Article
Neurosciences
Venkateswarlu Gonuguntla, Ehwa Yang, Yi Guan, Bang-Bon Koo, Jae-Hun Kim
Summary: This study proposes a framework for constructing a brain network using sMRI data and successfully extracts brain signature patterns and critical regions associated with cognitive impairment and Alzheimer's disease. The results demonstrate the potential applications of this framework in brain mapping and brain network-based applications.
HUMAN BRAIN MAPPING
(2022)
Article
Geriatrics & Gerontology
Xi Wang, Qianhua Zhao, Rui Tao, Huimeng Lu, Zhenxu Xiao, Li Zheng, Ding Ding, Saineng Ding, Yichen Ma, Zhaozeng Lu, Yiqin Xiao
Summary: The study found that the superficial vascular density in AD and MCI patients was significantly lower than in the healthy control group. This suggests that retinal microvascular dysfunction may occur early in MCI and AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Alar Kaskikallio, Mira Karrasch, Juha Koikkalainen, Jyrki Lotjonen, Juha O. Rinne, Terhi Tuokkola, Riitta Parkkola, Petra Gronholm-Nyman
Summary: This study examined the relationship between WMH and verbal fluency in healthy elderly individuals and those with MCI/AD, finding associations between WMH in certain brain areas and impaired semantic fluency, particularly in right-handed participants. Elevated levels of WMH were not found to have cumulative effects on verbal fluency impairment in patients with MCI or AD, suggesting further research is needed in this area.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Florinda Ferreri, Andrea Guerra, Luca Vollero, David Ponzo, Sara Maeaetta, Mervi Koenoenen, Fabrizio Vecchio, Patrizio Pasqualetti, Francesca Miraglia, Ilaria Simonelli, Maurizio Corbetta, Paolo Maria Rossini
Summary: The study revealed reduced excitability in the sensorimotor cortex and disrupted EEG synchronization in aMCI patients, with alterations in intertrial coherence in different frequency bands serving as potential predictors of cognitive status in aMCI. Importantly, differences in beta and gamma coherence were observed between those who clinically converted to AD and those who remained cognitively stable, suggesting these changes may serve as neurophysiological biomarkers for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Health Care Sciences & Services
Carolina Lopez, Miren Altuna
Summary: Population aging increases the risk of neurodegenerative diseases and cognitive impairment. Early diagnosis and social awareness have led to an increase in the number of diagnosed individuals, but also pose new challenges. Understanding the psychosocial impact of diagnosis and developing strategies to address them are crucial.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Neurosciences
Delshad Vaghari, Ehsanollah Kabir, Richard N. Henson
Summary: This study examined the potential of Magnetoencephalography (MEG) in early detection of Alzheimer's disease (AD). The results showed that combining MEG data with structural MRI data improved classification accuracy for Mild Cognitive Impairment (MCI) patients. However, MEG alone performed worse than MRI alone. Other MEG features were found to provide complementary information for classification above MRI.
Article
Health Care Sciences & Services
Cheng-Li Liu, Che-Jen Chuang, Chin-Mei Chou
Summary: Mild cognitive impairment (MCI) refers to the decline in brain function between normal aging and the AD stage. This study developed a MCI assessment system using 3D virtual reality and fuzzy logic control technology, which showed a high correlation with traditional screening tests. The assessment system received positive feedback and provided an integrated reference score for clinic workers.
Article
Chemistry, Analytical
Fatma El-Zahraa A. El-Gamal, Mohammed Elmogy, Ali Mahmoud, Ahmed Shalaby, Andrew E. Switala, Mohammed Ghazal, Hassan Soliman, Ahmed Atwan, Norah Saleh Alghamdi, Gregory Neal Barnes, Ayman El-Baz
Summary: This study investigated patients with mild cognitive impairment (MCI) using a local/regional-based computer-aided diagnosis system, which allowed visualization of the impact of Alzheimer's disease on cerebral cortical regions. The experimental results showed promising performance, with a maximum accuracy of 86.30%, specificity of 88.33%, and sensitivity of 84.88%. The system identified brain regions involved in language, executive function/cognition, and memory in MCI subjects, which are also implicated in the neuropathology of AD.
