Article
Endocrinology & Metabolism
Vittoria Favero, Cristina Eller-Vainicher, Valentina Morelli, Elisa Cairoli, Antonio Stefano Salcuni, Alfredo Scillitani, Sabrina Corbetta, Silvia Della Casa, Giovanna Muscogiuri, Luca Persani, Iacopo Chiodini
Summary: This study evaluated the prevalence and incidence of vertebral fractures in patients with adrenal incidentalomas and mild autonomous cortisol secretion. The results showed that patients with adrenal incidentalomas and mild autonomous cortisol secretion are at higher risk of vertebral fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Eric Seidel, Julia Schewe, Junhui Zhang, Hoang An Dinh, Sofia K. Forslund, Lajos Marko, Nicole Hellmig, Joerg Peters, Dominik N. Muller, Richard P. Lifton, Timothy Nottoli, Gabriel Stoelting, Ute Scholl
Summary: Gain-of-function mutations in the CACNA1H gene lead to familial hyperaldosteronism and early-onset hypertension, while knockout of the gene can be compensated for by activating alternative calcium entry pathways for aldosterone production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Linghui Kong, Xiaofeng Tang, Yuanyuan Kang, Lei Dong, Jianhua Tong, Jianzhong Xu, Ping-jin Gao, Ji-guang Wang, Weili Shen, Limin Zhu
Summary: The expression of NCC and pNCC in urinary extracellular vesicles (uEVs) varies in different subtypes and genotypes of primary aldosteronism (PA) and can be used to select candidates for adrenal venous sampling (AVS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Rola Al Ghali, Carla El-Mallah, Omar Obeid, Ola El-Saleh, Linda Smail, Dalia Haroun
Summary: The urinary excretion of calcium, magnesium, and phosphorus among Emirati schoolchildren was found to be similar to levels in other countries. Fluoride excretion suggests that Emirati children have a low risk of fluorosis. The slightly elevated level of urinary iodine excretion requires close monitoring of salt iodization to prevent harmful effects of iodine overconsumption.
Article
Endocrinology & Metabolism
Yuta Tezuka, Adina F. Turcu
Summary: This study found that only a small percentage of patients with PA and LRH treated with MRAs in an academic outpatient practice were evaluated for target renin, and less than half of them achieved target renin. Lower baseline serum potassium, lower MRA doses, and beta-blocker use were associated with lower odds of achieving target renin in PA, while male sex was associated with target renin in LRH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Anesthesiology
Chengyue Ji, Yuluo Rong, Jiaxing Wang, Shunzhi Yu, Guoyong Yin, Jin Fan, Pengyu Tang, Dongdong Jiang, Wei Liu, Fangyi Gong, Xuhui Ge, Weihua Cai
Summary: In the aging population, secondary vertebral compression fractures following primary osteoporotic vertebral compression fractures are a significant concern. Age, history of nonspinal fractures, and Hounsfield units value of L1 were identified as independent risk factors associated with secondary vertebral compression fractures.
Article
Endocrinology & Metabolism
Tracy Ann Williams, Celso E. Gomez-Sanchez, William E. Rainey, Thomas J. Giordano, Alfred K. Lam, Alison Marker, Ozgur Mete, Yuto Yamazaki, Maria Claudia Nogueira Zerbini, Felix Beuschlein, Fumitoshi Satoh, Jacopo Burrello, Holger Schneider, Jacques W. M. Lenders, Paolo Mulatero, Isabella Castellano, Thomas Knosel, Mauro Papotti, Wolfgang Saeger, Hironobu Sasano, Martin Reincke
Summary: The HISTALDO consensus is useful to standardize nomenclature and achieve consistency among pathologists for the histopathologic diagnosis of unilateral PA. CYP11B2 immunohistochemistry should be incorporated into the routine clinical diagnostic workup to localize the likely source of aldosterone production.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Davis Sam, Gregory A. Kline, Benny So, Janice L. Pasieka, Adrian Harvey, Alex Chin, Stefan J. Przybojewski, Alexander A. Leung
Summary: The study found that patients with unilateral PA and normal adrenal imaging had favorable outcomes following adrenalectomy, with a majority of patients showing complete or partial response in both biochemical and clinical outcomes. Therefore, patients with lateralizing disease should be considered for surgery even if their adrenal imaging appears normal.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Hiroki Teragawa, Chikage Oshita, Yuichi Orita, Kunihiro Hashimoto, Hirofumi Nakayama, Yuto Yamazaki, Hironobu Sasano
Summary: Adrenal incidentaloma (AI) is frequently encountered in clinical practice, and primary aldosteronism (PA) or subclinical Cushing's syndrome (SCS) are common causes. Coexistence of PA and SCS has been reported. We describe a case where both PA and SCS were confirmed by histopathological examination after laparoscopic adrenalectomy in a 58-year-old man presenting with lower right abdominal pain.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Endocrinology & Metabolism
Minggang Huang, Di Yang, Yan Zhang, Yuqing Zhang, Yue Mu
