Article
Endocrinology & Metabolism
Pia Nicolaisen, Maria Lohman Obling, Kristian Hillert Winther, Stinus Hansen, Anne Pernille Hermann, Laszlo Hegedus, Steen Joop Bonnema, Thomas Heiberg Brix
Summary: Hyperthyroidism is associated with lower volumetric bone mineral density, lower estimated bone strength, and compromised cortical microarchitecture in the radius. However, post-recovery from euthyroidism led to significant improvements in volumetric bone mineral density and cortical microarchitecture, emphasizing the importance of achieving and maintaining euthyroidism.
Article
Rheumatology
Scott Cameron Brunet, Stephanie Finzel, Klaus Engelke, Steven Kyle Boyd, Cheryl Barnabe, Sarah Lynn Manske
Summary: HR-pQCT is sensitive in detecting bone surface changes in early inflammatory arthritis (EIA) patients. Gradual degradation of joint space width proportional to symptom duration was observed in the study. Patients with EIA need close monitoring for exacerbation of arthritis and progression of periarticular bone damage.
Article
Rheumatology
Naoki Iwamoto, Ko Chiba, Shuntaro Sato, Kazuteru Shiraishi, Kounosuke Watanabe, Nozomi Oki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Naoki Hosogaya, Masako Furuyama, Makiko Kobayashi, Kengo Saito, Naoki Okubo, Masataka Uetani, Makoto Osaki, Atsushi Kawakami
Summary: This exploratory study compared the inhibition of bone erosion progression in rheumatoid arthritis patients treated with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab versus csDMARD therapy alone. Results showed that the addition of denosumab to csDMARDs may be effective in inhibiting the progression of bone erosion and improving bone micro-architecture.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Rheumatology
Camille Pinto Figueiredo, Mariana Ortega Perez, Lucas Peixoto Sales, Diogo Souza Domiciano, Marilia M. Sampaio-Barros, Valeria de Falco Caparbo, Rosa Maria Rodrigues Pereira
Summary: Lower hand grip test values are associated with higher disease activity scores and lower bone strength in rheumatoid arthritis patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Rasmus Klose-Jensen, Josephine Therkildsen, Anne-Birgitte Garm Blavnsfeldt, Bente L. Langdahl, Anna Zejden, Jesper Thygesen, Kresten Krarup Keller, Ellen-Margrethe Hauge
Summary: This study compares the accuracy of HR-pQCT and CR in classifying patients as having erosive RA, and the results show that these two methods are comparable.
Article
Immunology
Giovanni Adami, Angelo Fassio, Maurizio Rossini, Camilla Benini, Riccardo Bixio, Denise Rotta, Ombretta Viapiana, Davide Gatti
Summary: The study uncovered unique bone profile in RA, including lower bone density and distinct biomarker patterns compared to controls. Association between bone biomarkers and clinical variables were revealed, and machine learning models and principal component analysis successfully differentiated RA patients based on bone biomarker profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lucas Peixoto Sales, Bidossessi Wilfried Hounkpe, Mariana Ortega Perez, Valeria Falco Caparbo, Diogo Souza Domiciano, Eduardo Ferreira Borba, Georg Schett, Camille Pinto Figueiredo, Rosa Maria Rodrigues Pereira
Summary: This study analyzed the gene expression of classical monocytes in erosive and non-erosive rheumatoid arthritis (RA) patients and found that alterations in genes related to inflammation and bone formation might play an important role in the pathophysiology of bone erosions in RA patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Nikolas K. Knowles, Nathan Neeteson, Steven K. Boyd
Summary: This study aimed to benchmark the performance of a bone-specific, mesh-free solver using different operating systems and processors. The results indicated that under the tested conditions, using a specific number of CPU threads or GPUs can efficiently solve the models, while the convergence tolerance setting affects the solution time and result error.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Aerospace
Dongsheng Bi, Chengcheng Liu, Zhongquan Dai, Zhili Li, Ying Li, Boyi Li, Dan Li, Linjie Wang, Lina Qu, Yinghui Li, Dean Ta
Summary: This study investigates bone loss and recovery during simulated microgravity and compares the efficacy of ultrasonic transmission and backscatter techniques in assessing bone loss. The results show significant bone loss and microstructure deterioration through HR-pQCT measurements. Ultrasonic transmission measurements exhibit significant correlations with bone densities and microstructure properties. The effectiveness of the transmission technique in monitoring immobilization-induced bone loss is suggested.
