Article
Medicine, General & Internal
Bartosz Karolak, Michal Ciurzynski, Marta Skowronska, Katarzyna Kurnicka, Magdalena Plywaczewska, Aleksandra Furdyna, Katarzyna Perzanowska-Brzeszkiewicz, Barbara Lichodziejewska, Szymon Pacho, Michal Machowski, Piotr Bienias, Malgorzata Wisniewska, Marek Golebiowski, Piotr Pruszczyk
Summary: In the NOAC era, most low-risk acute pulmonary embolism (APE) patients can be treated at home, but identifying those at very low risk of clinical deterioration may be challenging. This study aimed to propose a risk stratification algorithm for sPESI 0 point APE patients, allowing them to select candidates for safe outpatient treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Article
Medicine, General & Internal
Valentina Mercurio, Hussein J. Hassan, Mario Naranjo, Alessandra Cuomo, Jeremy A. Mazurek, Paul R. Forfia, Aparna Balasubramanian, Catherine E. Simpson, Rachel L. Damico, Todd M. Kolb, Stephen C. Mathai, Steven Hsu, Monica Mukherjee, Paul M. Hassoun
Summary: This study found that echocardiographic parameters can improve the risk stratification of intermediate-risk PAH patients and discriminate distinct survival phenotypes. By measuring TAPSE and degree of TR, intermediate-risk patients can be further stratified into different risk groups, which can potentially guide subsequent therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel Garcia-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Olivier Ayrault, Tobias Goschzik, Torsten Pietsch, Martin Sill, Stefan M. Pfister, Stefan Rutkowski, Stacey Richardson, Rebecca M. Hill, Daniel Williamson, Simon Bailey, Edward C. Schwalbe, Steven C. Clifford, Debbie Hicks
Summary: This study comprehensively characterizes the molecular landscape of pediatric MBGrp4 and determines its utility for clinical management. A novel risk-stratification scheme based on WCA and subgroups is proposed, which improves outcome prediction and redefines risk-status for the majority of MBGrp4 patients.
ACTA NEUROPATHOLOGICA
(2023)
Article
Critical Care Medicine
Anthony J. Weekes, Denise N. Fraga, Vitaliy Belyshev, William Bost, Christopher A. Gardner, Nathaniel S. O'Connell
Summary: In patients with intermediate-risk pulmonary embolism (PE), baseline right ventricle (RV), RV/LV ratio, and RV systolic function measurements are significantly different between those who experience subsequent clinical deterioration and those who do not.
Article
Cardiac & Cardiovascular Systems
C. Sciaccaluga, G. E. Mandoli, N. Ghionzoli, F. Anselmi, C. Sorini Dini, F. Righini, F. Cesareo, F. D'Ascenzi, M. Focardi, S. Valente, M. Cameli
Summary: Cardiogenic shock is a complex and life-threatening condition with high mortality that requires urgent diagnostic assessment and treatment. Early identification of patients who would benefit from more aggressive treatment can facilitate efficient resource allocation.
HEART FAILURE REVIEWS
(2022)
Article
Medicine, General & Internal
Zhenqiang Wu, Anna P. Pilbrow, Oi Wah Liew, Jenny P. C. Chong, John Sluyter, Lynley K. Lewis, Moritz Lasse, Chris M. Frampton, Rod Jackson, Katrina Poppe, Carlos Arturo Camargo, Vicky A. Cameron, Robert Scragg, A. Mark Richards
Summary: Plasma cardiac markers independently and robustly predict increased hazard of incident cardiovascular disease, beyond established risk factors, in community-dwelling populations, as validated in this study.
Article
Cardiac & Cardiovascular Systems
Justin B. Echouffo-Tcheugui, Solomon K. Musani, Alain G. Bertoni, Adolfo Correa, Ervin R. Fox, Robert J. Mentz
Summary: Cluster analysis identified three distinct cardiovascular phenotypes among Blacks with diabetes, with the phenotype characterized by high left ventricular mass and cardiac biomarkers associated with worse prognosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Oncology
Samaneh Eickelschulte, Anja Lisa Riediger, Arlou Kristina Angeles, Florian Janke, Stefan Duensing, Holger Sueltmann, Magdalena Goertz
Summary: Prostate cancer, a heterogeneous disease, lacks accurate diagnostic biomarkers such as prostate-specific antigen. Novel tissue and liquid biopsy biomarkers have emerged, providing potential complementary options for the diagnosis of heterogeneous tumors. Current liquid biopsy approaches offer characteristics of tumors, but the spatial heterogeneity of tumors highlights the need for additional diagnostic and prognostic options.
