Journal
JOURNAL OF CARBOHYDRATE CHEMISTRY
Volume 31, Issue 7, Pages 553-570Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2011.654017
Keywords
Mycobacterium tuberculosis; Cell wall biosynthesis; UDP-galactopyranose (UDP-Galp) mutase; UDP-Galp mimics; Antimycobacterial agents
Funding
- NIPER
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O-Galactopyranosides were synthesized as potential mimics of uridine 5c-diphosphate galactopyranose (UDP-Galp), which is the substrate of the mutase enzyme involved in the mycobacterial cell wall biosynthesis by converting UDP-Galp to UDP-Galf. In vitro assay against the Mycobacterium tuberculosis H37Rv strain gave promising results with minimum inhibitory concentration (MIC) values in the range of 3.13 to 25 mu g/mL.
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