Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Review
Medicine, General & Internal
Maohui Diao, Jun Peng, Daidong Wang, Hongbo Wang
Summary: This study conducted a systematic review and meta-analysis to explore the influence of vitamin D on ankylosing spondylitis (AS). The results showed that patients with AS had lower levels of peripheral 25-hydroxyvitamin D (25OHD) and higher levels of peripheral C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). This suggests that vitamin D may have a protective effect on AS, and CRP and ESR serve as important biomarkers for AS.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Leila J. Mady, Yan Zhong, Puneet Dhawan, Sylvia Christakos
Summary: In this study, CARM1 was identified as a significant coactivator of 1,25(OH)(2)D-3, mediating the transcription of Cyp24a1 and acting as a repressor of CYP27B1. These findings highlight the key role of CARM1 in the regulation of 1,25(OH)(2)D-3's biological function.
Review
Biochemistry & Molecular Biology
Simona Fenizia, Melania Gaggini, Cristina Vassalle
Summary: This review discusses the interaction between vitamin D and sphingolipids, with a focus on cardiometabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Miaomiao Zhao, Zhenhua Liu, Hongtai Shi, Jianxiang Song
Summary: The prognostic value of vitamin D receptor (VDR) in various digestive system tumors is still controversial. This meta-analysis found that high VDR expression is generally associated with better overall survival (OS) in digestive system tumors, but the association is not significant in colorectal cancer. VDR expression can serve as a prognostic indicator and a reference for vitamin D supplementation, helping to evaluate prognosis and formulate precise treatment plans for patients with digestive system tumors.
Article
Biochemistry & Molecular Biology
Aleksandra Marchwicka, Kuba Nowak, Anastasiia Satyr, Dariusz Wolowiec, Ewa Marcinkowska
Summary: Hematological malignancies are characterized by uncontrolled proliferation and differentiation block of blood cells, leading to loss of function. 1,25-dihydroxyvitamin D has been proposed as a potential therapy to stimulate the immune system and inhibit proliferation of leukemic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nipith Charoenngam
Summary: Vitamin D plays a crucial role in maintaining skeletal and immune health, and research has shown an association between vitamin D levels and rheumatic diseases. However, the specific benefits of vitamin D supplements for treating and preventing rheumatic diseases are still debated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Xiaoyi Zhang, Li Zhang, Yingzhen Wen, Mengxian Zhang, Shuangxin Liu, Houqin Xiao
Summary: This study investigated the protective effect and potential mechanism of vitamin D on podocyte injury in diabetic kidney disease (DKD). The results showed that treatment with a vitamin D analogue significantly reduced albuminuria and improved renal pathology in diabetic mice. Furthermore, vitamin D enhanced podocyte autophagy activity, restored the expression of slit diaphragm proteins, and inhibited podocyte apoptosis under diabetic conditions.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tiphaine Raia-Barjat, Camille Sarkis, Florence Rancon, Lise Thibaudin, Jean-Christophe Gris, Nadia Alfaidy, Celine Chauleur
Summary: Maternal vitamin D insufficiency during pregnancy may increase the risk of preeclampsia, and lower vitamin D levels at 32 weeks are associated with a higher risk of placenta-mediated complications. Maintaining adequate levels of vitamin D in pregnant women can help prevent the onset of late PMC.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Oleg Tsuprykov, Saban Elitok, Claudia Buse, Chang Chu, Bernhard Karl Kraemer, Berthold Hocher
Summary: This study compared the correlation of different vitamin D compounds in pregnant women, finding that total 1,25(OH)(2)D showed the best correlation with various health markers. Free 25(OH)D and bioavailable 25(OH)D are more precise indicators of vitamin D status than total 25(OH)D.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Sunny Malhotra, Luciana Midaglia, Omar Chuquisana, Nikolaos A. A. Patsopoulos, Roser Ferrer, Marina Giralt, Nicolas Fissolo, Elia Gil-Varea, Juan Carlos Trivino, Jan D. D. Luenemann, Xavier Montalban, Manuel Comabella
Summary: This study found an association between the CYP24A1 rs2762943 polymorphism and increased risk of multiple sclerosis (MS). Carriers of this risk allele had lower levels of active vitamin D and higher levels of inflammatory factors. However, this genetic variant had no significant impact on disease activity and disability outcomes of MS patients, only with a younger age at disease onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Adam Maciejewski, Katarzyna Lacka
Summary: Vitamin D plays a crucial role in immunity and differentiation/proliferation processes, and it is potentially associated with thyroid cancer. This study systematically reviewed publications on the association between vitamin D-related gene variants and thyroid cancer. Results were inconclusive, and further validation is required.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Lailiang Wang, Qun Luo, Fangfang Zhou, Beixia Zhu
Summary: This study investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and brachial-ankle pulse wave velocity (baPWV) as well as mortality among peritoneal dialysis (PD) patients. Results showed that serum 25(OH)D concentration was negatively associated with baPWV, and lower 25(OH)D levels were significantly related to higher total mortality in PD patients. Additional studies with larger sample sizes are needed to confirm these findings.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Marchwicka, Urszula Nowak, Anna Grembowska, Agnieszka Jakuszak, Piotr Poreba, Ewa Marcinkowska
Summary: It has been found that fibroblast growth factor receptors play a crucial role in regulating the vitamin D receptor gene and cell differentiation. Overexpression of fibroblast growth factor receptors in myeloid leukemia cells upregulates the expression of the vitamin D receptor gene and promotes cell differentiation, while it has no effect on the expression and activity of the vitamin D receptor gene in bone cells.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoying Cui, John J. McGrath, Thomas H. J. Burne, Darryl W. Eyles
Summary: Numerous epidemiological studies have linked vitamin D deficiency with schizophrenia, particularly in newborns. Research suggests that early-life vitamin D deficiency may increase the risk of developing schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
