Article
Engineering, Biomedical
Saulo Martelli, Mario Giorgi, Enrico Dall'Ara, Egon Perilli
Summary: Analysis of microstructural deformation and fracture behavior of elderly femora revealed that cortical elastic instability promotes bone fracture behavior, enhancing load bearing capacity, toughness, and damage tolerance. These findings will contribute to the advancement of current methods for predicting hip fragility.
ACTA BIOMATERIALIA
(2021)
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: This study aimed to investigate the risk of major osteoporotic fractures in diabetes patients initiated with alendronate and denosumab. Results showed that the risk of incident major osteoporotic fractures among subjects with diabetes was similar between those initially treated with alendronate and denosumab, suggesting both treatments are equally effective in preventing osteoporotic fractures in subjects with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bijuan Qing, Nan Wang, Lingling Wang, Peng Li, Lishan Li, Hong Chen
Summary: This study evaluated the relationship between geriatric nutrition risk index (GNRI) and bone mineral density (BMD) in elderly Chinese individuals. Results showed that higher GNRI values were associated with higher total hip and lumbar spine T-scores, especially in women. GNRI may be a valuable indicator for identifying older individuals in need of further bone health nutritional support.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Medicine, General & Internal
Sug Hun Che, Myung-Rae Cho, Patrick Michael Quinn, Suk-Kyoon Song
Summary: This study aimed to identify risk factors for hip fractures in elderly Korean patients, especially in patients with osteoporosis. The retrospective analysis of 168 patients showed that lower body weight, BMI, and BMD Z-scores were associated with a higher incidence of intertrochanteric fractures compared to femoral neck fractures. This suggests that there is a correlation between low body weight, BMI, and BMD Z-scores and an increased risk of intertrochanteric fractures in elderly Korean patients.
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
James Webster, Darren C. C. Greenwood, Janet E. E. Cade
Summary: This study compared the risk of hip fracture between occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters in the UK Biobank. It was found that vegetarians had a higher risk of hip fracture, while occasional meat-eaters and pescatarians had a lower risk. BMI partially explained the observed risk difference.
Review
Endocrinology & Metabolism
Laila S. Tabatabai, Deborah E. Sellmeyer
Summary: Nutrition plays a crucial role in skeletal health, with calcium and vitamin D supplements showing potential in reducing fracture risk. However, data on the effects of other nutrient supplements are limited. The impact of nutrient interventions may be relatively small and further investigation is needed to determine potential benefits.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Medicine, General & Internal
Zhangxin Wen, Yongfang Li, Lulu Xu, Chun Yue, Qinyi Wang, Rong Chen, Na Ding, Xiaoli Qu, Yangna Ou, Yanyi Yang, Zhifeng Sheng, Hong Liu
Summary: This study revealed that TyG-BMI is associated with bone mineral density and risk of fracture in middle-aged and elderly Chinese individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Wenshuai Li, Houze Zhu, Junchuan Liu, Hongsen Tian, Jia Li, Linfeng Wang
Summary: This study measured VBQ scores using T1-weighted MRI images and compared them in patients with different previous fragility fracture times. Additionally, fracture patients had higher VBQ scores compared to age- and sex-matched non-fracture patients. The VBQ scores showed good predictive efficiency for fragility fractures.
EUROPEAN SPINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Xin-ping Li, Xiao-yu Li, Ming-hui Yang, Shi-wen Zhu, Xin-bao Wu, Ping Zhang
Summary: The study found that bone turnover markers peak 30-60 days after surgery, with P1NP showing less than 4 times elevation and CTX and OC rising less than 2 times. Females had higher levels of CTX and OC compared to males, and intertrochanteric fracture patients treated with intramedullary nailing had higher P1NP levels than femoral neck fracture patients undergoing hip replacement. 25(OH)D levels did not impact BTMs, and older patients aged 85 and above showed early decreases in OC levels during fracture healing.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Rheumatology
Saskia L. Wilson-Barnes, Susan A. -New, Helen Lambert
Summary: Osteoporosis is an ageing disorder characterized by poor bone microstructure and increased risk of fractures. Modifiable lifestyle factors such as diet, physical activity, and smoking status can optimize bone health and reduce fracture risk. Adequate intake of micronutrients and protein, along with maintaining an active lifestyle, are crucial. Other factors like alcohol intake and body composition can also be modified to reduce the risk of osteoporosis and fractures.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Review
Food Science & Technology
Emma O. Billington, Amita Mahajan, Jamie L. Benham, Maitreyi Raman
Summary: This systematic review examined the effects of probiotic interventions on bone health in postmenopausal women. The findings showed inconsistent effects of probiotics on bone mineral density and bone turnover markers. Further high-quality studies are needed to determine the role of probiotics in maintaining bone health in humans.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Yi Su, Suey S. Y. Yeung, Yu-Ming Chen, Jason C. S. Leung, Timothy C. Y. Kwok
Summary: This study found that the consumption of pro-inflammatory diets was associated with loss of muscle strength and physical function, as well as an increased risk of fractures in older Chinese men. Pro-inflammatory diets had no significant association with muscle-related outcomes but increased the long-term risk of osteoporosis in older Chinese women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)