Article
Endocrinology & Metabolism
R. M. Plett, T. D. Kemp, L. A. Burt, E. O. Billington, D. A. Hanley, S. K. Boyd
Summary: The study developed and validated a finite element approach for longitudinal HR-pQCT studies that reduced variability and improved measurement accuracy by using 3D image registration to account for misalignment. Results showed that 3D rigid-body registration improved measurement precision in ex vivo samples and minimized longitudinal in vivo reproducibility for failure load estimates, making it suitable for assessing the effects of interventions on bone strength in longitudinal studies.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Nikolas K. Knowles, Danielle E. Whittier, Bryce A. Besler, Steven K. Boyd
Summary: Injury to the ACL increases the risk of osteoarthritis, with clinical QCT-FEMs shown to accurately replicate HR-pQCT FEM changes in bone quality.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
Melissa S. A. M. Bevers, Frans L. Heyer, Caroline E. Wyers, Bert van Rietbergen, Piet P. M. M. Geusens, Heinrich M. J. Janzing, Okke Lambers Heerspink, Martijn Poeze, Joop P. van den Bergh
Summary: This study investigates the contribution of lower-mineralized tissue to the stiffness of fractured distal radii during healing. The results suggest that the contribution of lower-mineralized tissue is minor but changes significantly around the time of cast removal. This finding has clinical relevance and provides a more complete understanding of strength recovery post-fracture.
Article
Endocrinology & Metabolism
M. Revel, F. Bermond, F. Duboeuf, D. Mitton, H. Follet
Summary: Although HR-pQCT allows for assessment of bone microstructure and strength to evaluate fracture risk, it does not show clear improvement in accuracy compared to DXA measurements. Changes in loading conditions do not enhance the prediction of radius fracture risk based on ex vivo experiments, as demonstrated by similar ROC curves and accuracies with different loading conditions.
Article
Computer Science, Interdisciplinary Applications
Nikolas K. Knowles, Nathan Neeteson, Steven K. Boyd
Summary: This study aimed to benchmark the performance of a bone-specific, mesh-free solver using different operating systems and processors. The results indicated that under the tested conditions, using a specific number of CPU threads or GPUs can efficiently solve the models, while the convergence tolerance setting affects the solution time and result error.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Transplantation
Priscila Ligeiro Goncalves Esper, Fernanda Guedes Rodrigues, Thalita Lima Melo, Milene Subtil Ormanji, Carlos M. Campos, Jackeline Couto Alvarenga, Valeria de Falco Caparbo, Aluizio Barbosa Carvalho, Rosa Maria Rodrigues Pereira, Ita Pfeferman Heilberg
Summary: This study investigated bone mineral density, bone microarchitecture, and biomechanical properties in young stone formers using HR-pQCT and FEA techniques. The findings showed that stone formers had lower trabecular number and higher trabecular separation, with more pronounced bone microarchitecture impairment observed in female patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Engineering, Biomedical
Denis Schenk, Michael Indermaur, Mathieu Simon, Benjamin Voumard, Peter Varga, Michael Pretterklieber, Kurt Lippuner, Philippe Zysset
Summary: The study refined and experimentally validated a homogenized finite element method for in vivo prediction of bone strength and stiffness at the distal segments of the radius and the tibia using a unified set of material properties. The identified material properties allowed for accurate prediction of stiffness and failure load, demonstrating excellent agreement with experimental results at both measurement sites.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Endocrinology & Metabolism
Sanchita Agarwal, Stephanie Shiau, Mafo Kamanda-Kosseh, Mariana Bucovsky, Nayoung Kil, Joan M. M. Lappe, Julie Stubby, Robert R. R. Recker, X. Edward Guo, Elizabeth Shane, Adi Cohen
Summary: Premenopausal women with idiopathic osteoporosis (PreMenIOP) have significant deficits in skeletal microstructure. Sequential treatment with teriparatide and denosumab improves bone mineral density and microarchitecture in PreMenIOP. Specifically, after teriparatide treatment, improvements in tibial and radial microarchitecture, density and whole-bone stiffness were observed. After denosumab treatment, increases in volumetric bone mineral density, microstructure and bone strength were seen at both tibia and radius. The findings support the use of sequential treatment with teriparatide followed by denosumab in PreMenIOP.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Felix N. Schmidt, Constantin Schmidt, Julian Delsmann, Michael Amling, Florian Barvencik
Summary: Hypophosphatasia (HPP) is an inborn disease causing rare osteomalacia. Identifying HPP patients at high risk for fractures or skeletal manifestations is challenging. This study used HR-pQCT and FEA to assess bone microarchitecture and mechanical performance in HPP patients, revealing distinctive patterns of skeletal manifestations. HR-pQCT appears to be clinically relevant for identifying HPP patients with increased fracture risk, particularly at the distal radius.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Orthopedics
Camille P. Figueiredo, Mariana O. Perez, Lucas Peixoto Sales, Ana Cristina Medeiros, Valeria F. Caparbo, Rosa M. R. Pereira
Summary: This study found that BMD of MCP head was independently associated with the volume of bone erosion, suggesting it can be used to analyze and monitor bone destruction, as well as to evaluate treatment response in RA patients.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Rheumatology
Axel P. Villani, Stephanie Boutroy, Celine Coutisson, Marie-Christine Carlier, Lois Barets, Hubert Marotte, Bertrand Richert, Roland D. Chapurlat, Denis Jullien, Cyrille B. Confavreux
Summary: This study found that onycholysis may be associated with early bone erosions of the DIP joint, which can impact the development of PsA. In the ONY group, there were significantly more bone erosions compared to the PSO group.