Article
Medicine, Research & Experimental
Sayoni Das, Krystyna Taylor, James Kozubek, Jason Sardell, Steve Gardner
Summary: This study provides the first detailed genetic insights into the pathophysiological mechanisms underpinning ME/CFS and offers new approaches for better diagnosis and treatment of patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Larisa Anghel, Radu Sascau, Ioana Madalina Zota, Cristian Statescu
Summary: Non-ischemic dilated cardiomyopathy is a myocardial disorder characterized by left ventricular dilatation and systolic impairment, posing an increased risk of sudden cardiac death. Predicting patient prognosis is crucial for individualized treatment, and biomarkers may serve as important tools for risk stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Steven H. J. Hageman, Carmen Petitjaen, Lisa Pennells, Stephen Kaptoge, Romin Pajouheshnia, Taavi Tillmann, Michael J. Blaha, Robyn L. McClelland, Kunihiro Matsushita, Vijay Nambi, Olaf H. Klungel, Patrick C. Souverein, Yvonne T. van der Schouw, W. M. Monique Verschuren, Nils Lehmann, Raimund Erbel, Karl-Heinz Joeckel, Emanuele Di Angelantonio, Frank L. J. Visseren, Jannick A. N. Dorresteijn
Summary: This study aims to develop a new method for predicting heart disease risk by incorporating additional risk factors such as coronary artery calcium (CAC). The researchers found that adding CAC to the existing risk prediction model improved the accuracy of predicted cardiovascular disease (CVD) risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Philippe Taieb, Yishay Szekely, Lior Lupu, Eihab Ghantous, Ariel Borohovitz, Sapir Sadon, Yael Lichter, Yanai Ben-Gal, Ariel Banai, Aviram Hochstadt, Ilan Merdler, Orly Sapir, Yoav Granot, Michal Laufer-Perl, Shmuel Banai, Yan Topilsky
Summary: Cardiovascular involvement is common in COVID-19 patients, with right ventricular dynamics related to easily obtainable clinical parameters, while left ventricular dynamics are independent predictors of mortality, particularly in severe disease.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Biology
Joseph D. Butner, Geoffrey Martin, Zhihui Wang, Bruna Corradetti, Mauro Ferrari, Nestor Esnaola, Caroline Chung, David S. Hong, James W. Welsh, Naomi Hasegawa, Elizabeth A. Mittendorf, Steven A. Curley, Shu-Hsia Chen, Ping-Ying Pan, Steven K. Libutti, Shridar Ganesan, Richard L. Sidman, Renata Pasqualini, Wadih Arap, Eugene J. Koay, Vittorio Cristini
Summary: This study developed a mechanistic mathematical model to understand factors affecting the efficacy of checkpoint inhibitor therapy in cancer patients. The model accurately predicted treatment outcomes based on clinical data, suggesting that model parameters could serve as early and robust biomarkers of treatment efficacy.
Article
Clinical Neurology
Leon Beyer, Hannah Stocker, Dan Rujescu, Bernd Holleczek, Julia Stockmann, Andreas Nabers, Hermann Brenner, Klaus Gerwert
Summary: This study found that certain blood-based biomarkers are associated with clinical risk of Alzheimer's disease in a long-term community cohort. A beta misfolding and GFAP concentration were particularly important and accurate predictors of AD risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Sean van Diepen, Wayne Tymchak, Erin A. Bohula, Jeong-Gun Park, Lori B. Daniels, Nicholas Phreaner, Christopher F. Barnett, Benjamin B. Kenigsberg, Andrew DeFilippis, Narayana Sarma Singam, Gregory W. Barsness, Jacob C. Jentzer, Bradley Ternus, David A. Morrow, Jason N. Katz
AMERICAN HEART JOURNAL
(2020)
Article
Medicine, General & Internal
Amit K. Pandey, Thao Duong, Iwona Swiatkiewicz, Lori B. Daniels
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Lori B. Daniels, Amy M. Sitapati, Jing Zhang, Jingjing Zou, Quan M. Bui, Junting Ren, Christopher A. Longhurst, Michael H. Criqui, Karen Messer
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Nicholas Phreaner, Lori B. Daniels
Article
Multidisciplinary Sciences
Lori B. Daniels, Junting Ren, Kris Kumar, Quan M. Bui, Jing Zhang, Xinlian Zhang, Mariem A. Sawan, Howard Eisen, Christopher A. Longhurst, Karen Messer
Summary: Research suggests that patients taking statins prior to hospitalization for COVID-19 have significantly lower odds of death, particularly among those with a history of cardiovascular disease and/or hypertension.
