Article
Immunology
Guangyu Liu, Yan Zhang, Sansheng Han, Wei Zhuang, Jie Lv, Mengyao Han, Ling Xie, Xiangrui Jiang, Chun Wang, Kaidireya Saimaier, Jingshan Shen, Changsheng Du
Summary: Autoimmune hepatitis (AIH) can lead to irreversible liver damage such as fibrosis, cirrhosis, and hepatocellular carcinoma. The study used a mouse model to investigate the effect of the artemisinin derivative TPN10466 on AIH. It was found that TPN10466 inhibited the production of IFN-gamma by T cells and reduced the severity of AIH by regulating lymphocyte function and number in the liver. The treatment also suppressed T-cell responses through the inhibition of JNK, ERK, and p38 pathways. These findings suggest that TPN10466 has potential as a therapeutic agent for AIH.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Koichi Nakamura, Kunihiro Asanuma, Takayuki Okamoto, Takahiro Iino, Tomohito Hagi, Tomoki Nakamura, Akihiro Sudo
Summary: The combination of everolimus and bortezomib has shown synergistic antiproliferative and apoptotic effects against fibrosarcoma and osteosarcoma, suppressing pulmonary metastases. Everolimus and bortezomib inhibit tumor growth via the JNK/p38/ERK MAPK and AKT pathways. This combination therapy shows promise as a new therapeutic strategy for bone and soft tissue sarcomas.
Article
Biochemistry & Molecular Biology
Zhangshuo Yang, Hao Zhang, Maohui Yin, Zhixiang Cheng, Ping Jiang, Maohui Feng, Bo Liao, Zhisu Liu
Summary: This study found that NTF3 is significantly downregulated in human hepatocellular carcinoma (HCC) and its low expression is associated with shorter survival and poor clinical outcomes. NTF3 inhibits the progression of HCC cells by activating the p75NTR and JNK/P38 MAPK pathways to induce apoptosis. Therefore, NTF3 may serve as a potential treatment molecule for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Jae Hwa Seo, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Ah-Reum Cho, Jinsuk Koo, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim
Summary: In this study, the anti-epithelial-mesenchymal transition (EMT) and antifibrotic effects of Honokiol in liver fibrosis were explored. It was found that Honokiol can suppress TGF-beta 1-induced EMT and migration of liver cells and inhibit hepatic fibrosis by regulating the E-cadherin/GSK3 beta/JNK pathway and inhibiting the AKT/ERK/p38/beta-catenin/TMPRSS4 signaling axis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ben Ye, Jianhua Ma, Zhaoxia Li, Yang Li, Xiaopan Han
Summary: The study demonstrated that ononin has remarkable antitumor activity against laryngeal cancer Hep-2 cells. Treatment with ononin effectively inhibited cell viability, induced apoptosis, and improved intracellular ROS accumulation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Walaa Yehia Abdelzaher, Seham A. Abdel-Gaber, Michael Atef Fawzy, Abdel Hamid Sayed Abo Bakr Ali, Mina Ezzat Attya, Ayman Geddawy
Summary: Atorvastatin may protect against cyclophosphamide-induced thyroid injury by regulating the JNK/ERK/p38-MAPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Respiratory System
Mingzhou Guo, Mengzhe Zhang, Xiaopei Cao, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Jianping Zhao, Yongjian Xu, Xiansheng Liu, Xiaochen Li
Summary: This study reveals the important role of the Notch4-ERK/JNK/P38 MAPK axis in hypoxic pulmonary remodeling. Increased expression of Notch4 promotes proliferation and migration of HPASMCs and inhibits apoptosis through the ERK, JNK, and P38 signaling pathways. Silencing Notch4 partially alleviates the increase in RVSP and pulmonary vascular remodeling caused by hypoxia. These findings provide a potential therapeutic target for patients with HPH.
RESPIRATORY RESEARCH
(2022)
Article
Environmental Sciences
Zhiruo Miao, Zhiying Miao, Xu Shi, Hao Wu, Yujie Yao, Shiwen Xu
Summary: Lead and selenium interact in chicken kidneys, and selenium can regulate the signaling pathway activated by lead, reducing the damage to chicken kidney cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biotechnology & Applied Microbiology
Thuy Phan, Xu Hannah Zhang, Steven Rosen, Laleh G. Melstrom
Summary: Gastrointestinal cancers are a major cause of cancer-related morbidity and mortality worldwide. The p38 signaling pathway, particularly p38 gamma, plays a crucial role in cancer development and metastasis. This article provides an overview of p38 and p38 gamma in gastrointestinal cancers, as well as discusses the potential of targeting p38 gamma as a therapy.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yu Yang, Ruonan Li, Junnan Hui, Lingqian Li, Xin Zheng
Summary: The study demonstrates that beta-carotene can alleviate rat intestinal inflammation by modulating autophagy and regulating JAK2/STAT3 and JNK/p38 MAPK signaling pathways. This effect was verified in intestinal epithelial cell (IEC)-6, providing new insights into improving nutritional value of basic diets and enhancing immune performance. Beta-carotene shows anti-inflammatory potential and can be beneficial against LPS-induced inflammation damage, laying foundation for related research in vitro and in rat models.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Sirorat Janta, Kanta Pranweerapaiboon, Pornpun Vivithanaporn, Anuchit Plubrukarn, Arthit Chairoungdua, Prachayaporn Prasertsuksri, Somjai Apisawetakan, Kulathida Chaithirayanon
Summary: This study revealed the role of RUNX1 in promoting EMT-driven metastasis of prostate cancer and found that HA can inhibit the EMT and metastatic processes, potentially serving as a candidate for metastatic PCa treatment.