Article
Endocrinology & Metabolism
Heather M. Macdonald, Mikko Maatta, Leigh Gabel, Kishore Mulpuri, Heather A. McKay
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Sport Sciences
Alejandro Gomez-Bruton, Leigh Gabel, Lindsay Nettlefold, Heather Macdonald, Douglas Race, Heather McKay
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2019)
Article
Endocrinology & Metabolism
Leigh Gabel, Heather M. Macdonald, Lindsay A. Nettlefold, Heather A. McKay
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Endocrinology & Metabolism
Vina P. S. Tan, Heather M. Macdonald, Leigh Gabel, Heather A. McKay
ARCHIVES OF OSTEOPOROSIS
(2018)
Article
Pediatrics
Joanie Sims-Gould, Douglas L. Race, Heather Macdonald, Kristin M. Houghton, Ciaran M. Duffy, Lori B. Tucker, Heather A. Mckay
PEDIATRIC RHEUMATOLOGY
(2018)
Article
Pediatrics
Jennifer McConnell-Nzunga, Path-Jean Naylor, Heather M. Macdonald, Ryan E. Rhodes, Scott M. Hofer, Heather A. McKay
Review
Sport Sciences
Samantha M. Gray, Heather A. McKay, Lindsay Nettlefold, Douglas Race, Heather M. Macdonald, Patti-Jean Naylor, Joanie Sims-Gould
Summary: The review found that older adult physical activity intervention studies reported implementation indicators and frameworks, but lacked specific indicators for scale-up evaluation. There is a relationship between implementation indicators and individual health outcomes, but further research is needed to explore influencing factors.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Environmental Sciences
Lindsay Nettlefold, Patti-Jean Naylor, Heather M. Macdonald, Heather A. McKay
Summary: The study examined the implementation and scale-up of the Action Schools! BC program over 11 years, evaluating the impact on teachers' physical activity delivery and students' physical activity and cardiorespiratory fitness. Findings showed that intervention group teachers provided more physical activity in the first year and students in the intervention group had improved cardiorespiratory fitness compared to the control group. Despite some challenges, scaling up school-based physical activity models is feasible and beneficial for children's health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Geriatrics & Gerontology
Heather M. Macdonald, Lindsay Nettlefold, Adrian Bauman, Joanie Sims-Gould, Heather A. McKay
Summary: This study assessed the convergent validity and responsiveness to change of a single-item physical activity measure in adults aged 60 years and older. The results showed that the single-item measure had moderate correlations with the CHAMPS questionnaire at baseline, but weaker correlations for change in physical activity. The effect size for physical activity change was larger for the single-item measure than for the CHAMPS questionnaire, indicating its reliability as a tool for intervention and scale-up studies with older adults.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2022)
Article
Sport Sciences
Jennifer Mcconnell-Nzunga, Leigh Gabel, Heather M. M. Macdonald, Ryan E. E. Rhodes, Scott M. M. Hofer, Patti-Jean Naylor, Heather A. A. Mckay
Summary: Physical activity, sedentary time, and energy intake are associated with fat mass accrual in children and youth. Girls have a higher rate of fat mass accrual than boys, which continues to increase during adolescence. For boys, an increase in moderate-to-vigorous physical activity is negatively associated with fat mass. For girls, higher levels of physical activity throughout adolescence are associated with lower fat mass.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Education & Educational Research
Heather M. Macdonald, Minsoo Kang
MEASUREMENT IN PHYSICAL EDUCATION AND EXERCISE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Heather McKay, Heather M. Macdonald, Lindsay Nettlefold, Katie M. Weatherson, Samantha Gray, Adrian Bauman, Karim Khan, Joanie Sims Gould
Summary: The health-promoting intervention "Choose to Move" was successfully scaled-up in British Columbia, Canada. The intervention maintained its effectiveness and successfully reduced social isolation in older adults.
Article
Endocrinology & Metabolism
Heather J. Macdonald, Evelyn Maan, Claudie Berger, Helene C. F. Cote, Melanie C. M. Murray, Neora C. Pick, Jerilynn Prior
Summary: This prospective study compared the 10-year change in bone mineral density (BMD) between women living with HIV (WLWH) and HIV-negative women. The study found no significant differences in baseline and 10-year change in BMD between the two groups, after adjusting for osteoporosis risk factors. However, WLWH had a higher prevalence of low-trauma fracture and major osteoporotic fracture at baseline. Further large-scale studies are needed to confirm these findings.
Article
Geriatrics & Gerontology
Venessa Wong, Thea Franke, Heather Mckay, Catherine Tong, Heather Macdonald, Joanie Sims-Gould
Summary: This study explores the cultural adaptation of community-based health-promoting programs for racially minoritized, immigrant older adult populations. It found that prioritizations, familiarity, and literacy are the dominant cultural and immigration-related factors influencing the adaptation of health-promoting programs for Chinese older adults. These findings have important implications for future program development and delivery.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Article
Public, Environmental & Occupational Health
Heather A. McKay, Lindsay Nettlefold, Joanie Sims-Gould, Heather M. Macdonald, Karim M. Khan, Adrian Bauman
Summary: The study found that some older adults were able to maintain the health benefits of the Choose to Move intervention 12 months after its end, such as reduced loneliness, improved mobility, and muscle strength. However, older participants did not maintain the intervention-related gains in physical activity levels and social isolation.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2021)