Article
Endocrinology & Metabolism
Sofia Ish-Shalom, Yoseph Caraco, Nariman Saba Khazen, Michal Gershinsky, Auryan Szalat, Phillip Schwartz, Ehud Arbit, Hillel Galitzer, Jonathan C. Y. Tang, Gregory Burshtein, Ariel Rothner, Arthur Raskin, Miriam Blum, William D. Fraser
Summary: Oral hPTH(1-34) treatment as an adjunct to standard therapy in adult patients with hypoparathyroidism was found to be safe and effective, allowing for a reduction in exogenous calcium supplementation while maintaining normocalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Narisaku Inada, Tetsuya Ohata, Hideto Maruno, Takeshi Morii, Naobumi Hosogane, Shoichi Ichimura
Summary: This study aimed to determine the optimal timing of PTH (1-34) administration in a rabbit distraction osteogenesis model. The results showed that PTH (1-34) administration during the consolidation phase led to the best outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Orthopedics
Ashley R. Sweeney-Ambros, Amy E. Biggs, Nicholas D. Zimmerman, Kenneth A. Mann, Timothy A. Damron, Megan E. Oest
Summary: Post-radiotherapy bone fragility fractures are a common complication in cancer survivors. This study investigated the effects of combined delivery of parathyroid hormone and zoledronic acid on post-radiotherapy bone health and explored the potential use of parathyroid hormone as a bone marrow radioprotectant.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Eliane H. Dutra, Mara H. O'Brien, Po-Jung Chen, Mei Wei, Sumit Yadav
Summary: I-PTH administration leads to increased bone volume, tissue density, mineral deposition, osteoclastic activity, cell proliferation, and cartilage thickness in the mandibular condylar cartilage (MCC). Additionally, I-PTH administration results in an increase in expression of vascular endothelial growth factor and a decrease in expression of sclerostin, matrix metallopeptidase 13, and aggreganase-1 (ADAM-TS4) in the cartilage. Molecular analysis shows decreased expression of collagen type X (Col10a1), alkaline phosphatase (Alp), and Indian Hedgehog (Ihh), and increased expression of Sox9, fibroblast growth factor 2 (Fgf2), and proteoglycan 4 (Prg4) in I-PTH-treated chondrocytes.
Article
Engineering, Biomedical
Zhiyuan Zou, Le Wang, Zhifei Zhou, Qing Sun, Delong Liu, Yan Chen, Hao Hu, Yu Cai, Sixiong Lin, Zhengran Yu, Bizhi Tan, Wei Guo, Zemin Ling, Xuenong Zou
Summary: The use of hydrogels containing PTH and nHAP can promote cranial bone regeneration by enhancing the expression of osteogenic-related proteins and facilitating osteogenic differentiation of BMSCs through the Notch signaling pathway. Implantation of the hydrogel into a rat cranial defect model showed efficient bone regeneration compared to using the hydrogel alone or nHAP alone, indicating a promising therapeutic effect of combining nHAP and PTH for bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Tiancheng Li, Han Wang, Chunxiao Lv, Li Huang, Cheng Zhang, Chenchen Zhou, Shujuan Zou, Peipei Duan
Summary: Intermittent PTH promotes periodontal repair by accelerating the regeneration of root resorption through ephrinB2-EPHB4 forward signaling pathway, as evidenced by in vivo and in vitro experiments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Han Xia, Yueyang Tian, Yile Lin, Qia Huang, Yuan Xue
Summary: This study found that Insulin-like growth factor-binding protein 7 (IGFBP7) plays an important role in mediating the anabolic effects of parathyroid hormone (PTH). Intermittent PTH administration increased the expression of IGFBP7 in mesenchymal stem cells (MSCs) and pre-osteoblasts. Knockdown of IGFBP7 interrupted the anabolic effects of PTH, while supplementation with IGFBP7 protein enhanced the bone-forming efficacy of PTH. In a mouse model of fracture, administration of IGFBP7 along with PTH accelerated bone healing.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rene St-Arnaud, Martin Pellicelli, Mahmoud Ismail, Alice Arabian, Toghrul Jafarov, Chengji J. Zhou
Summary: PTH induces phosphorylation of NACA and LRP6, leading to their nuclear translocation and expression of the target gene Lrp6. Knockout of Naca and Lrp6 in mice abolishes the anabolic response to iPTH, indicating that NACA and LRP6 play important roles in ensuring maximal response to iPTH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ye Cheng, Fan Li, Xiaoyue Xiao, Shujuan Zou, Jianwei Chen
Summary: Intermittent parathyroid hormone administration promotes cementoblast-mediated cementogenesis during periodontal repair in a time-dependent manner.
Article
Biotechnology & Applied Microbiology
Tiancheng Li, Han Wang, Kai Xia, Zuping Wu, Ruojing Liu, Xing Yin, Chenchen Zhou, Yuyu Li, Shujuan Zou
Summary: This study identified differential expression of 190 lncRNAs and 135 mRNAs during intermittent PTH-induced cementogenesis, with eight lncRNAs identified as possible core regulators of the negatively regulated Wnt signaling pathway. The study further verified the repressed expression of key components of the Wnt signaling pathway, suggesting that lncRNAs may play important roles in PTH-induced cementogenesis through Wnt pathway regulation.
Article
Endocrinology & Metabolism
Kelly L. Roszko, Tiffany Y. Hu, Lori C. Guthrie, Beth A. Brillante, Michaele Smith, Michael T. Collins, Rachel Gafni
Summary: Patients with hypoparathyroidism experience poor quality of life, including fatigue and brain fog. Treatment with PTH 1-34 had limited and non-sustained effects on improving quality of life, inconclusive changes in fatigue experience, and no change in the 6-minute walk test.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Orthopedics
Tetsutaro Abe, Masashi Miyazaki, Toshinobu Ishihara, Shozo Kanezaki, Yuhta Tsubouchi, Hiroshi Tsumura
Summary: The study investigated the optimal administration method for the combination of BMP-2 and PTH 1-34 in a rat spinal fusion model. Results showed that frequent administration of PTH may lead to thicker and stronger trabecular bone structure in newly formed bone when BMP-2 is insufficient.
Article
Cell & Tissue Engineering
C-H Chen, L. Kang, L-H Chang, T-L Cheng, S-Y Lin, S-C Wu, Y-S Lin, S-C Chuang, T-C Lee, J-K Chang, M-L Ho
Summary: Intra-articular injections of PTH in guinea pigs improved endurance, preserved glycosaminoglycans, and reduced OA symptoms, suggesting a potential therapeutic effect on age-related OA.
BONE & JOINT RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Zohaib Khurshid, Faris Yahya Asiri
Summary: The review summarized the effects of PTH on periodontal tissues during orthodontic tooth movement. While most studies suggest a favorable outcome, there are also multiple sources of bias present.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Dan Wang, Yimeng Du, Wenpeng Zhang, Xiaolu Han, Hui Zhang, Zengming Wang, Nan Liu, Meng Li, Xiang Gao, Xiaomei Zhuang, Jing Gao, Aiping Zheng
Summary: Efforts were made to develop an effective and biosafe intranasal formulation for parathyroid hormone (1-34), with 10% Kolliphor(R) HS.15 identified as a permeation enhancer that significantly increased the bioavailability of PTH(1-34). Further research on intranasal formulations with higher concentrations of Kolliphor(R) HS.15 for enhanced bioavailability of PTH(1-34) could be considered.