Article
Neurosciences
Hai-Tao Li, Shao-Xun Yuan, Jian-Sheng Wu, Yu Gu, Xiao Sun
Summary: This study introduces a subtype-based prediction strategy to predict the progression from MCI to AD in three years, using a variational Bayes approximation model based on multiple kernel learning method. Internal and external validations confirmed the improved accuracy in predicting conversion from MCI to AD by identifying MCI patient subtypes with omics data.
Article
Clinical Neurology
Federico Verde, Edoardo Nicolo Aiello, Ilaria Milone, Eleonora Giacopuzzi Grigoli, Antonella Dubini, Antonia Ratti, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani
Summary: This study compared the distribution of T +/- profiles among A+patients with MCI and dementia. The results showed that A+T+ profiles were predominant in both groups, contradicting the common notion of A+T- profiles being more prevalent in MCI patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Bin Jiao, Rihui Li, Hui Zhou, Kunqiang Qing, Hui Liu, Hefu Pan, Yanqin Lei, Wenjin Fu, Xiaoan Wang, Xuewen Xiao, Xixi Liu, Qijie Yang, Xinxin Liao, Yafang Zhou, Liangjuan Fang, Yanbin Dong, Yuanhao Yang, Haiyan Jiang, Sha Huang, Lu Shen
Summary: This study aimed to identify effective EEG biomarkers for distinguishing early-stage AD patients and monitoring disease progression. The results showed that EEG biomarkers can be used for the diagnosis and evaluation of MCI and AD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Una Smailovic, Daniel Ferreira, Birgitta Ausen, Nicholas James Ashton, Thomas Koenig, Henrik Zetterberg, Kaj Blennow, Vesna Jelic
Summary: Mild cognitive impairment (MCI) is highly prevalent in memory clinics and is heterogeneous regarding its clinical presentation, underlying pathophysiology, and prognosis. Synaptic loss and dysfunction are important factors in AD-related cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: This study longitudinally monitored plasma GSH levels and cognitive function in MCI patients, showing a significant decline over a 2-year period, while these levels remained relatively stable in healthy individuals. Both baseline GSH levels and changes in GSH levels were found to significantly influence cognitive decline in MCI patients, suggesting that blood GSH concentration may be a potential biomarker for monitoring cognitive changes in MCI.
Article
Computer Science, Artificial Intelligence
Ruhul Amin Hazarika, Arnab Kumar Maji, Samarendra Nath Sur, Iustin Olariu, Debdatta Kandar
Summary: Grey matter in the human brain contains important cells involved in neurophysiological operations. Alzheimer's disease is a neurological disease that kills brain cells in these regions. Mild Cognitive Impairment is a stage between normal cognition and Alzheimer's disease, characterized by significant cognitive decline. Evaluating changes in grey matter can help study overall brain transformations and accurately classify different stages of Alzheimer's disease.
JOURNAL OF INTELLIGENT & FUZZY SYSTEMS
(2022)
Article
Geriatrics & Gerontology
Lixiao Hao, Jianguo Jia, Yue Xing, Ying Han
Summary: SCD-Q9 has shown certain discrimination power in distinguishing between MCI and HC groups. When combined with age and education level, its performance slightly improves. Therefore, SCD-Q9 can be used as a brief screening tool for early detection of SCD in MCI, but further validation studies are needed to enhance its sensitivity.
AGING & MENTAL HEALTH
(2022)
Article
Neurosciences
Elizabeth Haddad, Fabrizio Pizzagalli, Alyssa H. Zhu, Ravi R. Bhatt, Tasfiya Islam, Iyad Ba Gari, Daniel Dixon, Sophia I. Thomopoulos, Paul M. Thompson, Neda Jahanshad
Summary: Automatic neuroimaging processing tools provide convenient and systematic methods for extracting features from brain magnetic resonance imaging scans. In this study, the reliability and compatibility of regional morphometric metrics derived from different versions of FreeSurfer were empirically assessed using test-retest data. The results showed lower compatibility between the latest version and older versions in terms of cortical thickness, surface area, and subcortical volumes. Replication studies in an independent sample confirmed these findings. The study highlights the importance of considering version-related inconsistencies in published findings.
