Article
Endocrinology & Metabolism
Etna Masip, Ester Donat, Begona Polo Miquel, Carmen Ribes-Koninckx
Summary: The study found that low bone mineral density is present at the onset of inflammatory bowel disease in Spanish pediatric patients. There were no differences in BMD between Crohn's disease and Ulcerative Colitis patients, but lower weight and height were associated with lower BMD, suggesting they should be considered as risk factors for bone disease in pediatric population with IBD.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Biology
Mariusz Olczyk, Elzbieta Czkwianianc, Anna Socha-Banasiak
Summary: In recent years, there has been an increase in the incidence of inflammatory bowel diseases in the pediatric population. However, there is a lack of research in this area, especially regarding metabolic disorders in patients with IBD.
Review
Medicine, General & Internal
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Smoking is a major modifiable risk factor for osteoporosis and can lead to various chronic diseases, including inflammatory bowel disease. Nicotine and compounds in cigarette smoke impact the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium-phosphate balance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Article
Immunology
Dengyong Xu, Yao Chen, Xing Gao, Weidong Xie, Ya Wang, Jiaying Shen, Guang Yang, Binbin Xie
Summary: This study conducted a two-sample Mendelian randomization analysis and found a causal relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), and low total body bone mineral density (BMD) and osteoporosis (OS).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Lili Ye, Yongwei Lin, Xing-di Fan, Yaoming Chen, Zengli Deng, Qian Yang, Xiaotian Lei, Jizong Mao, Chunhui Cui
Summary: The number of patients with Inflammatory bowel disease (IBD) is increasing globally. Researchers identified IBD-related genes using a SVM-based method based on disease similarities and gene interactions, achieving good results. The study highlights the importance of genetic factors in the occurrence of IBD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Christopher H. Arehart, John D. Sterrett, Rosanna L. Garris, Ruth E. Quispe-Pilco, Christopher R. Gignoux, Luke M. Evans, Maggie A. Stanislawski
Summary: Inflammatory bowel disease (IBD) is a complex condition with disrupted colonic ecosystem. A framework for multi-omic data analysis was used to study the gut ecosystem in IBD. Metabolomics and viromics were found to be more predictive than metagenomics or metatranscriptomics, and combining all four scores improved disease diagnosis prediction.
Article
Pediatrics
Hye-Young Jin, Jae-Sang Lim, Yena Lee, Yunha Choi, Seak-Hee Oh, Kyung-Mo Kim, Han-Wook Yoo, Jin-Ho Choi
Summary: Endocrine complications such as impaired growth, delayed puberty, and low bone mineral density are common in pediatric IBD patients. Vitamin D deficiency and osteoporosis are prevalent, while disease severity is associated with decreased weight-SDS, IGF-1-SDS, and testosterone levels. Optimal pubertal development is crucial for bone health.
Article
Gastroenterology & Hepatology
Joon Seop Lee, Hyun Seok Lee, Byung Ik Jang, Eun Soo Kim, Sung Kook Kim, Kyeong Ok Kim, Yoo Jin Lee, Hyun Jik Lee, Eun Young Kim, Yun Jin Lung, Chang Heon Yang
Summary: The study found that approximately one-third of newly diagnosed IBD Asian patients had low BMD. Clinical factors associated with low BMD included a high level of alkaline phosphatase in UC patients and being underweight in CD patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Medicine, General & Internal
Marta Carrillo-Palau, Alejandro Hernandez-Camba, Noemi Hernandez Alvarez-Buylla, Laura Ramos, Inmaculada Alonso-Abreu, Anjara Hernandez-Perez, Milagros Vela, Laura Arranz, Manuel Hernandez-Guerra, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study found that insulin resistance (IR) is not increased in inflammatory bowel disease (IBD) patients with low disease activity compared to controls. However, the presence of nonalcoholic fatty liver disease (NAFLD) favors the development of IR in patients with IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Gastroenterology & Hepatology
Charles N. Bernstein, Zoann Nugent, Seth Shaffer, Harminder Singh, Ruth Ann Marrie
Summary: Comorbidity is a significant predictor of disease course in IBD. The rates of certain component diseases of the Charlson Comorbidity Index were found to be increased both pre- and post-IBD diagnosis. Optimal care plans for persons with IBD should include assessment for a wide range of comorbidities involving multiple organ systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Pathology
Bence Kovari, Agnes Bathori, Mark S. Friedman, Gregory Y. Lauwers
Summary: Inflammatory bowel disease is a chronic inflammatory condition of the gastrointestinal tract, and the diagnosis relies on a synthesis of clinical, endoscopic, and microscopic features. The classic morphologic features of ulcerative colitis and Crohn disease include architectural distortion, basal plasmacytosis, and expansion of the lamina propria lymphoplasmacytic infiltrate.
ADVANCES IN ANATOMIC PATHOLOGY
(2022)
Article
Medicine, General & Internal
Edyta Maria Tulewicz-Marti, Konrad Lewandowski, Grazyna Rydzewska
Summary: Bone mineral alterations are common in patients with inflammatory bowel disease (IBD), especially in those with Crohn's disease (CD). This may be due to poor absorption, making CD patients vulnerable to changes in bone mineralization. Vitamin D supplementation is crucial, especially when taking corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2022)
