Article
Endocrinology & Metabolism
Barbara Stachowska, Jowita Halupczok-Zyla, Justyna Kuliczkowska-Plaksej, Joanna Syrycka, Marek Bolanowski
Summary: Patients with active Cushing's syndrome show altered bone microstructure with decreased TBS, leading to a higher risk of hip and major osteoporotic fractures. TBS appears to be a valuable tool for assessing fracture risk in endogenous hypercortisolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Mitsuru Nishiyama, Yasumasa Iwasaki, Shinya Makino
Summary: This paper reviews recent studies on animal models of Cushing's syndrome, including features and complications induced by different glucocorticoid excess. Researchers found that administering exogenous corticosterone or implanting CORT pellets in mice successfully induced a Cushing's phenotype. They also developed other types of animal models to study the effects of corticotropin-releasing hormone overexpression and adrenal-specific Prkar1a deficiency on Cushing's syndrome, and designed transplantation methods for related medical treatments. In addition, this paper reviews the latest advances in using animal models to study glucocorticoid-induced complications.
Article
Endocrinology & Metabolism
Mario Detomas, Barbara Altieri, Wiebke Schlotelburg, Silke Appenzeller, Sven Schlaffer, Roland Coras, Andreas Schirbel, Vanessa Wild, Matthias Kroiss, Silviu Sbiera, Martin Fassnacht, Timo Deutschbein
Summary: The case presented a rare occurrence where a patient first had ACTH-independent CS and then developed CD. The successful treatment of CD after surgery and pathological examination indicated that different subtypes of Cushing's syndrome can develop in a single individual.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Aleksandra Radecka, Anna Lubkowska
Summary: In recent years, the usefulness of DXA in assessing adipose and lean tissue, bone mineral density, and fracture risk has been confirmed. DXA tests offer a quick and reliable analysis of body composition changes. The article discusses different DXA scans and their clinical significance in Cushing's syndrome.
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study found that lower levels of serum ucOC and cOC, as well as %cOC, were associated with less favorable metabolic parameters and a higher risk of MetS. Conversely, a lower proportion of ucOC was linked to better metabolic parameters and reduced risk of MetS. Further research is needed to determine if ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study demonstrated that lower levels of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS, while a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Chang Ho Ahn, Jung Hee Kim, Man Young Park, Sang Wan Kim
Summary: The study found that patients with Adrenal Cushing syndrome have multiple comorbidities even after treatment, requiring meticulous postoperative care.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Mysoon M. Al-Ansari, Eman A. Alnehmi, Abeer K. Malkawi, Ahmad Alodaib, Mohamed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: The study revealed distinct lipidomics profiles between LBMD and Ctrl groups, with 322 dysregulated lipid molecules identified, primarily in subclasses such as PC, TG, and PE. These findings offer insights into lipidomics alterations associated with bone remodeling and LBMD, potentially guiding the development of therapeutic targets and nutritional strategies for managing OP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mysoon M. Al-Ansari, Shereen M. Aleidi, Afshan Masood, Eman A. Alnehmi, Mai Abdel Jabar, Maha Almogren, Mohammed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: This study investigated sensitive and specific LBMD-associated protein biomarkers in patients diagnosed with ON and OP. The results identified distinctive proteomics profiles between the control, ON, and OP groups, as well as significant dysregulation in a panel of proteins common among the three groups. A comparison of proteins showed differences in their levels between ON and the control group, as well as between ON and OP. These findings provide potential protein biomarkers for further research on bone health and OP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Valentina Guarnotta, Francesca Di Gaudio, Carla Giordano
Summary: This study compared serum 25-hydroxyvitamin D (25(OH)D) levels in patients with Cushing's disease (CD) and controls, finding that CD patients had lower levels of vitamin D and that 25(OH)D levels were negatively correlated with urinary free cortisol. Cholecalciferol supplementation had a positive impact on insulin sensitivity and lipids.
Article
Endocrinology & Metabolism
Nina N. Sorensen, Christina M. Andreasen, Pia R. Jensen, Ellen M. Hauge, Jens Bollerslev, Jean-Marie Delaisse, Moustapha Kassem, Abbas Jafari, Marta Diaz-delCastillo, Thomas L. Andersen
Summary: This study found that increased cortisol production in patients with CS leads to increased bone marrow adiposity, primarily mediated by adipocyte hypertrophy. The differential pattern of adiposity in patients with CS and GC-O highlights that bone marrow adipocytes and their progenitors may respond differently in these two GC-mediated bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ming Zhou, Shiliang Han, Wenpeng Zhang, Dan Wu
Summary: This meta-analysis and systematic review suggests that vitamin K2 supplementation plays a significant role in maintaining and improving bone mineral density (BMD) in postmenopausal women with osteoporosis at a long-term follow-up. It also decreases the levels of undercarboxylated osteocalcin (uc-OC) and increases osteocalcin (OC) significantly. Vitamin K2 supplementation is beneficial and safe for the treatment of osteoporosis in postmenopausal women.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Plant Sciences
Haesu Lee, Mi Hye Kim, La Yoon Choi, Woong Mo Yang
Summary: This study investigated the role and mechanism of Osteo-F herbal formula in bone formation in osteoporosis, showing that Osteo-F ameliorated bone loss by increasing bone forming molecules including BMP-2 and OPN. Osteo-F may be an alternative material for managing osteoporosis with bone anabolic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang
Summary: The study updated BMD T-score references using the most recent NHANES data, finding significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing guidelines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Aida Orois, Eva Lopez-Quesada, Gloria Jalencas, Maria-Jose Barahona, Veronica Perea
Summary: The effectiveness of universal screening for thyroid disease in pregnancy remains controversial.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, Research & Experimental
Dermot O'Toole, Pamela L. Kunz, Susan M. Webb, Grace Goldstein, Sheila Khawaja, Mark McDonnell, Sandra Boiziau, Delphine Gueguen, Aude Houchard, Antonio Ribeiro-Oliveira, Ally Prebtani
Summary: In patients with neuroendocrine tumors or acromegaly treated with long-acting somatostatin analogs, LAN demonstrated reduced injection-site pain and technical problems compared to OCT.
