Review
Urology & Nephrology
Anitha Vijayan, Emaad M. Abdel-Rahman, Kathleen D. Liu, Stuart L. Goldstein, Anupam Agarwal, Mark D. Okusa, Jorge Cerda
Summary: AKI is a common complication in hospitalized and critically ill patients with increasing incidence. While most early AKI patients improve with conservative management, some may require long-term dialysis. Survivors who still need dialysis after discharge have higher mortality risk and lower quality of life.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Medicine, General & Internal
Philipp Helmer, Sebastian Hottenrott, Andreas Steinisch, Daniel Roeder, Joerg Schubert, Udo Steigerwald, Suma Choorapoikayil, Patrick Meybohm
Summary: This scoping review investigates the amount of blood loss during routine phlebotomies in adult intensive care patients and whether there are factors that can be improved in terms of patient blood management. The review demonstrates that iatrogenic blood loss significantly contributes to the development and exacerbation of hospital-acquired anemia. A comprehensive patient blood management, including blood-sparing techniques and small-volume blood collection tubes, is urgently needed to reduce avoidable blood loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Max Hahn-Klimroth, Philipp Loick, Soo-Zin Kim-Wanner, Erhard Seifried, Halvard Bonig
Summary: The study aimed to identify the minimal dataset needed to generate reasonably precise and accurate hemoglobin loss prediction tools and to validate an estimation formula. By analyzing factors such as weight, height, sex, and pre- and post-intervention hemoglobin concentration, a model with an outstanding R-2 value was derived and validated, outperforming previously proposed medical models.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Umaru Barrie, Carl A. Youssef, Mark N. Pernik, Emmanuel Adeyemo, Mahmoud Elguindy, Zachary D. Johnson, Tarek Y. El Ahmadieh, Omar S. Akbik, Carlos A. Bagley, Salah G. Aoun
Summary: Blood transfusion can have complications in medical and surgical patients, and acute anemia during surgery can affect wound healing. Current transfusion threshold guidelines may not be applicable to spine surgery patients. A systematic review of published articles found that certain transfusion trigger thresholds were associated with better outcomes and fewer complications. It is recommended to avoid blood transfusion in adult spine surgery patients if hemoglobin levels remain within a certain range during and after surgery.
Article
Orthopedics
Zbigniew Gugala, Nicola Cacciani, Gordon L. Klein, Lars Larsson
Summary: This study found that mechanical ventilation leads to gradual loss of trabecular bone and muscle in rats, showing a close correlation between the two. Mechanically ventilated patients may be at risk of compromised bone integrity and muscle weakness, necessitating preventive measures.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Medicine, General & Internal
Tina Tomic Mahecic, Roxane Brooks, Matthias Noitz, Ignacio Sarmiento, Robert Baronica, Jens Meier
Summary: For many years, physicians have not individualized the approach to allogeneic red blood cell (RBC) transfusion. Recent evidence suggests that even lower hemoglobin concentrations can be survived in the short term. To address this issue, it is important to avoid acute anemia or treat it using alternative methods. Patient blood management (PBM) can be a therapeutic concept in a clinical context, especially in intensive care units, that prevents anemia and unnecessary RBC transfusion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Nicholas A. Bosch, Anica C. Law, Jacob Bor, Laura C. Myers, Nareg H. Roubinian, Vincent X. Liu, Allan J. Walkey
Summary: In critically ill patients, a hemoglobin transfusion threshold of <7.0 g/dl compared with <10.0 g/dl improves organ dysfunction. However, it is unclear if transfusion at a hemoglobin of <7.0 g/dl is superior to no transfusion.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Clinical Neurology
Benjamin Rail, William H. Hicks, Emmanuella Oduguwa, Umaru Barrie, Mark N. Pernik, Eric Montgomery, Jonathan Tao, Yves J. Kenfack, Paula Mofor, Emmanuel Adeyemo, Derrek Edukugho, James Caruso, Carlos A. Bagley, Tarek Y. El Ahmadieh, Salah G. Aoun
Summary: This study synthesizes available evidence to propose RBC transfusion thresholds in brain tumor patients undergoing surgery. The findings suggest that a restrictive hemoglobin threshold of 8 g/dL is safe and minimizes potential complications in these patients, such as reducing length of stay, mortality, and complications.
