Article
Endocrinology & Metabolism
Ali Ghasem-Zadeh, Minh Bui, Ego Seeman, Steven K. Boyd, Sandra Iuliano, Rizwan Jaipurwala, Peter F. Mount, Nigel D. Toussaint, Cherie Chiang
Summary: Patients with chronic kidney disease (CKD) may experience reduced estimated failure load due to deterioration in bone microarchitecture, regardless of their femoral neck (FN) bone mineral density (BMD) status. This suggests that bone fragility could be present in CKD patients despite osteopenia or normal BMD, highlighting the importance of measuring microarchitecture in assessing fracture risk and targeting therapy effectively.
Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Robert Wakolbinger-Habel, Matthias Reinweber, Juergen Koenig, Rochus Pokan, Daniel Koenig, Peter Pietschmann, Christian Muschitz
Summary: The study found that the bone microarchitecture of vegans differed from omnivores, but this difference could not be solely attributed to nutrient intake. However, the differences in bone structure were attenuated in those who engaged in resistance training, regardless of their dietary choices.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Fjola Johannesdottir, Melissa S. Putman, Sherri-Ann M. Burnett-Bowie, Joel S. Finkelstein, Elaine W. Yu, Mary L. Bouxsein
Summary: The study found that postmenopausal Black women have similar rates of bone loss compared to White women, with lower weight women experiencing greater declines in bone density and microstructure at the radius. Women who lost weight during the follow-up period had higher rates of bone loss, particularly at the tibia, while higher baseline total body fat mass was protective against bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Wenmin Guan, Qianqian Pang, Chenxi Jin, Yiyi Gong, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Yan Jiang, Weibo Xia
Summary: X-linked hypophosphatemia (XLH) patients have abnormal lumbar spine bone mass, but compromised microarchitecture and bone strength in the peripheral bone.
Article
Orthopedics
Carsten Schlickewei, Conradin Schweizer, Klaus Pueschel, Benjamin Ondruschka, Holger Kleinertz, Alexej Barg, Tim Rolvien, Julian Stuerznickel
Summary: This study examines the effects of age, sex, and subregion on the bone microarchitecture and strength of the distal fibula. Results show that cortical parameters increase and trabecular parameters decrease from distal to proximal. Age is primarily associated with a cortical decrease in all subregions for women, while men also exhibit age-associated decreases in certain parameters. The stiffness and failure load are highest in the type C subregion for both genders. A critical age-related decline in bone strength parameters is observed in the type B subregion for women, providing an explanation for the increased incidence of low-traumatic type B fractures in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
E. H. S. Koy, A. Amouzougan, E. Biver, R. Chapurlat, T. Chevalley, S. L. Ferrari, A. Fouilloux, H. Locrelle, H. Marotte, M. Normand, R. Rizzoli, L. Vico, T. Thomas
Summary: This study presents reference values of HR-pQCT measurements in a Franco-Swiss female cohort at the distal radius and tibia sites, considering specific age bounds. Microarchitectural parameters start to decline before the age of 30, with the optimal bone profile observed between the ages of 22 to 27 in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Luis Fernando Escobar Guzman, Neuza Helena Moreira Lopes, Georgea H. Fernandes Torres, Liliam Takayama, Solange de Sousa Andrade, Jose Ramon Lanz-Luces, Rosa Maria R. Pereira, Carlos Eduardo Rochitte
Summary: Epidemiological studies have shown a correlation between osteoporosis and the risk of ischemic cardiovascular disease. In this study based on the SPAH study, researchers found an association between coronary calcification and bone microarchitecture in older adults. The results suggest an inverse relationship between CAC and cortical bone content, as assessed by HR-pQCT, with higher coronary calcification in individuals older than 65 years.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Nicklas Hojgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrom Jensen, Peter Vestergaard
Summary: This study compared the bone mineral density, bone strength, and bone microarchitecture of individuals with type 1 diabetes and type 2 diabetes to those without diabetes. The results showed that individuals with type 1 diabetes had lower bone density, while those with type 2 diabetes had higher bone density. Both groups showed favorable bone microarchitecture and strength parameters at the tibia and radius.
