russell Newland, Dalane W. Kitzman
Summary: This study aimed to investigate whether adding resistance training (RT) to combined caloric restriction (CR) and aerobic exercise training (AT) can reduce skeletal muscle loss and further improve outcomes in older obese heart failure patients. The results showed that adding RT to CR+AT increased leg muscle strength and quality, but did not reduce skeletal muscle and weight loss, or further increase VO2peak or quality-of-life.
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Mattia Lunardi, Sijing Wu, Patrick W. Serruys, Yoshinobu Onuma, Osama Soliman, William Wijns, Wilfried Mullens, Faisal Sharif
Summary: More than half of heart failure patients also have pulmonary hypertension, which affects symptoms and prognosis. The role of exercise in this patient population is still unclear due to a lack of clear understanding of the relationship between exercise and changes in pulmonary artery pressure and symptoms. The limited evidence on this topic is contradictory and difficult to compare due to different exercise programs and assessment techniques. The different classes of heart failure further complicate the assessment of exercise effects on outcomes. Future studies using advanced technologies may provide more insights into the effects of exercise training in heart failure patients with pulmonary hypertension.
Review
Cardiac & Cardiovascular Systems
Heather L. Wheat, Savitri Fedson, Biykem Bozkurt, Richard A. Josephson
Summary: Exercise intolerance is common in heart failure patients, and cardiac rehabilitation has shown significant benefits in improving mortality and quality of life. However, the benefits of exercise therapy may vary depending on the underlying disease phenotype.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Massimo Gulizia, Francesco Orso, Andrea Mortara, Donata Lucci, Nadia Aspromonte, Leonardo De Luca, Giuseppe Di Tano, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Furio Colivicchi, Andrea Di Lenarda, Fabrizio Oliva
Summary: This study assessed adherence to guideline recommendations among Italian cardiology sites in the management of acute and chronic heart failure, and found that an educational intervention could improve their performance on specific indicators.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Patricia F. Trevizan, Ligia M. Antunes-Correa, Denise M. L. Lobo, Patricia A. Oliveira, Dirceu R. de Almeida, Maria Cristina D. Abduch, Wilson Mathias Junior, Ludhmila Abrahao Hajjar, Roberto Kalil Filho, Carlos Eduardo Negrao
Summary: The study found that combined inspiratory muscle training and aerobic exercise training did not have more pronounced effects on neurovascular control in patients with heart failure with reduced ejection fraction compared to aerobic exercise training alone.
Article
Cardiac & Cardiovascular Systems
Ignatios Ikonomidis, John Thymis, Panagiotis Simitsis, Georgia-Angeliki Koliou, Spiridon Katsanos, Charilaos Triantafyllou, Foteini Kousathana, George Pavlidis, Aikaterini Kountouri, Eftihia Polyzogopoulou, Konstantinos Katogiannis, Dimitrios Vlastos, Gavriella Kostelli, Helen Triantafyllidi, John Parissis, Evangelia Papadavid, John Lekakis, Gerasimos Filippatos, Vaia Lambadiari
Summary: The study found that disturbance of glycocalyx integrity is related to increased cardiovascular risk. Higher PBRS-25 values predicted a higher risk for MACE, and adding PBRS-25 to predictive models improved their accuracy in predicting cardiovascular events. Glycocalyx integrity serves as an independent and additive predictor to traditional risk factors for MACE at a 6-year follow-up in individuals without cardiovascular disease.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Ignatios Ikonomidis, George Pavlidis, Nikolaos Kadoglou, George Makavos, Konstantinos Katogiannis, Aikaterini Kountouri, John Thymis, Gavriella Kostelli, Irini Kapniari, Konstantinos Theodoropoulos, John Parissis, Pelagia Katsimbri, Evangelia Papadavid, Vaia Lambadiari
Summary: The phosphodiesterase 4 inhibitor apremilast has significant effects on endothelial glycocalyx, vascular, and myocardial function in the treatment of psoriasis. It restores glycocalyx integrity and confers greater improvement in vascular and myocardial function compared to anti-tumor necrosis factor-alpha or cyclosporine.
