Article
Biology
Rosario Statello, Stefano Rossi, Francesco Pisani, Matteo Bonzini, Roberta Andreoli, Agnese Martini, Monica Puligheddu, Pierluigi Cocco, Michele Miragoli
Summary: This study found altered cardiac autonomic regulation in patients with obstructive sleep apnea (OSA) during nighttime and suggested that nighttime HRV could potentially be used as a predictor of sleep breathing disorders. These findings have important clinical implications for the diagnosis and prognosis of OSA.
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Medicine, General & Internal
Hao Cui, Hartzell Schaff, Virend K. Somers, Rick A. Nishimura, Joseph A. Dearani, Jeffrey B. Geske, Katherine S. King, Steve R. Ommen
Summary: In patients with hypertrophic cardiomyopathy, more than half were found to have sleep-disordered breathing, which was mainly associated with aging, overweight, and male sex. However, sleep-disordered breathing did not impact survival following septal myectomy.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Enric Sanchez, Esther Sapina-Beltran, Ricard Gavalda, Ferran Barbe, Gerard Torres, Ariadna Sauret, Mireia Dalmases, Carolina Lopez-Cano, Liliana Gutierrez-Carrasquilla, Marcelino Bermudez-Lopez, Elvira Fernandez, Francisco Purroy, Eva Castro-Boque, Cristina Farras-Salles, Reinald Pamplona, Didac Mauricio, Cristina Hernandez, Rafael Simo, Albert Lecube, ILERVAS Project Collaborators
Summary: The study found that individuals in the prediabetes stage exhibited higher abnormal sleep breathing parameters compared to those with normal glucose metabolism, with a significant increase in apnea events and hypoxemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Tiffany T. Pham, Shanlee M. Davis, Suhong Tong, Khaled A. Campa, Norman R. Friedman, Sarah A. Gitomer
Summary: A retrospective cross-sectional study found a high prevalence of obstructive sleep-disordered breathing (oSDB) in young patients with Turner syndrome (TS), with a four-fold increased risk compared to the general pediatric population. Risk factors for oSDB in TS included adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit. Screening for oSDB and performing polysomnography in TS patients with associated risk factors and symptoms is crucial due to the potential exacerbation of behavioral problems, neurocognitive deficits, and growth impairment associated with oSDB.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Critical Care Medicine
Ankit Parekh, Thomas M. Tolbert, Anne M. Mooney, Jaime Ramos-Cejudo, Ricardo S. Osorio, Marcel Treml, Simon-Dominik Herkenrath, Winfried J. Randerath, Indu Ayappa, David M. Rapoport
Summary: This study derives an automated breath-by-breath probability of obstruction using hallmarks of upper airway obstruction visible on clinical sleep studies, to assist in determining the type of sleep apnea in individuals. Results show that the breath-by-breath probability of obstruction can reliably predict the overall burden of obstructed breaths in individual subjects.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Environmental Sciences
Junyi Wang, Wanzhou Wang, Wenlou Zhang, Jianli Wang, Yongwei Huang, Zixuan Hu, Yahong Chen, Xinbiao Guo, Furong Deng, Liqiang Zhang
Summary: This study aimed to assess the joint effect of multiple air pollutants on sleep disordered breathing parameters and identify the dominant pollutants. The results showed significant associations between air pollutants and sleep disordered breathing parameters in patients with obstructive sleep apnea (OSA), with PM10 and O3 being the dominant pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Norman R. Friedman, Maxene Meier, Kaitlyn Tholen, Renee Crowder, Regina Hoefner-Notz, Thanh Nguyen, Sarah Derieg, Kristen Campbell, Lisa McLeod
Summary: The study found that children who do not require oxygen beyond 3 hours after surgery and pass a sleep room air challenge are safe for discharge regardless of age, obesity status, asthma diagnosis, and obstructive apnea/hypopnea index. Further research is needed to confirm these findings.
Article
Clinical Neurology
Jasneek Chawla, Margaret-Anne Harris, Robert Black, Marie-Josee Leclerc, Hannah Burns, Karen A. Waters, Anne Bernard, Kurt Lushington, Helen Heussler
Summary: This study compared neurocognitive and behavioral data in preschool children with symptomatic OSA and PS at recruitment, finding no significant differences between the two groups. The study suggests that symptoms and behavioral disturbances should be considered in addition to OAHI when determining the need for treatment.
SLEEP AND BREATHING
(2021)
Article
Clinical Neurology
Francisco Alves de Sousa, Marta Rios Pinho, Ana Nobrega Pinto, Miguel Bebiano Coutinho, Alberto Caldas Afonso, Manuel Ferreira Magalhaes
Summary: Paediatric obstructive sleep disordered breathing (OSDB) has significant effects on cardiovascular physiology and metabolism. This study aimed to estimate the metabolism of paediatric OSDB at rest and during exercise. The results showed that children with OSDB had higher resting heart rate, oxygen consumption, and energy expenditure compared to controls. They also had lower maximal oxygen consumption and energy expenditure during exercise. The increment of oxygen consumption and energy expenditure with exercise was lower in children with OSDB.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Critical Care Medicine
Ablo Prudence Wachinou, Corinne Houehanou, Serge Ade, Terence Totah, Mathieu Berger, Geoffroy Solelhac, Salmane Amidou, Attanon Arnauld Fiogbe, Frederic Alovokpinhou, Philipe Lacroix, Pierre-Marie Preux, Pedro Marques-Vidal, Gildas Agodokpessi, Dismand Houinato, Raphael Heinzer
Summary: The study conducted a large-scale evaluation of the prevalence of sleep-disordered breathing and associated factors in a general population in Benin, west Africa. The high prevalence of SDB identified in the study should encourage the development of public health policies to address and manage this condition in African countries.
LANCET RESPIRATORY MEDICINE
(2022)
Review
Clinical Neurology
Janna R. Raphelson, Kimberly Y. Kreitinger, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a common condition with significant neurocognitive and cardiovascular effects. Positive airway pressure (PAP) therapy can help prevent airway collapse and improve oxygen levels, carbon dioxide levels, and sleep quality. While adherence to PAP therapy was once seen as a barrier, in reality, adherence rates are likely higher than commonly believed, with various strategies available to help improve patient adherence.
Article
Multidisciplinary Sciences
Yoshinari Nakatsuka, Kimihiko Murase, Kazuhiro Sonomura, Yasuharu Tabara, Tadao Nagasaki, Satoshi Hamada, Takeshi Matsumoto, Takuma Minami, Osamu Kanai, Hirofumi Takeyama, Hironobu Sunadome, Naomi Takahashi, Isuzu Nakamoto, Kiminobu Tanizawa, Tomohiro Handa, Taka-Aki Sato, Naoko Komenami, Tomoko Wakamura, Satoshi Morita, Osamu Takeuchi, Takeo Nakayama, Toyohiro Hirai, Yoichiro Kamatani, Fumihiko Matsuda, Kazuo Chin
Summary: In this study, researchers identified 20 metabolites related to sleep disordered breathing (SDB) using gas chromatography-mass spectrometry analysis. These metabolites were found to be closely related to fructose metabolism. Further analysis revealed that moderate-severe SDB was a significant factor for increased plasma fructose levels, and CPAP treatment can lower plasma fructose levels.
SCIENTIFIC REPORTS
(2023)