Article
Endocrinology & Metabolism
Ko Chiba, Naoki Iwamoto, Kounosuke Watanabe, Kazuteru Shiraishi, Kengo Saito, Naoki Okubo, Atsushi Kawakami, Makoto Osaki
Summary: This study investigated the effect of denosumab on bone mineral density (BMD) and bone microarchitecture in patients with rheumatoid arthritis (RA) treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). The results suggest that denosumab can increase BMD and improve bone microarchitecture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Endocrinology & Metabolism
Constantin Schmidt, Julian Stuerznickel, Andre Strahl, Ralf Oheim, Christina Weiler-Normann, Marcial Sebode, Florian Barvencik, Ansgar W. Lohse, Thorsten Schinke, Michael Amling, Christoph Schramm, Tim Rolvien
Summary: In patients with autoimmune hepatitis, there is a significant age-dependent deterioration of cortical bone microarchitecture, which may contribute to the increased fracture risk observed in these patients. Specifically, these patients showed a predominant reduction in cortical thickness at the distal radius and tibia, with no significant differences in trabecular parameters.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Editorial Material
Transplantation
Rajiv Agarwal, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Pierre Gabai, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Maelys Granal, Denis Fouque, Micher Ducher, Jean-Pierre Fauvel
Summary: This study used artificial intelligence to define the relationship between kalemia, dietary potassium intake, and renal function in chronic kidney disease (CKD) patients. The results showed that strict dietary potassium control is not necessary to regulate kalemia in CKD1-4 patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Dylan Girard, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In older men, higher hsCRP concentrations are associated with faster endocortical expansion and slightly higher cortical bone loss, but not with fracture risk. High hsCRP levels have limited impact on bone decline in older men.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Vincenzo Bellizzi, Giorgina B. Piccoli, Yunying Shi, Soo Kun Lim, Sumira Riaz, Rocio Urbina Arronte, Wai Pooi Lau, Denis Fouque
Summary: An expert advisory board discussed the prevention and treatment of CKD, with a focus on dietary options. The timing of dialysis start is influenced by patients' clinical status and patient-clinician interactions. Therapies that preserve kidney function, such as adjusting lifestyle and diet, can prolong the dialysis-free period and improve CKD management.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Engineering, Biomedical
Ahmet Sen, Helene Follet, Elisabeth Sornay-Rendu, Yves Remond, Daniel George
Summary: This article proposes a theoretical numerical model to predict patient dependent osteoporotic bone degradation. The model parameters are identified through a particle swarm optimization algorithm and based on individual patient high resolution peripherical quantitative computer tomography (HRpQCT) scan data. The degradation model is based on cellular activity initiated by the elastic strain energy developed in the bone microstructure through patient's body weight. The macro and meso scale analyses are carried out and compared with in-vivo experimental bone degradation for four elderly women over a period of 10 years, showing a significant correlation and low average deviation error. The model can be easily extended to other patients and provide accurate predictions for different population categories.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Letter
Nutrition & Dietetics
David E. St-Jules, Denis Fouque
Summary: Diet therapy for hyperkalemia in people with chronic kidney disease has changed due to weak or no correlation between reported potassium intake and plasma potassium levels. The risk of postprandial hyperkalemia from high-potassium plant foods remains a debated topic. Although additional research is needed, some argue that the available research supports that high-potassium plant foods are not a risk for postprandial hyperkalemia. This editorial critiques the analyses offered and advocates for a cautious approach to care.
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexandre Mercier-Guery, Marjorie Millet, Blandine Merle, Corinne Collet, Flora Bagouet, Olivier Borel, Elisabeth Sornay-Rendu, Pawel Szulc, Emmanuelle Vignot, Deborah Gensburger, Elisabeth Fontanges, Martine Croset, Roland Chapurlat
Summary: miRNAs are potential prognostic markers in bone diseases, regulating gene expression as epigenetic factors. This study aims to identify circulating miRNAs associated with the severity of osteogenesis imperfecta (OI) and found a miRNA signature in OI patients. The study validates the expression of specific miRNAs in OI patients and explores the relationship between miRNA expression and clinical characteristics of OI. The findings suggest a potential role of miRNAs in regulating the physiopathology of OI.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Blandine Merle, Marie Cottard, Elisabeth Sornay-Rendu, Pawel Szulc, Roland Chapurlat
Summary: The study evaluates the prevalence of sarcopenia in spondyloarthritis (SpA) patients and its association with inflammation, disease activity, muscle performance, and quality of life. The results show that probable sarcopenia is significantly higher in SpA patients compared to controls. Probable sarcopenic SpA patients had higher inflammation and disease activity, impaired muscle performance, and lower quality of life. These findings suggest that muscle strength is an important aspect of SpA.
CALCIFIED TISSUE INTERNATIONAL
(2023)