Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Endocrinology & Metabolism
B. Hanusch, M. Prediger, S. P. Tuck, J. Walker, R. McNally, H. K. Datta
Summary: Men with low-trauma wrist fractures have higher bone turnover markers and lower bone mineral density compared to healthy controls. Bone turnover markers are negative predictors of bone mineral density and fracture risk in these men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
N. Binkley, E. Orwoll, R. Chapurlat, B. L. Langdahl, B. B. Scott, H. Giezek, A. C. Santora
Summary: Odanacatib showed significant efficacy in improving bone mineral density and reducing bone resorption in men with osteoporosis. However, its development was discontinued due to an increased risk of stroke in another study.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Courtney L. Robertson, Gaurav Ghosh, Patrick Fitzgerald, Graeme J. Hankey, Itamar Levinger, Jonathan Golledge, Osvaldo P. Almeida, Leon Flicker, Peter R. Ebeling, Bu B. Yeap
Summary: Evaluation of bone turnover markers including ucOC in serum can provide risk information for all-cause mortality in older men, and higher levels of ucOC, PINP, and CTX are associated with increased risk of all-cause mortality.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin Liu, Jian-Di Chen, Ping Li, Jian-Wei Liao, Jia-Xin Feng, Zi-Yang Chen, Zhi-Yuan Cai, Wei Li, Xiao-Jun Chen, Zhi-Hai Su, Hai Lu, Shao-Lin Li, Ya-Jun Ma
Summary: Compositional MR imaging technique can comprehensively assess osteoporosis in the lumbar spine by quantifying proton fractions for water components and showing good clinical diagnostic capability.
EUROPEAN RADIOLOGY
(2023)
Article
Anatomy & Morphology
Subok Kim, Sanghun Jang, Onseok Lee
Summary: This study aimed to objectively diagnose osteoporosis (OP) by visualizing micro-damage caused by OP using synchrotron radiation-based mu CT (SR-mu CT). The results showed that the OVX group had smaller cortical bone volume and thickness, as well as lower trabecular bone volume/total volume compared to the SHAM group. In addition, the SHAM group had larger canal volume and lacuna volume than the OVX group.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Medical Laboratory Technology
Gregory A. Kline, Daniel T. Holmes
Summary: Bone turnover markers (BTM) are important for understanding the effect of anti-resorptives on osteoclast activity. Post-hoc trial data suggests that a 40% reduction in BTM may represent an appropriate response to therapy. However, applying this target threshold in individual patients is problematic due to measurement uncertainty and natural variation.
CLINICAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Mitsuru Doi, Ko Chiba, Narihiro Okazaki, Choko Kondo, Shuta Yamada, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: The study found that age-related changes in bone microstructure in men involve decreases in trabecular and cortical volumetric bone density, decreased trabecular number, cavitation of the trabecular structure, and increased cortical porosity. Femoral aBMD was strongly correlated with bone microstructure in the tibia, while biochemical markers showed almost no relationships with bone microstructure.
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Pramod B. Umarji, Pankaj Verma, Vivek Garg, Marian Schini, Richard Eastell
Summary: This study conducted a 6-month randomized controlled trial on young Indian women aged 25 to 44, with the results showing favorable changes in bone metabolism and calcium homeostasis, indicating potential improvements in bone health.
Article
Pharmacology & Pharmacy
Qi Liu, Jian Zhou, Zhou Yang, Chuhai Xie, Yan Huang, Long Ling, Yanming Cao, Hailan Hu, Yue Hua
Summary: The study demonstrated that ginsenoside-Rb2 attenuates bone loss induced by KD and maintains biomechanical properties. This was achieved by inhibiting bone resorption and promoting osteogenic differentiation, suggesting ginsenoside as a potential option for KD-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Grethe Jonasson, Azar Hassani-Nejad, Magnus Hakeberg
Summary: In this study, the association between mandibular cortex parameters and fracture risk in older adults was investigated. The findings showed that severely eroded cortex and cortex thickness < 3 mm were significant predictors for fracture risk. The results also indicated differences in cortical parameters between men and women, with significant associations found in older women but not in older men.