Summary: This study investigates the feasibility of dual-energy CT energy imaging parameters as a novel biomarker in identifying bilateral adrenal dominant lesions in patients with primary aldosteronism (PA). The results show that the dual-energy CT energy spectrum imaging parameters have high sensitivity and specificity in distinguishing bilateral adrenal lesions, and can serve as a complementary method to adrenal venous sampling (AVS) in the diagnosis of PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study aimed to explore the role of two confirmatory tests in the subtype diagnosis of primary aldosteronism (PA). The results showed that patients with discordant results between confirmatory tests are highly likely to have a bilateral subtype on adrenal vein sampling (AVS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Seung Shin Park, Chang Ho Ahn, Sang Wan Kim, Ji Won Yoon, Jung Hee Kim
Summary: Patients with bilateral primary aldosteronism (PA) are more obese and have higher visceral fat area (VFA) levels than those with lateralized PA. Despite a milder form of PA, this metabolically unfavorable visceral fat distribution may lead to a higher metabolic risk in patients with bilateral PA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Vittoria Favero, Arianna Cremaschi, Chiara Parazzoli, Alberto Falchetti, Agostino Gaudio, Luigi Gennari, Alfredo Scillitani, Fabio Vescini, Valentina Morelli, Carmen Aresta, Iacopo Chiodini
Summary: Mild hypercortisolism refers to abnormal cortisol secretion without the overt manifestations of Cushing's syndrome. It is commonly found in patients with adrenal incidentalomas and incidentally discovered pituitary tumors. The pathogenesis of hypercortisolism of pituitary origin is still unclear, while advances have been made in understanding the genetic background of adrenal adenomas causing mild hypercortisolism. The clinical consequences of mild hypercortisolism include bone fragility, arterial hypertension, subclinical atherosclerosis, cardiovascular remodeling, dyslipidemia, glucose metabolism impairment, visceral adiposity, infections, muscle damage, mood disorders, and coagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
C. Okoye, F. Niccolai, S. Rogani, B. Lemmi, U. Peta, S. Del Vecchio, V. Morelli, N. Caraccio, V. Calsolaro, F. Monzani
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Timo Deutschbein, Giuseppe Reimondo, Guido Di Dalmazi, Irina Bancos, Jekaterina Patrova, Dimitra Argyro Vassiliadi, Anja Barac Nekic, Miguel Debono, Pina Lardo, Filippo Ceccato, Luigi Petramala, Alessandro Prete, Iacopo Chiodini, Miomira Ivovic, Kalliopi Pazaitou-Panayiotou, Krystallenia Alexandraki, Felicia Alexandra Hanzu, Paola Loli, Serkan Yener, Katharina Langton, Ariadni Spyroglou, Tomaz Kocjan, Sabina Zacharieva, Nuria Valdes, Urszula Ambroziak, Mari Suzuki, Mario Detomas, Soraya Puglisi, Lorenzo Tucci, Danae Anastasia Delivanis, Dimitris Margaritopoulos, Tina Dusek, Roberta Maggio, Carla Scaroni, Antonio Concistre, Cristina Lucia Ronchi, Barbara Altieri, Cristina Mosconi, Aristidis Diamantopoulos, Nicole Marie Iniguez-Ariza, Valentina Vicennati, Anna Pia, Matthias Kroiss, Gregory Kaltsas, Alexandra Chrisoulidou, Ljiljana Marina, Valentina Morelli, Wiebke Arlt, Claudio Letizia, Marco Boscaro, Antonio Stigliano, Darko Kastelan, Stylianos Tsagarakis, Shobana Athimulam, Uberto Pagotto, Uwe Maeder, Henrik Falhammar, John Newell-Price, Massimo Terzolo, Martin Fassnacht
Summary: The autonomy of cortisol secretion in patients with adrenal incidentalomas is associated with increased all-cause mortality. Additionally, patients with non-functioning adenomas have significantly lower rates of cardiometabolic comorbidities.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Editorial Material
Nutrition & Dietetics
Francesco Bertoldo, Luisella Cianferotti, Marco Di Monaco, Alberto Falchetti, Angelo Fassio, Davide Gatti, Luigi Gennari, Sandro Giannini, Giuseppe Girasole, Stefano Gonnelli, Nazzarena Malavolta, Salvatore Minisola, Mario Pedrazzoni, Domenico Rendina, Maurizio Rossini, Iacopo Chiodini
Article
Endocrinology & Metabolism
Sofia Frigerio, Giulia Carosi, Emanuele Ferrante, Elisa Sala, Elisa Polledri, Silvia Fustinoni, Bruno Ambrosi, Iacopo Chiodini, Giovanna Mantovani, Valentina Morelli, Maura Arosio
Summary: This study aimed to assess clinical and biochemical modifications in patients shifted from cortisone acetate (CA) to modified-release hydrocortisone (MRH). The results showed that patients shifted to MRH treatment had improved blood pressure control and symptoms of over- or undertreatment, but no significant changes in glucose metabolism or total cortisol exposure were observed. Therefore, a dose reduction may be needed when shifting from CA to MRH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Vittoria Favero, Cristina Eller-Vainicher, Iacopo Chiodini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Francesca Birtolo, Simone Antonini, Andrea Saladino, Benedetta Zampetti, Elisabetta Lavezzi, Iacopo Chiodini, Gherardo Mazziotti, Andrea G. A. Lania, Renato Cozzi
Summary: Secondary Adrenal Insufficiency (SAI) is a condition characterized by low ACTH secretion due to hypothalamus or pituitary disease or injury. The evaluation of SAI is challenging due to non-specific symptoms, rarity, and pitfalls associated with laboratory tests. The gold standard test for assessing the HPA axis is the insulin tolerance test, but the ACTH stimulation test is safer and well-tolerated, although its diagnostic accuracy varies.