WORLD NEUROSURGERY
(2022)
Article
Infectious Diseases
Rodopi Stamatiou, Anna Vasilaki, Dimitra Tzini, Vasiliki Tsolaki, Konstantina Zacharouli, Maria Ioannou, George Fotakopoulos, Markos Sgantzos, Demosthenes Makris
Summary: Colistin is a last-resort drug for multidrug-resistant infections, but its side effects, such as muscle toxicity, need careful monitoring. Vasoconstrictive drugs are used in intensive care to improve blood flow to vital organs. The study found that colistin treatment led to muscle abnormalities in animals, but this effect was reduced when vasoconstrictive drugs were administered. Colistin's effects on muscle depend on the septic state and the presence of vasoconstriction.
Article
Chemistry, Medicinal
Henry Oliveros, Giancarlo Buitrago
Summary: Exposure to non-steroidal anti-inflammatory drugs (NSAIDs) prior to ICU admission may increase the risk of acute kidney injury (AKI) requiring renal replacement therapy (RRT), according to an analysis of ICU patient data. However, there was no association found between NSAID exposure and other outcomes such as pneumonia.
Article
Genetics & Heredity
Bozena Bruhn-Olszewska, Hanna Davies, Daniil Sarkisyan, Ulana Juhas, Edyta Rychlicka-Buniowska, Magdalena Wojcik, Monika Horbacz, Marcin Jakalski, Pawel Olszewski, Jakub O. Westholm, Agata Smialowska, Karol Wierzba, Asa Torinsson Naluai, Niklas Jern, Lars-Magnus Andersson, Josef D. Jarhult, Natalia Filipowicz, Eva Tiensuu Janson, Sten Rubertsson, Miklos Lipcsey, Magnus Gisslen, Michael Hultstrom, Robert Frithiof, Jan P. Dumanski
Summary: The study reveals a correlation between loss of chromosome Y (LOY) and the severity of COVID-19, particularly in its impact on immune cell functions. This may explain the male bias for more severe cases of COVID-19.
Review
Clinical Neurology
Paula Mofor, Emmanuella Oduguwa, Jonathan Tao, Umaru Barrie, Yves J. Kenfack, Eric Montgomery, Derrek Edukugho, Benjamin Rail, William H. Hicks, Mark N. Pernik, Emmanuel Adeyemo, James Caruso, Tarek Y. El Ahmadieh, Carlos A. Bagley, Rafael De Oliveira Sillero, Salah G. Aoun
Summary: This study included 16 articles and found that patients with SAH who received blood transfusions were typically older, female, and had more comorbidities. Transfusion was associated with multiple postoperative complications. Analysis showed that maintaining a higher hemoglobin level after SAH was safe and could benefit patients by reducing the risk of cerebral vasospasms and improving clinical outcomes.
WORLD NEUROSURGERY
(2022)
Article
Anesthesiology
Luke J. Matzek, Andrew C. Hanson, Phillip J. Schulte, Kimberly D. Evans, Daryl J. Kor, Matthew A. Warner
Summary: Preoperative thrombocytopenia is associated with inferior outcomes in elective surgery, especially in the presence of anemia. Isolated thrombocytopenia is rare and usually identified before preoperative testing, suggesting routine screening may not be necessary for most patients.
ANESTHESIA AND ANALGESIA
(2021)
Article
Urology & Nephrology
Masatoshi Nishimoto, Miho Murashima, Maiko Kokubu, Masaru Matsui, Masahiro Eriguchi, Ken-Ichi Samejima, Yasuhiro Akai, Kazuhiko Tsuruya
Summary: The study found that AKI is strongly associated with lower hematocrit values postoperatively, and higher stages or longer duration of AKI are correlated with more severe anemia. Higher mortality rates at 3 months postoperatively were associated with AKI, and this mortality may be partially mediated by anemia following AKI, based on mediation analysis. Further research is needed to determine whether correcting anemia following AKI can improve mortality rates.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Critical Care Medicine
Don Hayes, Amy Board, Carolyn S. Calfee, Sascha Ellington, Lori A. Pollack, Hasmeena Kathuria, Michelle N. Eakin, David N. Weissman, Sean J. Callahan, Annette M. Esper, Laura E. Crotty Alexander, Nirmal S. Sharma, Nuala J. Meyer, Lincoln S. Smith, Shannon Novosad, Mary E. Evans, Alyson B. Goodman, Eleanor S. Click, Richard T. Robinson, Gary Ewart, Evelyn Twentyman
Summary: EVALI is a serious pulmonary disease, with nearly half of patients requiring ICU care, the majority needing respiratory support measures, but the vast majority surviving upon discharge. The clinical course and expert opinions provided critical insights into the treatment of this patient population.