Article
Cardiac & Cardiovascular Systems
Ignatios Ikonomidis, John Thymis, Kallirhoe Kourea, Gavriella Kostelli, Antria Neocleous, Konstantinos Katogiannis, George Makavos, Eftihia Polyzogopoulou, Panagiotis Plotas, Vaia Lambadiari, John Parissis
Summary: The Fagerstrom score is a useful predictor of smoking cessation in AMI patients. Patients who participate in smoking cessation programs have lower relapse rates.
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Emmanouil Korakas, Theodoros Argyropoulos, Georgia-Angeliki Koliou, Aristofanis Gikas, Aikaterini Kountouri, Stavroula Kostaridou Nikolopoulou, Panagiotis Plotas, Konstantinos Kontoangelos, Ignatios Ikonomidis, Nikolaos P. E. Kadoglou, Athanasios Raptis, Vaia Lambadiari
Summary: This is the first report on the prevalence of stress hyperglycemia in pediatric patients in Greece. Asthma, corticosteroids, and beta 2-agonists significantly increase the risk of stress hyperglycemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ignatios Ikonomidis, George Pavlidis, Maria Tsoumani, Foteini Kousathana, Konstantinos Katogiannis, Damianos Tsilivarakis, John Thymis, Aikaterini Kountouri, Emmanouil Korakas, Loukia Pliouta, Athanasios Raptis, John Parissis, Ioanna Andreadou, Vaia Lambadiari
Summary: Oxidative stress plays a significant role in the pathogenesis of diabetes. This study found that nitrite/nitrate levels decreased, perfused boundary region increased, and coronary flow reserve and left ventricular global longitudinal strain decreased in subjects with high blood sugar, indicating a correlation with insulin resistance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Ioanna Koniari, Dimitrios Velissaris, Nicholas G. Kounis, Eleni Koufou, Eleni Artopoulou, Cesare de Gregorio, Virginia Mplani, Themistoklis Paraskevas, Grigorios Tsigkas, Ming-Yow Hung, Panagiotis Plotas, Vaia Lambadiari, Ignatios Ikonomidis
Summary: Diabetes mellitus and heart failure are chronic disorders that affect millions of people worldwide. Hyperglycemia-induced oxidative stress plays a significant role in the progression of diabetes and its complications. Antidiabetic drugs have various effects on heart failure and oxidative stress in diabetic patients, with some drugs showing potential benefits and others being not recommended.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Vaia Lambadiari, Emmanouil Korakas, Evangelos Oikonomou, Evanthia Bletsa, Aikaterini Kountouri, Athina Goliopoulou, Ignatios Ikonomidis, Gerasimos Siasos
Summary: Capillary leak syndrome is a condition that is often overlooked but can have serious consequences, including hypoalbuminemia and potential death. Endothelial dysfunction plays a key role in cardiovascular disease and chronic inflammation, and these factors are also associated with adverse outcomes in COVID-19. This review highlights the importance of cardiovascular risk factors in maintaining endothelial integrity and the potential link between endothelial damage and poor prognosis in COVID-19 patients with hypoalbuminemia.
