Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue 10, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.07.014
Keywords
ALS; Amyotrophic lateral sclerosis; CHCHD10; Genetics
Categories
Funding
- Middlemass family
- Heaton-Ellis Trust
- Motor Neurone Disease Association
- Medical Research Council
- Psychiatry Research Trust of the Institute of Psychiatry
- Guy's and St Thomas' Charity
- Wellcome Trust
- Noreen Murray Foundation
- JPND-United Kingdom
- JPND-Medical Research Council
- JPND-Economic and Social Research Council
- European Community's Health Seventh Framework Programme (FP7) [259867]
- MND Association
- MRC [G0900635, G1100695, MR/L021803/1, G0500289, G9318379, MC_G1000733, G0900688, MR/L016397/1] Funding Source: UKRI
- Medical Research Council [G0900688, MC_G1000733, G1100695, MR/L021803/1, MR/L501529/1, MR/L016397/1, G9318379, G0500289, G0900635] Funding Source: researchfish
- Medical Research Foundation [MRF-060-0003-RG-SMITH] Funding Source: researchfish
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Mutations in CHCHD10 have recently been reported as a cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. To address the genetic contribution of CHCHD10 to ALS, we have screened a cohort of 425 UK ALS +/- frontotemporal dementia patients and 576 local controls in all coding exons of CHCHD10 by Sanger sequencing. We identified a previously reported p.P34S variant that is also present in neurologically healthy controls (p = 0.58). Our results suggest that CHCHD10 is not a primary cause of ALS in UK cases. (C) 2015 Elsevier Inc. All rights reserved.
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