Article
Biology
Giorgia Grassi, Elisa Cairoli, Lucrezia Maria Silvana Gentile, Iacopo Chiodini, Marta Zampogna, Alberto Ghielmetti, Letizia Corinna Morlacchi, Valeria Rossetti, Lorenzo Rosso, Ilaria Righi, Mario Nosotti, Maura Arosio, Francesco Blasi, Cristina Eller Vainicher
Summary: Based on our study, the skeletal outcomes in long-term survivors (>5 years) after lung transplantation were similar between patients with cystic fibrosis (CF) and those with non-cystic fibrosis (nCF), with a lower incidence of fractures compared to the first two years post-transplant. Bone mineral density and trabecular bone score remained stable after the second year post-transplant.
Article
Endocrinology & Metabolism
Morelli Valentina, Elli Francesca Marta, Frigerio Sofia, Vena Walter, Palmieri Serena, Lucca Camilla, Maffini Maria Antonia, Contarino Andrea, Bagnaresi Francesca, Mantovani Giovanna, Arosio Maura
Summary: This study aimed to evaluate the prevalence of ARMC5 genetic defects in patients with bilateral adrenal incidentaloma (BAI) and explore the possible genotype-phenotype correlations. The results showed that the prevalence of germline ARMC5 pathogenic variants was 18.8% in BAI patients with mild autonomous cortisol secretion (MACS+). Somatic ARMC5 pathogenic variants were also found in adrenal tissue of patients without germline ARMC5 variants, indicating their involvement in adrenal tumor development.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Vittoria Favero, Cristina Eller-Vainicher, Valentina Morelli, Elisa Cairoli, Antonio Stefano Salcuni, Alfredo Scillitani, Sabrina Corbetta, Silvia Della Casa, Giovanna Muscogiuri, Luca Persani, Iacopo Chiodini
Summary: This study evaluated the prevalence and incidence of vertebral fractures in patients with adrenal incidentalomas and mild autonomous cortisol secretion. The results showed that patients with adrenal incidentalomas and mild autonomous cortisol secretion are at higher risk of vertebral fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Rosa Catalano, Barbara Altieri, Anna Angelousi, Maura Arosio, Francesca Bravi, Letizia Canu, Giorgio A. Croci, Mario Detomas, Emanuela Esposito, Emanuele Ferrante, Stefano Ferrero, Carmina T. Fuss, Gregory Kaltsas, Otilia Kimpel, Laura-Sophie Landwehr, Michaela Luconi, Valentina Morelli, Gabriella Nesi, Emma Nozza, Silviu Sbiera, Andreea L. Serban, Cristina L. Ronchi, Giovanna Mantovani, Erika Peverelli
Summary: In adrenocortical carcinomas, the expression of cytoskeleton protein filamin A (FLNA) is associated with tumor aggressiveness and patient survival. High FLNA expression is linked to lower tumor stage, lower scores, and longer overall survival in adrenal cortical carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Vittoria Favero, Alessandro Prete, Alessandra Mangone, Yasir S. Elhassan, Valentina Pucino, Miriam Asia, Rowan Hardy, Iacopo Chiodini, Cristina L. Ronchi
Summary: This study evaluated the hematological alterations in benign adrenocortical tumors with different degrees of cortisol excess. It found that the degree of cortisol excess was correlated with an increase in leukocytes, neutrophils, and monocytes. Additionally, the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index were altered in patients with mild autonomous cortisol secretion (MACS) and adrenal Cushing's syndrome.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Meeting Abstract
Geriatrics & Gerontology
C. Alberio, R. Mirsepanj, S. Vai, F. Broggi, I. Chiodini, C. Dosi, R. Masson, A. Falchetti
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Iacopo Chiodini, Davide Gatti, Davide Soranna, Daniela Merlotti, Christian Mingiano, Angelo Fassio, Giovanni Adami, Alberto Falchetti, Cristina Eller-Vainicher, Maurizio Rossini, Luca Persani, Antonella Zambon, Luigi Gennari
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
