Etanercept Administration to Neonatal SH3BP2 Knock-In Cherubism Mice Prevents TNF-α-Induced Inflammation and Bone Loss

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis

(2012) Shawn Rose et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-tumor necrosis factor treatment in cherubism — Clinical, radiological and histological findings in two children

(2012) M. Hero et al.   BONE

Cherubism: best clinical practice

(2012) Maria E Papadaki et al.   Orphanet Journal of Rare Diseases

The role of SH3BP2 in the pathophysiology of cherubism

(2012) Ernst J Reichenberger et al.   Orphanet Journal of Rare Diseases

Anti-TNF therapy: Safety aspects of taking the risk

(2011) Hemda Rosenblum et al.   AUTOIMMUNITY REVIEWS

Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression

(2011) Wing-Yee Cheung et al.   BONE

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

(2011) Noam Levaot et al.   CELL

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

(2011) Sebastian Guettler et al.   CELL

Anti-TNF therapy using etanercept suppresses degenerative and inflammatory changes in skeletal muscle of older SJL/J mice

(2011) Hiroshi Nemoto et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Etanercept: efficacy and safety for approved indications

(2011) Todd A Kerensky et al.   Expert Opinion On Drug Safety

Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells

(2011) Kazuyasu Chihara et al.   GENES TO CELLS

Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro

(2011) Saja A. Al-Dujaili et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

(2011) Noam Levaot et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Tumor Necrosis Factor-α Antagonist Etanercept Decreases Blood Pressure and Protects the Kidney in a Mouse Model of Systemic Lupus Erythematosus

(2010) Marcia Venegas-Pont et al.   HYPERTENSION

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Tyrosine Phosphorylation of 3BP2 Regulates B Cell Receptor-mediated Activation of NFAT

(2009) Upasana Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of rheumatoid arthritis with anti-TNF-alpha agents: A reappraisal

(2008) Roberto Caporali et al.   AUTOIMMUNITY REVIEWS