Review
Biochemistry & Molecular Biology
Lukasz Obolonczyk, Izabela Karwacka, Piotr Wisniewski, Krzysztof Sworczak, Tomasz Oseka
Summary: This study presents the experience with 143 cases of P-FNAB with iPTH-WC assessment and compares it with other imaging techniques. The results show that P-FNAB with iPTH-WC is a highly sensitive method for localizing parathyroid adenoma during PHPT, surpassing the sensitivity of Tc99-MIBI. Furthermore, P-FNAB has mild complications and can be considered a safe procedure.
Article
Chemistry, Multidisciplinary
Yi Wang, Yingkun Hu, Shenghui Lan, Zhe Chen, Yufeng Zhang, Xiaodong Guo, Lin Cai, Jingfen Li
Summary: The local application of drug-loaded bioactive scaffold materials shows potential for solving OP bone defects. This study successfully loaded polydopamine nanoparticles and PTHrP-1 onto natural 3D bioactive scaffolds. The scaffolds were found to affect ossification, osteoclastogenesis, and macrophage polarization, and were able to regulate osteoclastic activity and new bone formation in vitro. Furthermore, the potential of these scaffolds to promote the repair of OP bone defects was verified in small animal studies. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.
Article
Engineering, Multidisciplinary
Yi Wang, Zhuowen Hao, Yufeng Zhang, Yingkun Hu, Tianhong Chen, Feifei Yan, Minhao Wu, Chong Zhang, Renxin Chen, Beihai Li, Xinxin Wu, Hanke Li, Qixin Zheng, Xiaodong Guo, Guohui Liu, Zhenwei Zou, Jingfeng Li, Lin Cai
Summary: Bone regeneration requires the interaction of multiple factors, including osteogenesis, osteolysis, angiogenesis, and an appropriate immune microenvironment. Recombinant human parathyroid hormone (PTH1-34) has been proven effective for clinical treatment of osteoporosis. However, its use in local bone repair is limited due to net bone resorption. This study proposes a strategy using multifunctional calcium phosphate (CaP) ceramics to modulate the effects of M1 macrophages and promote bone regeneration. The functionalization of the CaP ceramic scaffold with parathyroid hormone related peptide-1 (PTHrP-1) improves the osteogenic microenvironment, retains osteogenic and angiogenic properties, and achieves slow release of PTHrP-1. The results show that PTHrP-1-TBC is more suitable for bone regeneration than the unmodified peptide or the TBC scaffold alone.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Endocrinology & Metabolism
Sondra O'Callaghan, Hanford Yau
Summary: Cinacalcet, an orally taken agent, has the potential to effectively reduce symptoms associated with malignancy-associated hypercalcemia and maintain normal serum calcium levels, impacting morbidity and potentially increasing survival rates. Further studies are needed to explore its efficacy in normalizing calcium levels, improving quality of life, and influencing survival in MAH patients.
ENDOCRINE CONNECTIONS
(2021)
Article
Endocrinology & Metabolism
Natalia G. Mokrysheva, Anna K. Eremkina, Alina R. Elfimova, Elena V. Kovaleva, Anastasiia P. Miliutina, Ekaterina E. Bibik, Anna M. Gorbacheva, Ekaterina A. Dobreva, Irina S. Maganeva, Julia A. Krupinova, Rustam H. Salimkhanov, Lizaveta A. Aboishava, Elena V. Karaseva, Galina A. Melnichenko, Ivan I. Dedov
Summary: The aim of this study was to estimate the clinical and biochemical profile, complications, surgical intervention, and medical therapy of patients with primary hyperparathyroidism (PHPT) in the Russian Federation. The results showed that the detection rate of PHPT has increased in recent years, but most patients still had significant alterations in phosphorus-calcium metabolism, indicating delayed diagnosis and the need for further improvement in medical care.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna Zenno, Bhavishya Ramamoorthy, Dima A. Hammoud, Martha Quezado, Martha A. Zeiger, Smita Jha
Summary: We present a case of a 9-year-old girl with symptomatic hypercalcemia from primary hyperparathyroidism (PHPT). The patient had persistent hyperparathyroidism after initial surgical intervention, but a successful redo parathyroidectomy cured her condition. We also review common locations for ectopic parathyroid adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Banafsheh Safari, Soodabeh Davaran, Ayuob Aghanejad