Article
Pathology
Nicholas J. Bevins, Hyojin Chae, Jacqueline A. Hubbard, Edward M. Castillo, Vaishal M. Tolia, Lori B. Daniels, Robert L. Fitzgerald
Summary: The implementation of high-sensitivity cardiac troponin T (hsTnT) algorithms can decrease the 30-day return rates and emergency department length of stay for patients with chest pain, despite incomplete adoption of the 0/1-hour algorithm.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ankeet S. Bhatt, David D. Berg, Erin A. Bohula, Carlos L. Alviar, Vivian M. Baird-Zars, Christopher F. Barnett, James A. Burke, Anthony P. Carnicelli, Sunit-Preet Chaudhry, Lori B. Daniels, James C. Fang, Christopher B. Fordyce, Daniel A. Gerber, Jianping Guo, Jacob C. Jentzer, Jason N. Katz, Norma Keller, Michael C. Kontos, Patrick R. Lawler, Venu Menon, Thomas S. Metkus, Jose Nativi-Nicolau, Nicholas Phreaner, Robert O. Roswell, Shashank S. Sinha, R. Jeffrey Snell, Michael A. Solomon, Sean Van Diepen, David A. Morrow
Summary: This study evaluated admissions to cardiac intensive care units for HF-CS in 28 centers and found that patients with de novo HF-CS, despite having fewer comorbidities, had more severe shock presentations and worse in-hospital outcomes.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Christian O'Donnell, Melanie D. Ashland, Elena C. Vasti, Ying Lu, Andrew Y. Chang, Paul Wang, Lori B. Daniels, James A. de Lemos, David A. Morrow, Fatima Rodriguez, Connor G. O'Brien
Summary: Elevated NT-proBNP levels on admission for COVID-19 are associated with an increased risk of in-hospital mortality and other complications in patients, demonstrating significant prognostic value.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Lori B. Daniels, Nicholas L. Mills, Christian Mueller
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Lori B. Daniels, Kris Kumar
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2022)
Article
Multidisciplinary Sciences
Ram M. Poudel, Lori Daniels, Andrew J. DeFilippis, Naomi Hamburg, Yosef C. Khan, Rachel Keith, Revanthy Sampath Kumar, Andrew Strokes, Rose Marie Robertson, Aruni Bhatnagar
Summary: This study investigated whether smokers hospitalized for COVID-19 are at a greater risk for developing severe complications than non-smokers. The study found that smokers had higher odds of death, the use of mechanical ventilation, and increased risk of major adverse cardiovascular events.
Article
Emergency Medicine
W. Frank Peacock, Alan S. Maisel, Christian Mueller, Stefan D. Anker, Fred S. Apple, Robert H. Christenson, Paul Collinson, Lori B. Daniels, Deborah B. Diercks, Salvatore Di Somma, Gerasimos Filippatos, Gary Headden, Brian Hiestand, Judd E. Hollander, Juan C. Kaski, Joshua M. Kosowsky, John T. Nagurney, Richard M. Nowak, Donald Schreiber, Gary M. Vilke, Marvin A. Wayne, Martin Than
Summary: This study aims to evaluate the utility of a highly sensitive troponin assay in the emergency department. It includes prospective data collection of early presenting patients, and diagnoses acute coronary syndrome through both clinical assessment and laboratory testing. Furthermore, the stability of different troponin assays is also assessed.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Siddharth M. Patel, David D. Berg, Erin A. Bohula, Vivian M. Baird-Zars, Christopher F. Barnett, Gregory W. Barsness, Sunit-Preet Chaudhry, Lori B. Daniels, Sean van Diepen, Shahab Ghafghazi, Michael J. Goldfarb, Jacob C. Jentzer, Jason N. Katz, Benjamin B. Kenigsberg, Patrick R. Lawler, P. Elliot Miller, Alexander I. Papolos, Jeong-Gun Park, Brian J. Potter, Rajnish Prasad, N. Sarma V. Singam, Shashank S. Sinha, Michael A. Solomon, Jeffrey J. Teuteberg, David A. Morrow
Summary: Algorithmic application of the 2019 SCAI shock stages effectively stratifies mortality risk for patients with cardiogenic shock, but clinician assessment of SCAI staging may differ. Moreover, the implications of the 2022 SCAI criteria update remain incompletely defined. Updated algorithmic staging using the 2022 SCAI criteria and vasoactive-inotropic score further refines risk stratification.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
David Agdashian, Lori B. Daniels
Summary: The role of cardiac troponin in prognosis, prediction, and response to therapy for heart failure is reviewed. Recent studies have shown that therapies such as neprilysin inhibitor sacubitril/valsartan and sodium-glucose cotransporter-2 inhibitors can improve outcomes in heart failure patients. Troponin has prognostic value across the heart failure spectrum, but its potential role in heart failure prevention, tailoring of treatments, and guiding interventions remains unknown.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Quan M. Bui, Kevin King, Anthony DeMaria, Lori B. Daniels
Summary: Patients with COVID-19 exhibit evidence of subclinical cardiac dysfunction with reduced GLS despite preserved LV function. These findings are consistent irrespective of prior history of CVD, presence of COVID-19 symptoms, or illness severity.
IJC HEART & VASCULATURE
(2021)