HUMAN BRAIN MAPPING
(2023)
Article
Computer Science, Artificial Intelligence
Haoteng Tang, Lei Guo, Xiyao Fu, Yalin Wang, Scott Mackin, Olusola Ajilore, Alex D. Leow, Paul M. Thompson, Heng Huang, Liang Zhan
Summary: MRI-derived brain networks are widely used to understand interactions among brain regions and their relationships with brain development and diseases. Graph mining on these networks can help discover biomarkers for clinical phenotypes and neurodegenerative diseases. Most current studies focus on projecting structural networks onto functional networks to extract a fused representation.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Clinical Neurology
Maria P. Mogavero, Alessandro Silvani, Giuseppe Lanza, Lourdes M. DelRosso, Luigi Ferini-Strambi, Raffaele Ferri
Summary: After describing orexins and their roles in sleep and medical disorders, the article discusses the clinical evidence on the effects of DORAs and SORAs on insomnia to provide recommendations for further assessment in personalized and precision medicine. Trials with orexin receptor antagonists have shown potential as a valid therapeutic option for insomnia in various medical conditions, but more studies are needed to determine the most suitable options for different patient populations.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Biochemistry & Molecular Biology
Gianvito Caggiano, Loredana Amodio, Alessandra Stasi, Nicola Antonio Colabufo, Santina Colangiulo, Francesco Pesce, Loreto Gesualdo
Summary: In recent years, indoxyl sulfate has been found to play a significant role in the progression of kidney disease and the development of cardiovascular problems. However, current methods for measuring indoxyl sulfate levels, such as LC-MS/MS, are time-consuming and require specialized equipment. In this pilot study, we developed a fast and simple alternative method using colorimetric assay to accurately measure indoxyl sulfate levels in serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fabio Sallustio, Angela Picerno, Francesca Montenegro, Maria Teresa Cimmarusti, Vincenzo Di Leo, Loreto Gesualdo
Summary: The human virome, consisting of prokaryotes, viruses, fungi, and parasites, is intricately connected with the human host. Different viral community states have been identified as indicators of health or undesirable outcomes for the host. The virome can collaborate with the human host in maintaining mutualistic functions and preserving human health. This Review explores the role of viruses in health and disease, the relationship between the virobiota and immune system control, and the potential molecular mechanisms linking viruses to glomerulonephritis and IgA nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Raffaele Ferri, Maria P. Mogavero, Oliviero Bruni, Daniel L. Picchietti, Lourdes M. DelRosso
Summary: This study reviewed and selected studies on the evaluation of the effect of antidepressants on PLMS index during sleep. A meta-analysis using a random-effects model was conducted, and the level of evidence for each paper was assessed. Twelve studies were included in the analysis, seven interventional and five observational. The use of SSRIs showed a larger effect size compared to other antidepressants. However, more studies are needed to confirm the absent or smaller effect of other categories of antidepressants.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Chemistry, Analytical
Simonetta Panerai, Valentina Catania, Francesco Rundo, Domenica Tasca, Sabrina Musso, Claudio Babiloni, Giuseppina Prestianni, Stefano Muratore, Raffaele Ferri
Summary: Virtual reality (VR) has shown to be an effective tool for cognitive, motor, and daily activity rehabilitation in patients with major neurocognitive disorder (M-NCD). This study aimed to compare M-NCD caused by degenerative and non-degenerative conditions and assess the transfer from virtual to real environment in a non-immersive VR training (VRT). Four functional living skills (FLSs) were relearned using custom-made VR apps. The results showed significant improvements in both degenerative and non-degenerative M-NCD patients, indicating the ecological validity of VRT.
Editorial Material
Clinical Neurology
Federica Provini, Raffaele Ferri
Article
Clinical Neurology
Abubaker Ibrahim, Raffaele Ferri, Matteo Cesari, Birgit Frauscher, Anna Heidbreder, Melanie Bergmann, Birgit Hoegl, Ambra Stefani
Summary: This study investigated the frequency and characteristics of large muscle group movements (LMMs) during sleep in healthy adults. The results showed that LMMs are associated with other events and may have potential clinical significance.