MICROGRAVITY SCIENCE AND TECHNOLOGY
(2023)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Karen Mys, Peter Varga, Filip Stockmans, Boyko Gueorguiev, Verena Neumann, Olivier Vanovermeire, Caroline E. Wyers, Joop P. W. van den Bergh, G. Harry van Lenthe
Summary: This study demonstrates that CBCT is comparable to HR-pQCT in quantifying bone microstructural and mechanical parameters, with higher accuracy in predicting mechanical parameters of trabecular bone. CBCT shows promising potential as a high-resolution clinical scanning technique due to its fast scanning time and good accuracy.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Geriatrics & Gerontology
Osvaldo Daniel Messina, Maritza Vidal, Giovanni Adami, Luis Fernando Vidal, Patricia Clark, Jorge A. Morales Torres, William Lems, Cristiano Zerbini, Constanza Arguissain, Jean-Yves Reginster, Nancy E. Lane
Summary: Normal bone remodeling requires a balance between bone forming cells (osteoblasts) and bone resorbing cells (osteoclasts). In certain chronic arthritides and inflammatory diseases like rheumatoid arthritis, cytokines produced by pannus disrupt bone formation, promote bone resorption, and increase the risk of osteoporosis and fractures. Prompt remission and additional bone acting agents are necessary to mitigate these effects and preserve joint integrity and independence in daily activities.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cell Biology
Jonas Nogueira Ferreira Maciel Gusmao, Khetyma Moreira Fonseca, Bruno Sousa Pinto Ferreira, Bruno Wesley de Freitas Alves, Howard Lopes Ribeiro Junior, Mario Roberto Pontes Lisboa, Karuza Maria Alves Pereira, Mariana Lima Vale, Delane Viana Gondim
Summary: Electroacupuncture (EA) has shown anti-inflammatory and anti-resorptive effects in experimental studies. In this rat study involving periodontitis and rheumatoid arthritis (RA), EA reduced pain intensity and inflammation related to periodontitis in arthritic rats, but did not prevent alveolar bone loss (ABL). EA was more effective in reducing ABL and bone radiographic density (BRD) in the presence of periodontitis.
Article
Plant Sciences
Xia Liu, Mingchun Huang, Lijuan Wang, Chen Yang, Mei Zhang, Qin Wang
Summary: Wine-processed Curculigo orchioides demonstrated stronger efficacy in alleviating bone destruction in rheumatoid arthritis compared to raw Curculigo orchioides. This may be attributed to the ability of wine-processed Curculigo orchioides to regulate multiple metabolic pathways in reducing inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Letter
Rheumatology
Dafna D. Gladman, Philip J. Mease, Paul Bird, Enrique R. Soriano, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Cinty Gong, Evan Leibowitz, Denis Poddubnyy, Lai-Shan Tam, Philip S. Helliwell, Arthur Kavanaugh, Atul A. Deodhar, Mikkel Ostergaard, Xenofon Baraliakos
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Philip J. Mease, Iain B. McInnes, Lai-Shan Tam, Raji Rajalingam, Steve Peterson, Fareen Hassan, Soumya D. Chakravarty, Christine Contre, Alison Armstrong, Wolf-Henning Boehncke, Christopher Ritchlin
Summary: The objective of this study was to update the network meta-analysis (NMA) comparing guselkumab with other targeted therapies for PsA. The results showed that guselkumab demonstrated better skin efficacy than most other PsA treatments and had comparable ACR responses to most agents.
Article
Gastroenterology & Hepatology
Jacky C. L. Ho, Joyce W. Y. Mak, Terry C. F. Yip, Hong Man Lam, Tsz Yan Cheng, Tsz On Lam, Lai Shan Tam, Man Fai Law, Carmen K. M. Cheung, Siew C. Ng, Vincent W. S. Wong, Grace L. H. Wong
Summary: This study aimed to evaluate the risk of alanine aminotransferase (ALT) flare in patients with past hepatitis B virus (HBV) infection while using biological therapies. The results showed a non-significant increase in risk of ALT flare among the HBV-exposed group. The use of prednisolone, male sex, and concomitant immunosuppressants were identified as risk factors for ALT flare.
LIVER INTERNATIONAL
(2023)
Article
Rheumatology
Tsz On Lam, Isaac T. Cheng, Steven H. Lam, Chi Chiu Mok, Carmen T. Ho, Tommy T. Cheung, Virginia W. Lao, Hin Ting Pang, Chi Hung To, Cheuk Wan Yim, Alexandra Ng, Kitty Y. Kwok, Ka Lai Lee, Shirley K. Ying, Man Choi Wan, Jolly M. Lee, Lai-Shan Tam
Summary: This study aimed to investigate whether the excess cardiovascular disease risk in rheumatoid arthritis (RA) patients could be reduced by using a treat-to-target (T2T) approach to suppress inflammation. The results showed that early RA patients managed by T2T strategy had a similar incidence of cardiovascular events (CVE) compared to non-RA individuals and a historical RA cohort. Therefore, T2T strategy can effectively lower the cardiovascular risk in RA patients.
