Article
Endocrinology & Metabolism
Lilian Sewing, Laura Potasso, Sandra Baumann, Denis Schenk, Furkan Gazozcu, Kurt Lippuner, Marius Kraenzlin, Philippe Zysset, Christian Meier
Summary: Type 1 diabetes (T1DM) is associated with an increased risk of nonvertebral fractures, and the influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM is not well understood. This study found that patients with long-standing T1DM had lower bone mineral density (BMD), decreased bone turnover, and weaker bones at the ultradistal tibia compared to non-diabetic controls. The presence of diabetic peripheral neuropathy was found to contribute to the altered cortical microarchitecture and reduced bone strength in T1DM patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Article
Pathology
Sonja Chen, Sara Gallant, Michael J. Cunningham, Caroline D. Robson, Alanna J. Church, Antonio R. Perez-Atayde, Alyaa Al-Ibraheemi
Summary: This study describes 8 cases of sinonasal myxoma (SNM) and analyzes the clinical and biological differences compared to desmoid fibromatosis. The findings expand the understanding of SNM and highlight its differences from desmoid fibromatosis in histology, clinical characteristics, and genetics.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Endocrinology & Metabolism
Nicola Hepp, Anja Lisbeth Frederiksen, Morten Duno, Niklas Rye Jorgensen, Jens-Erik Beck Jensen
Summary: HPP is a rare disease affecting bone mineralization, with adults having an increased occurrence of low-energy fractures and reduced physical performance compared to healthy controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Oncology
Anja Kafka, Anja Bukovac, Emilija Brglez, Ana-Marija Jarmek, Karolina Poljak, Petar Brlek, Kamelija Zarkovic, Niko Njiric, Nives Pecina-Slaus
Summary: This study investigated genetic and epigenetic changes as well as protein expression levels of negative regulators of Wnt signaling in human astrocytomas. The results emphasize the importance of methylation in Wnt signaling regulation, and suggest that large deletions of the APC gene and effects of beta-catenin and GSK3 beta play key roles in astrocytoma evolution. Further studies are needed to understand the clinical and therapeutic relevance of these molecular alterations.
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Endocrinology & Metabolism
Antonella Meloni, Laura Pistoia, Silvia Maffei, Paolo Ricchi, Tommaso Casini, Elisabetta Corigliano, Maria Caterina Putti, Liana Cuccia, Crocetta Argento, Vincenzo Positano, Alessia Pepe, Filippo Cademartiri, Cristina Vassalle
Summary: The purpose of this study was to investigate the relationship between hepatitis C virus (HCV) infection and bone mineral density (BMD), vitamin D, and bone turnover biomarkers in multi-transfused patients with thalassemia major (TM). The results showed that HCV infection was positively associated with the prevalence of low bone mass, suggesting that HCV infection is an additive risk factor for low bone mass in TM patients. Osteocalcin may play a role in this association.
Review
Biochemistry & Molecular Biology
Mutsuko Kukimoto-Niino, Mikako Shirouzu, Tesshi Yamada
Summary: TNIK is a promising therapeutic target for colorectal cancer due to its role in regulating the Wnt/β-catenin signaling pathway. In this study, structural insights into TNIK inhibitors targeting the ATP-binding site are presented.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jun Liu, Xinchang Deng, Xiao Liang, Longying Li
Summary: This study demonstrated that glabrene administration can effectively alleviate OVX-induced weight gain and increase in uterus weight, improve bone density and biomechanical parameters in OVX rats, and regulate the expression of various proteins in bone tissue, suggesting its potential as an alternative medicine for the prevention and treatment of postmenopausal osteoporosis through activation of the Wnt/beta-catenin signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Stale Nygard, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors have shown to be effective antitumor agents in specific tumor cell lines, with the ability to inhibit key signaling pathways and reduce expression of crucial oncogenes, ultimately impairing cell growth. Additionally, these inhibitors induce the accumulation of beta-catenin degradasomes containing TNKS1/2, which interact with YAP and angiomotin proteins, leading to attenuation of YAP signaling. Further research is needed to fully evaluate the potential of TNKS inhibitors in cancer treatment.
Article
Biochemistry & Molecular Biology
Kibrom M. Alula, Yaritza Delgado-Deida, Dakota N. Jackson, K. Venuprasad, Arianne L. Theiss
Summary: PHB1 plays a role in inhibiting the Wnt/β-catenin pathway to influence the development of intestinal tumorigenesis by regulating AXIN1 expression and the beta-catenin destruction complex. Induction of nuclear PHB1 trafficking provides a novel therapeutic option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestinal tumorigenesis.
