Article
Biochemistry & Molecular Biology
Lars Schroeder, Christian M. Domroese, Alexander B. A. Rupp, Kathrin M. E. Gihr, Christoph Niederau, Michael R. Mallmann, Stefan Holdenrieder
Summary: This study found that CA-125 and TPA showed promising results as screening tools for ovarian or uterine cancer. Both biomarkers were able to discriminate between malignant and non-malignant cases in the overall sample. However, TPA was the best diagnostic marker for uterine cancer, while CA-125 was the best for ovarian cancer.
Article
Medicine, General & Internal
Phichayut Phinyo, Jayanton Patumanond, Panprapha Saenrungmuaeng, Watcharin Chirdchim, Tanyong Pipanmekaporn, Apichat Tantraworasin, Theera Tongsong, Charuwan Tantipalakorn
Summary: The study demonstrated that the model combining IOTA Simple Rules and serum CA-125 information was significantly superior in predicting the malignant potential of ovarian tumors compared to using only IOTA Simple Rules. This model, known as the IOTA SR X CA-125 model, showed high discriminative ability and could potentially aid in guiding patient referrals to oncologic specialists.
Article
Pathology
Manoj K. Bind, Ravi R. Mishra, Varsha Kumar, Vatsala Misra, Premala A. Singh
Summary: The study aimed to assess serum CA19-9 and CA 125 in patients with gall bladder lesions and determine a cut off value for the diagnosis of gall bladder carcinoma. Results showed that both CA19-9 and CA 125 have high sensitivity and specificity in detecting malignant cases, serving as good adjuncts for diagnosing gall bladder carcinoma.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2021)
Article
Health Care Sciences & Services
Oana Balint, Cristina Secosan, Laurentiu Pirtea
Summary: This study found a positive correlation between CA-125 levels and the severity of hypertensive disorders of pregnancy. CA-125 can be used as a marker to evaluate the severity and manage high-risk patients. Further research is needed to improve the accuracy of the results and determine the optimal measurement time.
Article
Medicine, General & Internal
Seval Ay, Deniz Tataroglu Ozyukseler, Ozgecan Dulgar, Mustafa Basak, Mahmut Emre Yildirim, Mahmut Gumus
Summary: An observational study was conducted to investigate the relationship between the cut-off level of cancer antigen 125 (CA 125) and long-term prognosis in high-grade serous ovarian cancer (HGSCs). The results showed that initial CA 125 levels could predict disease-free and overall survival rates, with significant differences observed especially in stage III disease. This suggests that CA 125 level may have beneficial clinical predictive value for HGSC.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Oncology
Mengmeng Li, Ruyue Xing, Jiuyan Huang, Chao Shi, Chunhua Wei, Huijuan Wang
Summary: Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive variant of inflammatory myofibroblastic tumor (IMT) with poor prognosis. EIMS is characterized by epithelioid morphology, neutrophilic infiltrate, and specific fusion partners of anaplastic lymphoma kinase (ALK). ALK tyrosine kinase inhibitors (TKIs) are recommended as therapy for EIMS, although there is no standard treatment. This study presented a case of successful targeted therapy with ensartinib in a patient with recurrence and multiple metastases, showing sustained partial response and no recurrence for 4 months.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jason R. Pettus, Darcy A. Kerr, Radu V. Stan, Julie Y. Tse, Einar F. Sverrisson, Julia A. Bridge, Konstantinos Linos
Summary: The study describes a rare mesenchymal tumor in the kidney with a novel GLI1-FOXO4 fusion gene. The clinical and morphologic features of this tumor appear distinct from other neoplasms harboring GLI1 or FOXO4 gene rearrangements, warranting long-term follow-up.
GENES CHROMOSOMES & CANCER
(2021)
Article
Pathology
Inigo Espinosa, Emanuela D'Angelo, Louise De Brot, Jaime Prat
Summary: A study revealed that most extrarenal rhabdoid tumors of the vulva are proximal-type epithelioid sarcomas. By analyzing the clinicopathologic, immunohistochemical, and molecular features of these tumors, it was found that they have distinct expressions.
Article
Oncology
Er Yue, Guangchao Yang, Yuanfei Yao, Guangyu Wang, Atish Mohanty, Fang Fan, Ling Zhao, Yanqiao Zhang, Tamara Mirzapoiazova, Tonya C. Walser, Lorna Rodriguez-Rodriguez, Yuman Fong, Ravi Salgia, Edward Wenge Wang
Summary: Ovarian cancer is a deadly disease with urgent need for new treatments. The development of a conditionally replicative oncolytic adenovirus (CRAd) that targets MUC16/CA-125 in cancer cells shows promising anti-cancer effects. This approach represents a unique and practical direction for further investigation in ovarian cancer treatment.
Review
Chemistry, Analytical
Mehrab Pourmadadi, Ali Moammeri, Amin Shamsabadipour, Yasamin Farahanian Moghaddam, Abbas Rahdar, Sadanand Pandey
Summary: Diagnosing early-stage cancers is crucial for saving lives and reducing mortality rates. Detection of the cancer antigen CA-125 is a key step in the treatment of certain cancers, such as ovarian cancer. This review discusses various optical and electrochemical methods for detecting CA-125, compares their performance and sensitivity, investigates commercial detection kits, and evaluates their applicability and accuracy.
Article
Gastroenterology & Hepatology
Seema Rani Sinha, Prem Prakash, Rakesh Kumar Singh, Dinesh Kumar Sinha
Summary: This study found that tumor markers including CA 19-9, CA 125, CEA, and CA 242 were significantly elevated in patients with GBC. However, no significant association was observed between the presence of elevated levels of any tumor marker with respect to survival.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Cell Biology
Elisa Del Savio, Roberta Maestro
Summary: This review summarizes the pathobiology of epithelioid sarcoma, including defects in chromatin remodeling and other signaling pathways, and their role as therapeutic vulnerabilities.
Article
Oncology
Samuel Rasmussen, Jia Xiang Jin, Lissett R. Bickford, Andrew D. Woods, Felix Sahm, Kenneth A. Crawford, Kiyo Nagamori, Hiroaki Goto, Keila E. Torres, Angelo Sidoni, Erin R. Rudzinski, Khin Thway, Robin L. Jones, Alessio Ciulli, Hollis Wright, Melvin Lathara, Ganapati Srinivasa, Kavya Kannan, Paul H. Huang, Thomas G. P. Grunewald, Noah E. Berlow, Charles Keller
Summary: This study used a functional genomics approach to identify key signaling pathway vulnerabilities in EPS patient samples, revealing subtle differences between distal, pediatric/young adult-associated EPS and proximal, adult-associated EPS. These differences highlight the need to approach the two subtypes as molecularly and clinically distinct diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Anne Catherine Harttrampf, Maria Eugenia Marques da Costa, Aline Renoult, Estelle Daudigeos-Dubus, Birgit Geoerger
Summary: Epithelioid sarcomas and rhabdoid tumors, both characterized by INI1 alterations, were found to exhibit significant sensitivity to the pan-HDAC inhibitor panobinostat, which led to potent anti-proliferative activity, induction of apoptosis, and regulation of growth factor receptors. This study suggests that HDAC inhibitors may have therapeutic relevance in combination with therapeutics targeting cellular salvage mechanisms for improved anticancer effects.
Article
Medicine, Research & Experimental
Jingwen Wang, Chen Lu, Xi Tang
Summary: This study reports a case of epithelioid sarcoma (ES) in the adrenal gland, which was identified and analyzed using immunohistochemistry and next-generation sequencing technology. Partial remission was achieved through the application of immune checkpoint inhibitors (ICI).
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)