Journal
JOURNAL OF CARDIAC FAILURE
Volume 15, Issue 6, Pages 489-495Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2009.01.005
Keywords
Heart failure; population; diagnosis; echocardiography; ProBNP
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Funding
- Lundbeck Foundation
- Novo Nordisk Foundation
- Copenhagen County Research Foundation
- C.C. Klestrup Foundation
- Foundation Promoting Medicine
- Lykfeldt Foundation
- CM Sorensen and Wife's Foundation
- Danish Heart Foundation [07-10-R60-A1698-B132-22413]
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Background: Heart failure is a major public health problem. To improve grave prognosis. early identification of, Cardiac dysfunction is mandatory. Conventional echocardiography is not suitable for this. Tissue Doppler imaging (TDI). however, could be so. Methods and Results: Within a large community-based population-study (n = 1012), cardiac function was evaluated by conventional echocardiography (left ventricular hypertrophy, dilatation, systolic, and severe diastolic dysfunction), TDI, and plasma proBNP. Averages of peak systolic (s'), early diastolic (e'), and late diastolic(a') velocities from 6 mitral annular sites were used. TDI was furthermore quantified by a combined index (eas-index) of diastolic and systolic performance: e'/(a' x s'). Compared with controls, persons with elevated plasma proBNP concentrations (n = 100) displayed lower systolic and diastolic performance by TDI, in terms of lower s'(P = 0.017) and a' (P < .001), and higher e'/a' (P = .002) and eas-index (P < .001). This pattern remained significant after multivariable adjustment for age, sex, body mass index, heart rate, estimated glomerular filtration rate, hypertension, diabetes, ischemic heart disease, and conventional echocardiography. Furthermore, TDI provided incremental information over conventional echocardiography in predicting elevated plasma proBNP concentrations. Conclusions: Preclinical systolic and diastolic dysfunction by TDI is associated with elevated plasma proBNP levels, even when conventional echocardiography is normal. (J Cardiac Fail 2009;15;489-495)
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