Article
Critical Care Medicine
Joseph T. Church, Joseph A. Posluszny, Mark Hemmila, Kathleen B. To, Jill R. Cherry-Bukowiec, Jennifer Waljee
JOURNAL OF BURN CARE & RESEARCH
(2015)
Article
Surgery
Joseph Posluszny, Peter T. Rycus, Robert H. Bartlett, Milo Engoren, Jonathan W. Haft, William R. Lynch, Pauline K. Park, Krishnan Raghavendran, Lena M. Napolitano
Article
Cell Biology
Nicholas B. Johnson, Joseph A. Posluszny, Li K. He, Andrea Szilagyi, Richard L. Gamelli, Ravi Shankar, Kuzhali Muthumalaiappan
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Clinical Neurology
James S. Walter, Joseph Posluszny, Raymond Dieter, Robert S. Dieter, Scott Sayers, Kiratipath Iamsakul, Christine Staunton, Donald Thomas, Mark Rabbat, Sanjay Singh
JOURNAL OF SPINAL CORD MEDICINE
(2018)
Article
Critical Care Medicine
Joseph A. Posluszny, Peggie Conrad, Marcia Halerz, Ravi Shankar, Richard L. Gamelli
JOURNAL OF BURN CARE & RESEARCH
(2011)
Article
Cell Biology
Kirstin Howell, Joseph Posluszny, Li K. He, Andrea Szilagyi, John Halerz, Richard L. Gamelli, Ravi Shankar, Kuzhali Muthu
JOURNAL OF LEUKOCYTE BIOLOGY
(2012)
Article
Critical Care Medicine
Joseph A. Posluszny, Raymond Onders, Andrew J. Kerwin, Michael S. Weinstein, Deborah M. Stein, Jennifer Knight, Lawrence Lottenberg, Michael L. Cheatham, Saeid Khansarinia, Saraswati Dayal, Patricia M. Byers, Lawrence Diebel
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2014)
Article
Hematology
Joseph A. Posluszny, Lena M. Napolitano
Article
Critical Care Medicine
Joseph A. Posluszny, Peggie Conrad, Marcia Halerz, Ravi Shankar, Richard L. Gamelli
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
(2011)
Article
Critical Care Medicine
Joseph A. Posluszny, Kuzhali Muthumalaiappan, Ameet R. Kini, Andrea Szilagyi, Li-Ke He, Yanxia Li, Richard L. Gamelli, Ravi Shankar
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
(2011)
Article
Surgery
Noah Weingarten, Nabil Issa, Joseph Posluszny
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Surgery
Benjamin Stocker, Hannah K. Weiss, Noah Weingarten, Kathryn E. Engelhardt, Milo Engoren, Joseph Posluszny
Summary: The study found that trauma and emergency general surgery (TEGS) providers correctly predicted the discharge disposition for approximately 74% of patients, with factors such as age, Injury Severity Scores, length of stay, ICU admission, and others being associated with incorrect predictions. Furthermore, patients with risk factors for unpredictable dispositions should be flagged for better resource allocation and discharge planning.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Alexandria Byskosh, Benjamin Stocker, Daniel Yi-Ze Liu, Jennifer Li, Benjamin Gastevich, Courtney L. Devin, Giang Quach, Hannah Weiss, Joseph Posluszny
Summary: The study found that SUB patients present with more significant markers of biliary disease and have more complicated intraoperative and postoperative courses. However, the lack of biliary or vascular injuries suggests that SUB may represent a safe alternative when the critical view of safety cannot be achieved.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
KD Williams, AB Helin, J Posluszny, SP Roberts, ME Feder