Article
Nutrition & Dietetics
Yingzhao Jin, Ho So, Ester Cerin, Anthony Barnett, Sumaira Mubarik, Kamal Hezam, Xiaoqi Feng, Ziyue Wang, Junjie Huang, Chenwen Zhong, Khezar Hayat, Fang Wang, Ai-Min Wu, Suowen Xu, Zhiyong Zou, Lee-Ling Lim, Jiao Cai, Yimeng Song, Lai-shan Tam, Dongze Wu
Summary: The disease burden attributable to metabolic risk factors is rapidly increasing in China, especially in older people. This study estimated the pattern and trend of six metabolic risk factors in China from 1990 to 2019, and compared the disease burden among G20 countries. The results showed that population aging continuously accelerates the metabolic risk factor driven disease burden in China.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Lin-Hong Shi, Steven H. H. Lam, Ho So, Crystal Y. Y. Chan, Tena K. K. Li, Cheuk-Chun Szeto, Lai-Shan Tam
Summary: This study found that patients with axial spondyloarthritis (axSpA) have a higher risk of cardiovascular disease, particularly hypertension. Through adjusting for traditional cardiovascular risk factors, the study determined that longer disease duration, delayed diagnosis, and higher ESR levels are independent predictors associated with the development of hypertension. These findings highlight the importance of routine hypertension screening in axSpA patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Engineering, Biomedical
Xuechen Zhang, Isaac Cheng, Shaojun Liu, Chenrui Li, Jing-Hao Xue, Lai-Shan Tam, Weichuan Yu
Summary: This paper presents an automatic erosion detection method based on HR-pQCT images, which includes constructing a closed cortical surface and analyzing curvature information to detect erosions. The results show that the proposed method achieves satisfactory and consistent performance compared to annotations provided by medical experts.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Article
Multidisciplinary Sciences
Jiang Yue, Priscilla C. H. Wong, Ying Zhang, Feng Peng, James F. Griffith, Jiankun Xu, Fan Xiao, Tena K. Li, Vivian Hung, Ling Qin, Lai-Shan Tam
Summary: The purpose of this prospective study is to compare the Chinese visceral adiposity index (CVAI) between early rheumatoid arthritis (ERA) patients and healthy controls, and to assess the relationship between CVAI and bone microstructure using HR-pQCT in ERA patients. The study found that CVAI was significantly higher in the ERA group compared to the controls, and a higher CVAI was associated with higher ESR levels and lower cortical vBMD. Linear regression analysis showed that a higher baseline CVAI was an independent predictor of lower cortical vBMD and greater reduction in trabecular vBMD.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Ho So, Tsz On Lam, Huan Meng, Steven Ho Man Lam, Lai-Shan Tam
Summary: The use of glucocorticoids (GC) increases the risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) patients, but there is controversy regarding the threshold dose and duration of GC use that will increase the CVE rate. This study found that a daily prednisolone dose ≥5 mg significantly increased the risk of CVE, while a daily dose below 5 mg was not associated with CVE risk.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Xiujuan Hou, Yung-Heng Lee, Tangliang Qian, Connie Chen, Lai-Shan Tam
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Health Care Sciences & Services
Ho So, Evelyn Chow, Isaac T. Cheng, Sze-Lok Lau, Tena K. Li, Cheuk-Chun Szeto, Lai-Shan Tam
Summary: Patients with systemic lupus erythematous had similar disease control at 1 year with telemedicine follow-up compared to standard care, but in-person visits were needed, especially in patients with unstable disease.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James F. Griffith, Cynthia T. P. Leung, Jeremiah C. H. Lee, Jason C. S. Leung, David K. W. Yeung, Patrick S. H. Yung
Summary: This study used a practical positional MRI protocol to evaluate tibiofemoral translation and rotation in normal and injured knees. The results showed that ACL tear knees exhibited increased tibial anterior translation and decreased external rotation compared to normal knees. Multidirectional malalignment was more common in ACL tear knees.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James Francis Griffith, Samuel K. K. Ling, Thomas Tischer, Marc-Andre Weber
Summary: This article suggests a similar approach to evaluate osteochondral lesions of the talar dome both before and after surgery. It reviews the etiology, natural history, and treatment of these lesions, with a focus on imaging appearances. High-resolution magnetic resonance imaging, combined with ankle traction and a small surface coil, is recommended to optimize the visibility of clinically relevant features.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2022)
Article
Rheumatology
Ho So, Tena Li, Vivien Chan, Lai-Shan Tam, Paul K. S. Chan
Summary: COVID-19 vaccines produced satisfactory but impaired humoral response in SLE patients compared to controls, which was dependent on the immunosuppressive medications used and type of vaccines received. No new short-term safety signals were noted. Booster dose is encouraged.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Article
Rheumatology
Lin-Hong Shi, Steven H. Lam, Ho So, Edmund K. Li, Tena K. Li, Cheuk-Chun Szeto, Lai-Shan Tam
Summary: Increased inflammatory burden as reflected by elevated ESR levels (ESR >= 20) was associated with increased risk of CVE, while the use of NSAIDs and DMARDs were not.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)