Article
Food Science & Technology
Yinghao Liao, Yali Deng, Xiaojin Yu, Peng Zhang, Ran Liu
Summary: This study reveals the regulatory relationship between MC-LR and GC progression, providing new avenues for conducting in vitro toxicity tests based on the investigated pathways. It highlights the pivotal roles of AKT, ERK, and JNK signaling in MC-LR toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Walaa Yehia Abdelzaher, Haitham Ahmed Bahaa, Reham Elkhateeb, Medhat Atta, Michael Atef Fawzy, Amira F. Ahmed, Remon Roshdy Rofaeil
Summary: This study aimed to evaluate the effect of the phosphodiesterase 5 inhibitor, sildenafil (Sild), on cyclophosphamide (CYC)-induced placental injury in rats. The results showed that Sild significantly improved the oxidative stress, inflammation, and apoptosis caused by CYC.
Article
Automation & Control Systems
Lina Rong, Guo-Ping Jiang, Shengyuan Xu
Summary: This article focuses on the design of distributed nonrecursive averaging filters for the quantized consensus problem of discrete-time first-order multiagent systems over undirected and connected networks. The quantized consensus problem is transformed into a robust consensus problem with sector bound uncertainties associated with communication graphs. Necessary and sufficient conditions for filter parameter preservation of robust consensus with sector bound uncertainties are provided. The optimal filter parameter design is achieved through constrained optimization, ensuring robust consensus with maximal sector bound parameter.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Article
Automation & Control Systems
Jing Zhao, Xiaoqian Ding, Bin Jiang, Guoping Jiang, Fei Xie
Summary: This article investigates a fault-tolerant control method for quadrotors with variable mass and actuator faults. A mathematical model is established and an adaptive estimation algorithm is designed to estimate the variable mass and actuator fault. Control strategies are then developed based on these estimations to achieve trajectory tracking and attitude control.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Automation & Control Systems
Lina Rong, Peng Su, Guo-Ping Jiang, Shengyuan Xu
Summary: In this paper, an edge-based augmented system approach is proposed for second-order nodal consensus, utilizing the edge loop transfer matrix of the closed-loop multi-agent system. This approach introduces additional poles and zeros into edges to construct a channel filter with previous data stored in the memories. The effectiveness of the proposed method is verified through illustrative simulations.
Article
Engineering, Electrical & Electronic
Lina Rong, Yuhan Kan, Xiangpeng Xie, Guo-Ping Jiang, Shengyuan Xu
Summary: This study focuses on the problem of edge-preserving consensus in discrete-time multi-agent systems. A method for designing channel filters, consisting of nominal elements and masking elements, is proposed using an edge-based parallel system design approach. Design criteria for edge-preserving protocols are provided based on the edge sensitivity matrix of the multi-agent system being studied. It is demonstrated that the design of masking elements is based on a single parameter of the nominal element and the H-infinity norm of a collapsed system. An algorithm for designing heterogeneous channel filters is also presented, using a cascade realization of several subsystems.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Engineering, Electrical & Electronic
Huifen Hong, Wenwu Yu, Guo-Ping Jiang, He Wang
Summary: In this paper, a novel type of fixed-time algorithms is investigated to solve time-varying convex optimization problems with time-dependent cost function, constraints or both. First, a general framework algorithm is developed for the unconstrained time-varying optimization problem to track its optimal trajectory within fixed time, which includes the gradient flow-based scheme and Newton-type method as special cases. Then, another algorithm with fixed-time convergence is designed for time-varying optimization problems involving equality constraint, including Newton-type scheme as a special case. The simulation result using first-order Euler discretization is provided to verify the fixed-time convergence achieved by the proposed approach.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Automation & Control Systems
Yayong Wu, Xinwei Wang, Guo-Ping Jiang, Mengqi Gu
Summary: In this paper, a completely data-driven method based on compressive sensing is proposed to detect the structure of faulty edges in complex dynamical networks. The method can directly obtain the structure of faulty edges from limited measurements and is more efficient in data processing.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Physics, Multidisciplinary
Ruqi Li, Yurong Song, Haiyan Wang, Guo-Ping Jiang, Min Xiao
Summary: This study develops a reactive-diffusion epidemic model on human mobility networks to characterize the spatio-temporal propagation of COVID-19 in China. A novel time-dependent function is incorporated to describe the effects of human intervention. The results indicate that human intervention significantly inhibits the correlation between population mobility and infection cases, and spatial diffusion phenomenon of cases from high infection density cities to low infection density cities is revealed.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Automation & Control Systems