ADVANCES IN THERAPY
(2023)
Article
Endocrinology & Metabolism
Alicia Santos, Chiara Nalin, GianMario Bortolotti, Elisabet Dominguez-Clave, Gianola Daniela, Liana Cortesi, Marina Pagani, Maria A. M. Momblan, Ignasi Gich, Susan M. Webb, Roberto Trevisan, Eugenia Resmini
Summary: This study demonstrates the value of a mindfulness program in patients with acromegaly, showing improvements in sleep, reduction in pain, and increased self-compassion.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Carmen Quiroes, Nuria Alonso-Carril, Silvia Rodriguez-Rodriguez, Maria-Jose Barahona, Aida Orois, Andreu Simoe-Servat, Montserrat Ramos, Veronica Perea
Summary: Improvements in continuous glucose monitoring have revolutionized the treatment of type 1 diabetes, and the Medtronic 780G system has been shown to achieve and maintain good glycemic control over a 6-month period in real-life conditions.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria Arnoriaga-Rodriguez, Yenny Leal, Jordi Mayneris-Perxachs, Vicente Perez-Brocal, Andres Moya, Wifredo Ricart, Merce Fernandez-Balsells, Jose Manuel Fernandez-Real
Summary: Sleep disruption is associated with worse glucose metabolic control and altered gut microbiota. This study found an association between rapid eye movement (REM) sleep duration and glucose levels as well as gut microbiota composition. Sleep deprivation can lead to poor glucose control and microbiota imbalance, negatively impacting metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagstrom, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Laine, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stal, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
Summary: Hyperferritinaemia is often associated with metabolic dysfunction and fatty liver and is linked to an increased risk of cardiometabolic and liver diseases. The main determinants of ferritin levels in individuals with metabolic dysfunction are genetic variants that affect iron metabolism. However, there is currently a lack of validated criteria for the diagnosis and staging of metabolic hyperferritinaemia, and the benefits of iron depletion therapy remain unclear. In this article, the authors provide an overview of the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction and propose updated definitions and staging systems, highlighting research gaps and suggesting future study designs and outcome measures.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Marisel Rosell-Diaz, Jose Manuel Fernandez-Real
Summary: The decline in cognitive function and the prevalence of neurodegenerative disorders are serious threats to health in old age, with dementia affecting 50 million people worldwide. Type 2 diabetes is linked to an increased risk of cognitive impairment and dementia. Studies have shown that metformin, a medication used to treat type 2 diabetes, may partially restore gut dysbiosis related to diabetes and potentially improve cognitive function.
Article
Biochemistry & Molecular Biology
Nicolas M. Suarez, Shifa Jebari-Benslaiman, Roberto Jimenez-Monzon, Asier Benito-Vicente, Yeray Brito-Casillas, Laida Garces, Ana M. Gonzalez-Lleo, Antonio Tugores, Mauro Boronat, Cesar Martin, Ana M. Wagner, Rosa M. Sanchez-Hernandez
Summary: The p.(Tyr400_Phe402del) mutation in the LDL receptor (LDLR) gene is the most common cause of familial hypercholesterolaemia (FH) in Gran Canaria. The age and origin of this prevalent founder mutation were determined, and its functional consequences were explored. Haplotype analysis revealed that the mutation originated from a common ancestral haplotype approximately 387 (110-1572) years ago, after the Spanish colonization of the Canary Islands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Milton Fabian Suarez-Ortegon, Jenny Elizabeth Ordonez-Betancourth, Jose Guillermo Ortega-Avila, Ana Yibby Forero, Jose Manuel Fernandez-Real
Summary: This study evaluated the relationship between three adiposity markers and iron-deficient status in reproductive-age women. The results showed that waist circumference, waist-to-height ratio, and BMI were inversely associated with iron deficiency. Among them, waist-to-height ratio had the strongest correlation.
Article
Nutrition & Dietetics
Yeray Novoa-Medina, Marta Barreiro-Bautista, Marta Perdomo-Quinteiro, Jesus Maria Gonzalez-Martin, Sofia Quinteiro-Gonzalez, Angela Dominguez, Maria Cabrera, Sara Lopez, Svetlana Pavlovic, Ana M. M. Wagner
Summary: This study investigated Vitamin D levels in children with type 1 diabetes in the Canary Islands, finding higher levels in the summer and autumn months. There was an inverse correlation between the occurrence of diabetes and age. Despite being located in a subtropical region, Vitamin D deficiency is common among children in this area. However, after adjusting for acidosis, there were no differences in Vitamin D levels between diabetic and non-diabetic children.