Summary: Bone tissue engineering aims to create bio-inspired systems with a coordinated combination of cells, scaffolds, and bioactive factors to repair damaged bone tissue. Bioactive factors such as cytokines, growth factors, peptides, and hormonal signals play a significant role in stimulating osteogenic differentiation and proliferation of cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Shun-Ping Wang, Ying-Ju Chen, Cheng-En Hsu, Yung-Cheng Chiu, Ming-Tzu Tsai, Jui-Ting Hsu
Summary: Intermittent parathyroid hormone (PTH) has a positive effect on bone mineral density of the femoral neck in ovariectomized rats, and the ability of the femoral neck to resist fracture is correlated with its bone structural parameters.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Cell Biology
Liting Wang, Rining Tang, Yuxia Zhang, Sijie Chen, Yu Guo, Xiaochen Wang, Zixiao Liu, Hong Liu, Xiaoliang Zhang, Bi-Cheng Liu
Summary: The study revealed that PTH induces valvular EndMT in VC through the miR-29a-5p/GSAP/Notch1 pathway, which may contribute to VC in CKD rats.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Hadla Hariri, Rene St-Arnaud
Summary: This review highlights recent research on the regulatory functions of ubiquitin-specific peptidases (USPs) in osteoblasts and provides insight into the molecular mechanisms governing their actions. It also discusses the role of USP53 in osteoblasts and the complex layers of regulation exerted by USPs on osteoblast signaling. Further studies using knockout mouse models are necessary for a full understanding of the mechanisms underpinning USPs actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Huazhen Liu, Dan Gao, Yongfa Huang, Ji Li, Mengyun Zhao, Zhaohui Lu, Ya Hu, Tao Wang, Yingqiang Zhang, Wenze Wang, Dongyan Cao
Summary: Ectopic secretion of parathyroid hormone (PTH) by poorly-differentiated endometrial carcinoma led to life-threatening hypercalcemia in a 56-year-old woman, accompanied by nodular goiter mimic parathyroid tumors. Cytoreductive surgery (CRS) immediately reduced the levels of PTH and calcium. Pathological examination confirmed MMR-deficient endometrial carcinoma expressing PTH. The patient underwent four-course chemotherapy and one-course immunotherapy after CRS, but disease progression resulted in multiple organ failure and death. This is the first reported case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secretion, as well as the first report of malignancy-associated hypercalcemia complicated with nodular goiter.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
David R. Brown, Charles P. Burney, Grace K. Nevil, Phillip J. Gray, Mark A. Eid, Meredith J. Sorensen
Summary: This study investigates whether there are clinically significant differences in patients with extremely high baseline IOPTH and which IOPTH protocols are most appropriate for them. The results show that patients with extremely elevated baseline IOPTH are less likely to reach normal IOPTH levels, but postoperative calcium levels are comparable. Therefore, applying stricter IOPTH criteria for predicting biochemical cure may not be suitable for this population.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Davut Sakiz, Muhammed Erkam Sencar, Murat Calapkulu, Ilknur Ozturk Unsal, Muhammed Kizilgul, Bekir Ucan, Mustafa Ozbek, Erman Cakal
Summary: This study aims to evaluate the prevalence and risk factors associated with renal cysts in primary hyperparathyroidism (PHPT) patients. The findings suggest that a diagnosis of PHPT, high PTH levels, advanced age, and kidney stones are independent risk factors for simple renal cysts in PHPT patients.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Cell Biology
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan
Summary: This article reviews the effects of PTH, PTHrP, and PTH1R signaling on MSCs in the orofacial region, as well as the potential therapeutic applications for dental and bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Wei Shi, Xiajuan Wang, Jiayue Yang, Lan Xu, Ruifang Bu
Summary: Hypercalcemia is a clinical emergency that can cause hypercalcemic crisis due to the redistribution of calcium in bone and the inhibition of parathyroid secretion. This report presented a rare case of non-parathyroid hypercalcemia during lactation, with successful treatment involving calcitonin therapy and lactation termination to normalize serum calcium levels.
ANNALS OF PALLIATIVE MEDICINE
(2021)