Review
Cell Biology
Carlos Parra-Herran, W. Glenn McCluggage
Summary: Microcystic stromal tumour (MST) is a rare, usually benign, ovarian neoplasm with distinctive morphological features and characteristic immunohistochemical expression. It can also be associated with familial adenomatous polyposis.
Review
Cell Biology
Wibke Groenewald, Anders H. H. Lund, David Michael Gay
Summary: It is well known that mutations in the WNT-signalling pathway are significant in cancer development. Understanding the role and occurrence of these mutations within the pathway is crucial for developing effective therapeutic strategies. Some cancers have mutations at the receptor level of the pathway, while others have mutations in the cytoplasmic segment, leading to ligand-dependent or ligand-independent pathway activation, respectively. This review explores the driving mutations in cancer and the available therapeutic interventions for each type of mutation, and also discusses a potential new therapeutic avenue targeting the translational apparatus downstream from WNT signalling.
Letter
Gastroenterology & Hepatology
Diantha Terlouw, Frederik J. Hes, Manon Suerink, Arnoud Boot, Alexandra M. J. Langers, Carli M. Tops, Monique E. van Leerdam, Christi J. van Asperen, Steve G. Rozen, Emilia K. Bijlsma, Tom van Wezel, Hans Morreau, Maartje Nielsen
Article
Biochemistry & Molecular Biology
Syed Ahmed Shah, Muhammad Sohail, Marcel Karperien, Castro Johnbosco, Arshad Mahmood, Mubeen Kousar
Summary: Biopolymer-based thermoresponsive injectable hydrogels containing multifunctional characteristics show great potential for diabetic wound regeneration. In this study, Chitosan-CMC-g-PF127 injectable hydrogels loaded with Curcumin were developed, which exhibited viscoelastic behavior, good swelling properties, and a controlled release profile. The hydrogels demonstrated good biocompatibility and tissue regenerative ability, making them a promising platform for sustained drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Letter
Education, Scientific Disciplines
Elise V. van Wijk, Roemer J. Janse, Alexandra M. J. Langers
Article
Chemistry, Multidisciplinary
Tom Kamperman, Niels G. A. Willemen, Cindy Kelder, Michelle Koerselman, Malin Becker, Luanda Lins, Castro Johnbosco, Marcel Karperien, Jeroen Leijten
Summary: This study demonstrates that stimuli-responsive cell-adhesive micromaterials can self-assemble with cells into 3D living composite microtissues and provide control over the biomechanical and biochemical environment, influencing cell behavior.
Article
Engineering, Biomedical
Rong Wang, Xiaobin Huang, Bram Zoetebier, Pieter J. Dijkstra, Marcel Karperien
Summary: In this study, hydrogels with adjustable elasticity and degradation time were designed using the properties of hyaluronic acid and star shaped poly(ethylene glycol). The hydrogels showed biocompatibility and enhanced production of collagen type II, making them suitable as scaffolds for tissue regeneration applications.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Francesca Signori, Jos W. H. Wennink, Simona Bronco, Jan Feijen, Marcel Karperien, Ranieri Bizzarri, Pieter J. Dijkstra
Summary: Poly(lactide) (PLA) and poly(ethylene glycol) (PEG)-based hydrogels were prepared by mixing enantiomerically pure copolymers with opposite chirality. The gelation process was found to follow different mechanisms depending on the nature of the linker R. Mixing equimolar amounts of the enantiomeric copolymers resulted in micellar aggregates with a stereocomplexed PLA core and a hydrophilic PEG corona.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Nik Dekkers, Elham Zonoobi, Hao Dang, Mats I. I. Warmerdam, Stijn Crobach, Alexandra M. J. Langers, Jolein van der Kraan, Denise E. E. Hilling, Koen C. M. J. Peeters, Fabian A. A. Holman, Alexander L. L. Vahrmeijer, Cornelis F. M. Sier, James C. H. Hardwick, Jurjen J. J. Boonstra
Summary: This study aimed to select the most suitable imaging target for specific detection of high-grade dysplasia (HGD) and T1 colorectal cancer (T1CRC) from a panel of biomarkers. The results showed that CEA had the highest sensitivity and specificity in detecting HGD and T1 cancer foci in colorectal polyps.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Maurice C. E. van Dalen, Marcel Karperien, Mireille M. A. E. Claessens, Janine N. Post
Summary: The study investigates the use of amyloid fibril-based scaffolds to stimulate chondrocytes for the formation of articular cartilage. Different proteins were induced to self-assemble into amyloid fibrils and form micron scale amyloid networks resembling cartilage extracellular matrix. The results show that lysozyme amyloid micronetworks support chondrocyte viability and extracellular matrix deposition, while alpha-synuclein and beta-lactoglobulin only maintain cell viability.