Article
Virology
Davide Fiore Bavaro, Lucia Diella, Alessandra Belati, Giuliana Metrangolo, Laura De Santis, Vito Spada, Michele Camporeale, Angelo Dargenio, Gaetano Brindicci, Flavia Balena, Deborah Fiordelisi, Fabio Signorile, Giacomo Loseto, Crescenza Pasciolla, Carla Minoia, Immacolata Attolico, Tommasina Perrone, Simona Simone, Maria Rendina, Nicoletta Giovine, Francesco Di Gennaro, Pellegrino Musto, Attilio Guarini, Alfredo Di Leo, Loreto Gesualdo, Maria Dell'Aera, Annalisa Saracino
Summary: Remdesivir (REM) and monoclonal antibodies (mAbs) may alleviate severe COVID-19 in at-risk hospitalized patients, particularly in elderly or immunocompromised hosts. The use of REM and mAbs was associated with a reduced risk of severe COVID-19, and the combination therapy was particularly beneficial for immunocompromised patients.
Article
Biochemistry & Molecular Biology
Vincenzo G. Nicoletti, Francesco Fisicaro, Eugenio Aguglia, Rita Bella, Damiano Calcagno, Mariagiovanna Cantone, Carmen Concerto, Raffaele Ferri, Ludovico Mineo, Giovanni Pennisi, Riccardo Ricceri, Alessandro Rodolico, Giulia Saitta, Giulia Torrisi, Giuseppe Lanza, Manuela Pennisi
Summary: This study investigated the efficacy of repetitive transcranial magnetic stimulation (rTMS) on geriatric depression (GD). The results showed that high-frequency rTMS did not have a significant impact on mood, cognition, neurotrophic factors, cerebral blood flow, and cortical microcircuits. Underlying cerebrovascular disease and exposure to multiple pharmacological treatments may have contributed to the lack of improvement.
Article
Clinical Neurology
Antonio I. Triggiani, Kaya Scheman, Sarah Pirio Richardson, Masao Matsuhashi, Elizabeth Peckham, Fatta Nahab, Zoltan Mari, Shashi Ravindran, Mark Hallett
Summary: The objective of this study was to investigate the differences in subjective phenomenon and neural mechanisms between tics and voluntary movements in patients with tic disorders. Electroencephalographic and electromyographic data were recorded while subjects completed a Libet clock paradigm. The results showed that there were no significant differences in the timing and early potential activity between voluntary movements and tics in patients, suggesting that the sense of volition for tics is similar to that of voluntary movements.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Kerem Kemik, Emel Ada, Berrin Cavusoglu, Cansu Aykac, Derya Durusu Emek-Savas, Gorsev Yener
Summary: This study investigated neural activity changes in patients with Amnestic mild cognitive impairment (aMCI) using functional magnetic resonance imaging (fMRI). The results showed alterations in the visual network in resting-state and task-based fMRI, indicating that these changes may serve as early biomarkers for aMCI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Education & Educational Research
Francesco Domenico Di Blasi, Angela Antonia Costanzo, Maria Finocchiaro, Maria Agatina Stimoli, Rosa Zuccarello, Serafino Buono, Raffaele Ferri, Pierluigi Zoccolotti
Summary: A substantial proportion of children with autism spectrum disorder (ASD) also have an intellectual disability (ID). The academic achievement levels of students with ASD and ID (ASD-ID) are poorly documented and known. This systematic review examined the school skills of reading, spelling, and math in children and adolescents with ASD-ID. The results showed that students with ASD-ID had significantly lower scores in reading, spelling, and math compared to students with ASD without ID. Further research is needed to better understand the academic abilities of students with ASD-ID.
EDUCATION SCIENCES
(2023)
Article
Clinical Neurology
Claudio Babiloni, Claudio Del Percio, Claudia Piervincenzi, Filippo Carducci, Raffaele Ferri, Paolo Onorati, Ginevra Toma, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Antonio Aceti, Marco Salvatore, Andrea Soricelli, Elisabetta Teti, Alfredo Pennica, Loredana Sarmati, Vincenzo Vullo, Gabriella D'Ettorre, Claudio Mastroianni, Nikolaos Petsas, Patrizia Pantano, Roberto Floris, Fabrizio Stocchi, Massimo Andreoni, Giovanni Di Perri, Andrea Calcagno, Giuseppe Noce
Summary: The abnormal connectivity of parietal resting-state electroencephalographic (rsEEG) alpha waves is associated with subcortical white matter vascular lesions in HIV-positive individuals, even without neurocognitive disorders. These rsEEG markers can be used to screen HIV-positive individuals at risk of neurocognitive disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)