Binbin Tao, Min Xiao, Wei Xing Zheng, Ying Zhou, Jie Ding, Guoping Jiang, Xiaoqun Wu
Summary: This article proposes a time-delay feedback control strategy with distributed characteristics to address the flaws in existing control strategies. The designed controller ensures the invariance of equilibriums and continuity of stability intervals, effectively improving the bifurcation threshold of the controlled object.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Article
Automation & Control Systems
Zhikai Yao, Xianglong Liang, Guo-Ping Jiang, Jianyong Yao
Summary: This article introduces a new model-based reinforcement learning controller to improve the control performance of hydraulic systems. By using a recursive robust integral control approach and an actor-critic structure in the reinforcement learning approach, the proposed controller is able to achieve high-accuracy tracking and asymptotic stability guarantees at the system level.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Mathematics, Interdisciplinary Applications
Y. Wang, H. Yang, X. Y. Yan, G. P. Jiang
Summary: In this paper, a novel coupled code shifted M-ary differential chaos shift keying modulation scheme is proposed for reference removal. The scheme transmits only two information-bearing signals, modulated by selected Walsh code sequences and coupled by the same chaotic message bearer. Theoretical BER expressions are derived and simulations show better performance with lower complexity.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Green & Sustainable Science & Technology
Chaoyue Zheng, Guoping Jiang, Zhiliang Jin
Summary: This paper studies the doping of phosphorus elements in Co3(PO4)2 during the high-temperature phosphorylation reaction. UV-Vis experiments show that the color of the phosphorylation catalyst changes from pink to black-purple, with significantly increased light absorption range and intensity. SEM images reveal the growth of many nanoparticles on the catalyst surface. XPS experiments demonstrate the growth of a stable P (6- )-Co bond on the catalyst surface. The P (6- )-Co bond can inhibit the complexation of photogenerated electron and hole pairs and enhance the transport efficiency of photogenerated electrons, thus improving the hydrogen production performance. Phosphorus-doped Co3(PO4)2 releases three times more hydrogen than CO3(PO4)2. This paper provides a novel design solution for the photocatalyst preparation method.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Geological
Yan Wang, Hao-biao Chen, Guo-ping Jiang, Fu-quan Chen
Summary: In this research, a slip-line method and adaptive finite-element software were used to investigate the active earth pressure of narrow and layered backfills against inverted T-type retaining walls rotating around the base mode. Slip-line field calculation models were established for the inverted T-type retaining wall with narrow and layered backfills, considering the effect of the heel bottom plate and the wall characteristics. The proposed method was verified by comparing its results with those from finite-element limit analysis and existing theoretical solutions, and parametric studies were conducted to study the effects of backfill width, heel length, and interface strength.
INTERNATIONAL JOURNAL OF GEOMECHANICS
(2023)
Article
Mathematics
Mengqi Gu, Guo-Ping Jiang
Summary: This paper investigates the observability of discrete-time two-time-scale multi-agent systems with heterogeneous features under leader-follower architecture. It establishes a singular perturbation difference model for the discussed system based on consensus agreement. To eliminate the numerical ill-posed problem, the order of the system model is reduced using the boundary layer theory of the singular perturbation system. Based on matrix theory, algebraic and graphical features that guarantee system observability are obtained. The theoretical results are verified by a numerical example.
Article
Biochemistry & Molecular Biology
Wenjiao Jin, Junming Yu, Yang Su, Hechun Lin, Tengfei Liu, Jing Chen, Chao Ge, Fangyu Zhao, Qin Geng, Lin Mao, Shuqing Jiang, Ying Cui, Taoyang Chen, Guoping Jiang, Jinjun Li, Chunxiao Miao, Xiuying Xiao, Hong Li
Summary: Hepatocellular carcinoma (HCC) is a highly lethal cancer, lacking effective therapies especially for advanced-stage patients. By screening the US FDA drug library, flubendazole, a traditional anthelmintic drug, was identified to significantly suppress HCC cells in vivo and in vitro. Flubendazole reduced PCSK9 expression by directly targeting it, which was found to be increased in HCC tissues and correlated with poor prognosis. The inhibitory effect of flubendazole on HCC relied on PCSK9 expression and was mediated via the Hedgehog signaling pathway. Combining flubendazole with lenvatinib exhibited enhanced efficacy for HCC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Proceedings Paper
Automation & Control Systems
Manru Cheng, Guo-Ping Jiang, Yurong Song, Chen Yang
Summary: This paper proposes a multi fusion graph network dynamic spatiotemporal traffic flow prediction model based on graph attention, which comprehensively considers various road structure information to construct a traffic graph network and captures the dynamic transformation of traffic flow data through graph attention, thereby improving the accuracy of traffic flow prediction.
2022 41ST CHINESE CONTROL CONFERENCE (CCC)
(2022)