Review
Engineering, Biomedical
Michelle Koerselman, Lisanne C. M. Morshuis, Marcel Karperien
Summary: This article discusses the application of small molecules such as peptides, aptamers, and variable antigen-binding domain of heavy chain only antibodies in tissue engineering and regenerative medicine. It compares these biological functionalities with conventional antibodies and provides an overview of recent work in this area. The article focuses on the structural differences, modifications, and conjugation strategies of these biologicals, as well as the clinical trials involving them. The challenges associated with each of these biologicals are also highlighted.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
D. Terlouw, A. Boot, Q. R. Ducarmon, S. Nooij, M. A. Jessurun, M. E. van Leerdam, C. M. Tops, A. M. J. Langers, H. Morreau, T. van Wezel, M. Nielsen
Summary: This study investigates colibactin-associated mutational signatures and suggests that colibactin may influence the development of colorectal neoplasms in predisposed patients.
GENES CHROMOSOMES & CANCER
(2023)
Article
Multidisciplinary Sciences
Elise V. van Wijk, Roemer J. Janse, Bastian N. Ruijter, Jos H. T. Rohling, Jolein van der Kraan, Stijn Crobach, Mario de Jonge, Arnout Jan de Beaufort, Friedo W. Dekker, Alexandra M. J. Langers
Summary: Multiple choice questions (MCQs) are reliable and easy to mark, but they can lead to cueing and recognition-based learning. Very short answer questions (VSAQs) provide an alternative by being open-ended and requiring short answers.
Article
Engineering, Biomedical
Nuno Araujo-Gomes, Barbara Zoetebier-Liszka, Bas van Loo, Malin Becker, Suzanne Nijhuis, Alexandra M. Smink, Bart J. de Haan, Paul de Vos, Marcel Karperien, Jeroen Leijten
Summary: Transplantation of microencapsulated pancreatic cells using monodisperse PEG-TA microgels is a promising therapy for T1DM. The microgels provide immunoprotection to transplanted cells and maintain their viability and function. These microencapsulated beta-cells are able to rapidly self-assemble into islet-sized spheroids, show limited immunogenicity, and remain glucose responsive both in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Castro Johnbosco, Lisanne Karbaat, Nicoline M. Korthagen, Kelly Warmink, Michelle Koerselman, Katja Coeleveld, Malin Becker, Bas van Loo, Bram Zoetebier, Sanne Both, Harrie Weinans, Marcel Karperien, Jeroen Leijten
Summary: This study investigates the effect of micromaterial composition and concentration on the therapeutic outcome of intra-articular injections of microencapsulated stem cells for the treatment of osteoarthritis. The results demonstrate that different polymer compositions and concentrations can significantly alter the metabolic activity and secretome of MSCs, as well as the retention time and biodistribution within the joint. Furthermore, the study shows that the different microgel formulations have a material-dependent effect on reducing cartilage degradation and matrix loss in rat joints with osteoarthritis.
MATERIALS TODAY BIO
(2023)
Article
Gastroenterology & Hepatology
Richard Hao H. Dang, Nik Dekkers, Ewout W. Steyerberg, Francisco Baldaque-Silva, Masami Omae, Krijn J. C. Haasnoot, Laurelle van Tilburg, Kate Nobbenhuis, Jolein van der Kraan, Alexandra M. J. Langers, Jeanin E. van Hooft, Wilmar de Graaf, Arjun D. Koch, Paul Didden, Leon M. G. Moons, James C. H. Hardwick, Jurjen J. Boonstra
Summary: This study aimed to evaluate existing and new prediction models for the duration of colorectal endoscopic submucosal dissection (ESD). The records of consecutive patients who underwent non-hybrid colorectal ESDs in three Dutch centers were reviewed. Prediction models were assessed and validated, providing useful tools for predicting ESD duration at Western centers.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Correction
Gastroenterology & Hepatology
Hao Dang, Nik Dekkers, Ewout W. Steyerberg, Francisco Baldaque-Silva, Masami Omae, Krijn J. C. Haasnoot, Laurelle van Tilburg, Kate Nobbenhuis, Jolein van der Kraan, Alexandra M. J. Langers, Jeanin E. van Hooft, Wilmar de Graaf, Arjun D. Koch, Paul Didden, Leon M. G. Moons, James C. H. Hardwick, Jurjen J. Boonstra
ENDOSCOPY INTERNATIONAL OPEN
(2023)