Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma

Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma

(2012) Bo Hui et al.   CANCER

Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma

(2012) William C. Palmer et al.   JOURNAL OF HEPATOLOGY

PKC  Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4-ATF3/CHOP Axis in Human Lung Cancer Cells

(2012) L. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

(2012) Li Jia et al.   PLoS One

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

(2012) Daisuke Oikawa et al.   PLoS One

Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

(2012) S Kawabata et al.   Cell Death & Disease

Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini

(2012) Banchob Sripa et al.   PLoS Neglected Tropical Diseases

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

(2011) Tomasz Rzymski et al.   CELL CYCLE

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

Intra-hepatic cholangiocarcinoma—frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center

(2011) Ashwani K. Singal et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cholangiocarcinoma—controversies and challenges

(2011) Tushar Patel   Nature Reviews Gastroenterology & Hepatology

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany

(2011) Thomas von Hahn et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Proteasome inhibition: A new therapeutic strategy to cancer treatment

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-κB

(2010) Wunchana Seubwai et al.   CANCER SCIENCE

Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

(2010) Chunyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bortezomib induces canonical nuclear factor- B activation in multiple myeloma cells

(2009) T. Hideshima et al.   BLOOD

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preferential Cytotoxicity of Bortezomib toward Hypoxic Tumor Cells via Overactivation of Endoplasmic Reticulum Stress Pathways

(2008) D. R. Fels et al.   CANCER RESEARCH

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells

(2008) Seiji Okada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma

(2008) David T Yang et al.   Molecular Cancer

Bortezomib-Resistant Nuclear Factor- B Activity in Multiple Myeloma Cells

(2008) S. Markovina et al.   MOLECULAR CANCER RESEARCH

Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma

(2008) Jesús F. San Miguel et al.   NEW ENGLAND JOURNAL OF MEDICINE