Review
Endocrinology & Metabolism
L. Vandenput, H. Johansson, E. V. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -C. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -P. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, B. Schei, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, N. C. Harvey, M. Lorentzon, W. D. Leslie, J. A. Kanis
Summary: This study describes the collection of cohorts and the analysis plan for updating the fracture risk prediction tool FRAX. The aim is to optimize the current algorithms with respect to current and novel risk factors. The resource includes over 2 million participants and documented incident major osteoporotic fractures. The assembled cohorts and models will provide an updated FRAX tool for enhanced assessment of fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Audrey Bobillier, Philippe Wagner, Danielle E. Whittier, Rene Ecochard, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: The study found that poor vitamin D status and high parathyroid hormone levels are associated with the deterioration of bone microarchitecture and reduced bone strength in older men.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Francesca Bartoli-Leonard, Mandy E. Turner, Jonas Zimmer, Roland Chapurlat, Tan Pham, Masanori Aikawa, Aruna D. Pradhan, Pawel Szulc, Elena Aikawa
Summary: This study followed a group of elderly individuals for 8 years and found that elevated Lp(a) levels were associated with an increased risk of acute coronary syndrome. The study supports the recommendation of measuring Lp(a) levels in cardiovascular risk assessment.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Endocrinology & Metabolism
P. Chotiyarnwong, E. V. McCloskey, N. C. Harvey, M. Lorentzon, D. Prieto-Alhambra, B. Abrahamsen, J. D. Adachi, F. Borgstrom, O. Bruyere, J. J. Carey, P. Clark, C. Cooper, E. M. Curtis, E. Dennison, M. Diaz-Curiel, H. P. Dimai, D. Grigorie, M. Hiligsmann, P. Khashayar, E. M. Lewiecki, P. Lips, R. S. Lorenc, S. Ortolani, A. Papaioannou, S. Silverman, M. Sosa, P. Szulc, K. A. Ward, N. Yoshimura, J. A. Kanis
Summary: The IOF Epidemiology and Quality of Life Working Group report suggests that population screening for high hip fracture risk should be strongly considered in many healthcare systems to reduce the burden of fractures.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Dylan Girard, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In older men, higher hsCRP concentrations are associated with faster endocortical expansion and slightly higher cortical bone loss, but not with fracture risk. High hsCRP levels have limited impact on bone decline in older men.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexandre Mercier-Guery, Marjorie Millet, Blandine Merle, Corinne Collet, Flora Bagouet, Olivier Borel, Elisabeth Sornay-Rendu, Pawel Szulc, Emmanuelle Vignot, Deborah Gensburger, Elisabeth Fontanges, Martine Croset, Roland Chapurlat
Summary: miRNAs are potential prognostic markers in bone diseases, regulating gene expression as epigenetic factors. This study aims to identify circulating miRNAs associated with the severity of osteogenesis imperfecta (OI) and found a miRNA signature in OI patients. The study validates the expression of specific miRNAs in OI patients and explores the relationship between miRNA expression and clinical characteristics of OI. The findings suggest a potential role of miRNAs in regulating the physiopathology of OI.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Blandine Merle, Marie Cottard, Elisabeth Sornay-Rendu, Pawel Szulc, Roland Chapurlat
Summary: The study evaluates the prevalence of sarcopenia in spondyloarthritis (SpA) patients and its association with inflammation, disease activity, muscle performance, and quality of life. The results show that probable sarcopenia is significantly higher in SpA patients compared to controls. Probable sarcopenic SpA patients had higher inflammation and disease activity, impaired muscle performance, and lower quality of life. These findings suggest that muscle strength is an important aspect of SpA.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Meeting Abstract
Geriatrics & Gerontology
A. Mercier, M. Millet, B. Merle, O. Borel, E. Sornay-Rendu, P. Szulc, E. Vignot, D. Gensburger, E. Fontanges, M. Croset, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
P. Szulc, D. Whittier, K. Boyd, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
F. Benzema, B. Merle, E. Sornay-Rendu, A. Mercier, E. Vignot, P. Szulc, E. Lespessailles, R. Chapurlat
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Anne Piot, Ingrid Plotton, Stephanie Boutroy, Justine Bacchetta, Sylviane Ailloud, Herve Lejeune, Roland D. Chapurlat, Pawel Szulc, Cyrille B. Confavreux
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)