Article
Cardiac & Cardiovascular Systems
Helen Triantafyllidi, Dionyssia Birmpa, Ignatios Ikonomidis, Dimitrios Benas, George Makavos, Dennis V. Cokkinos, Filippos Triposkiadis, Efstathios K. Iliodromitis
Summary: This study aimed to evaluate the myocardial deformation indices (MDI) at rest and their response at peak exercise during the same CPET session in DCM patients and investigate their relationship with exercise capacity and ventilatory sufficiency. The results showed that resting MDI were impaired but improved at peak exercise, and all MDI at rest and/or peak exercise were related to several CPET-derived parameters. Peak exercise MDI were independently related to exercise capacity and ventilatory efficiency, indicating their potential as predictors of future cardiovascular events in DCM patients.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ignatios Ikonomidis, John Thymis, Georgia-Angeliki Koliou
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Athanasios Triantafyllou, Georgios Papagiannis, Sophia Stasi, Panagiotis Gkrilias, Maria Kyriakidou, Effrosyni Kampouroglou, Apostolos-Zacharias Skouras, Charilaos Tsolakis, George Georgoudis, Olga Savvidou, Panayiotis Papagelopoulos, Panagiotis Koulouvaris
Summary: Chronic nonspecific low back pain (LBP) is associated with lumbar muscle atrophy, diminished strength, stamina, and increased fatigability. Trunk or core stability, provided by the performance and coordination of trunk muscles, is essential in evaluating patients with LBP. The prone plank bridge test (PBT), side bridge test (SBT), and supine bridge test (SUBT) are frequently prescribed tests for assessing core body muscles. This study measured the lumbar spine ranges of motion during the execution of these tests and found statistically significant differences in kinematic patterns between healthy subjects and LBP patients. The results suggest that these tests can be transformed into objective biomechanical diagnostic tools for assessing the efficacy of rehabilitation programs for LBP.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
George Pavlidis, Damianos Tsilivarakis, Konstantinos Katogiannis, Dimitrios Vlastos, Spyridon Katsanos, Eleni Katsanaki, John Thymis, John Parissis, Vaia Lambadiari, Ignatios Ikonomidis
Summary: This study found that aortic stiffness during acute ST-segment elevation myocardial infarction is associated with long-term left ventricular remodelling.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Aikaterini Kountouri, Emmanouil Korakas, Eirini Maratou, Ignatios Ikonomidis, Konstantinos Balampanis, Stavros Liatis, Nikolaos Tentolouris, Panagiotis Toulas, Foteini Kousathana, Christophoros Giatzakis, George D. D. Dimitriadis, Vaia Lambadiari
Summary: This study observed 39 Greek patients with FPLD and found that most patients' genetic mutations were not associated with the lipodystrophic phenotype. However, treatment with metreleptin significantly improved glycemic and lipidemic control in some patients. Further large-scale studies are needed to understand the genetic and allelic heterogeneity of the disease and predict treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Paraskevi C. Fragkou, Ignatios Ikonomidis, Dimitrios Benas, Dimitra Kavatha, Charalampos D. Moschopoulos, Konstantinos Protopapas, Gavriella Kostelli, John Thymis, Dionysia Mpirmpa, Irene Galani, Maria Tsakona, Chrysanthi Oikonomopoulou, George Theocharous, Vassilis G. Gorgoulis, Parisis Gallos, Sotirios Tsiodras, Anastasia Antoniadou, Antonios Papadopoulos, Helen Triantafyllidi
Summary: This study conducted a prospective cohort study on treatment-naive people living with HIV and found that the integrity of endothelial glycocalyx (EG) improved with antiretroviral treatment. This has important implications for the diagnosis and treatment of cardiovascular disease in people living with HIV.
Review
Cardiac & Cardiovascular Systems
Ioanna Koniari, Andreas Gerakaris, Nicholas Kounis, Dimitrios Velissaris, Archana Rao, Mark Ainslie, Ahmed Adlan, Panagiotis Plotas, Ignatios Ikonomidis, Virginia Mplani, Ming-Yow Hung, Cesare de Gregorio, Theofilos Kolettis, Dhiraj Gupta
Summary: This review examines the literature on the use of atrioventricular node ablation and pacing in heart failure and atrial fibrillation patients. It shows that this strategy improves symptoms and cardiac performance, but may have complications such as worsening heart failure, arrhythmias, and sudden death. Cardiac resynchronization therapy is the optimal treatment, while His bundle pacing and left bundle branch pacing are potential alternatives.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Chemistry, Medicinal
Nikolaos Iakovis, Ignatios Ikonomidis, Ioanna Andreadou, Andrew Xanthopoulos, Aikaterini Chamaidi, Nikolaos Chrysakis, Grigorios Giamouzis, John Skoularigis, Ioulia Tseti, Filippos Triposkiadis
Summary: Short-term use of OE enriched with HT showed a trend towards improvement of LV diastolic function and arterial elastic properties in chronic CAD patients, suggesting potential benefits for cardiovascular function.
JOURNAL OF MEDICINAL FOOD
(2023)