Article
Physiology
Lianguo Wang, Rachel C. Myles, I-Ju Lee, Donald M. Bers, Crystal M. Ripplinger
Summary: The study demonstrates that inhibition of SERCA can slow down SR Ca2+ reuptake, leading to an increase in the magnitude of Ca2+ alternans in cardiac cells, especially at fast pacing frequencies. Notably, the alternation of SR Ca2+ release precedes the alternation of SR Ca2+ load during rapid ventricular pacing.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ha Thu Nguyen, Carlos Noriega Polo, Andreas Wiederkehr, Claes B. Wollheim, Kyu-Sang Park
Summary: Enhancing endoplasmic reticulum (ER) calcium uptake through activation of the sarco/endoplasmic reticulum calcium ATPase (SERCA) can improve survival and function of pancreatic ss-cells. Activation of SERCA increases insulin synthesis and exocytosis, enhances sensitivity to glucose, and improves mitochondrial bioenergetics and antioxidant capability. Targeting SERCA could be a promising therapeutic strategy for protecting ss-cells from lipotoxicity and Type 2 diabetes development.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuan Xiong, Xiaoqin Zhang, Yuan Zhang, Jiaqi Xie, Yuan Bian, Qinan Yin, Rongsheng Tong, Dongke Yu, Lingai Pan
Summary: This study found that TCEP exposure can cause cardiac fibrosis by inhibiting the expression of SERCA and leading to Ca2+ overload, which in turn triggers ER stress and overactive autophagy. The results reveal the important role of the Ca2+ overload/ER stress/autophagy axis in TCEP-induced cardiotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Engineering, Environmental
Jing Zheng, Shane Antrobus, Wei Feng, Trevor N. Purdy, Bradley S. Moore, Isaac N. Pessah
Summary: This study found that bromopyrroles can influence neuronal network activity, with higher concentrations of TBP leading to a slow and sustained elevation in cytoplasmic calcium levels, ultimately resulting in loss of neuronal viability. The potential ecological and health impacts of bromopyrroles warrant further investigation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Cell Biology
Toyokazu Kimura, Kazuki Kagami, Atsushi Sato, Ayumu Osaki, Kei Ito, Shunpei Horii, Takumi Toya, Nobuyuki Masaki, Risako Yasuda, Yuji Nagatomo, Takeshi Adachi
Summary: This study found that SERCA2 protein expression decreased in the aorta of diabetic mice, and CDN1163 improved aortic endothelial dysfunction, glucose tolerance, hepatosteatosis, and skeletal muscle function in these mice.
Article
Oncology
Zhidong Li, Jia Guo, Yunfei Bian, Mingsheng Zhang
Summary: The study found that IMD can protect cardiomyocytes against thapsigargin-induced apoptosis, at least partially by activating the protein kinase A/SERCA pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Weixing Zhu, Yanwei Duan, Jiqiang Chen, Hans Merzendorfer, Xu Zou, Qing Yang
Summary: The study identified a novel role of DmSERCA in chitin synthesis, demonstrating its physical interaction with epidermal chitin synthase and its importance in chitin deposition and structure formation in Drosophila melanogaster.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Iyuki Namekata, Ryosuke Odaka, Shunsuke Hamazaki, Hina Nisaka, Shogo Hamaguchi, Hikaru Tanaka
Summary: A method using fluorescence microscopy and specific inhibitors was developed to evaluate the activity of NCX and SERCA in mouse ventricular cardiomyocytes. Different adrenoceptor stimulations and inhibitors exhibited distinct effects on cytoplasmic Ca2+ concentration in non-beating ventricular cardiomyocytes, suggesting potential applications for pharmacological evaluations targeting NCX and SERCA.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Anatomy & Morphology
Wanying Chen, Mengmeng Li, Xiangyu Lei, Yawen Cheng, Xiaoyu Wu, Xinyue Sun, Yixuan Wu, Zhiheng Li, Guogang Luo, Meng Wei
Summary: Our study found that remote ischemic postconditioning (RIPostC) can alleviate brain ischemic injury by reducing endoplasmic reticulum (ER) stress, providing a theoretical basis for the protective mechanism of ischemic stroke.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Fisheries
Junjie Yu, Wenrong Feng, Xue Chen, Changyou Song, Shengyan Su, Jiachun Ge, Yongkai Tang
Summary: This study cloned a cDNA encoding a putative SERCA protein from the Y-organs of E. sinensis. The Es-SERCA protein was widely expressed in various tissues, with the highest expression in the muscle. The study also revealed the functional role of SERCA in calcium homeostasis and its involvement in ecdysteroid synthesis during the moulting cycle.
AQUACULTURE RESEARCH
(2022)
Article
Cell Biology
Elisa Bovo, Roman Nikolaienko, Daniel Kahn, Ellen Cho, L. Seth Robia, V. Aleksey Zima
Summary: PS1 serves as an important regulator of cardiac Ca2+ pump function by interacting with SERCA2a, enhancing Ca2+ uptake at low ER Ca2+ loads and reducing uptake at high loads.
Article
Cardiac & Cardiovascular Systems
Jill K. Badin, Caleb Eggenberger, Stacey Dineen Rodenbeck, Zubair A. Hashmi, I-Wen Wang, Jose P. Garcia, Mouhamad Alloosh, Michael Sturek
Summary: In coronary smooth muscle of atherosclerotic coronary artery disease in metabolic syndrome swine, intracellular free Ca2+ dysregulation occurs. Increased [Ca2+](i) signaling in human CAD is associated with advanced age and a greater media area, while decreased signaling is related to a higher number of risk factors and plaque burden in human and swine CAD. Similar [Ca2+](i) dysregulation in human and Ossabaw swine CSM supports the translational relevance of this large animal model.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Review
Cell Biology
Eunhee Kim, Dong Min Lee, Min Ji Seo, Hong Jae Lee, Kyeong Sook Choi
Summary: Paraptosis is a type of programmed cell death characterized by dilation of the endoplasmic reticulum and/or mitochondria. Ca2+ transport has been shown to play an important role in paraptosis induced by various agents, and perturbations of cellular proteostasis and ion homeostasis are believed to contribute critically to the process. The communication between the ER and mitochondria mediated by Ca2+ appears to be crucial in inducing paraptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Benjamin Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, Maria E. Andres, Patrick Yu-Wai-Man, Gyoergy Hajnoczky, Veronica Eisner
Summary: Autosomal Dominant Optic Atrophy (ADOA), caused by OPA1 mutations, affects Ca2+ homeostasis by modulating ER-mitochondria coupling, potentially contributing to the progression of ADOA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Weimin Yu, Gang Xu, Hui Chen, Li Xiao, Gang Liu, Pingping Hu, Siqi Li, Vivi Kasim, Chunyu Zeng, Xiaoyong Tong
Summary: Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). This study identifies the impact of C674 oxidative inactivation on pulmonary vascular remodeling and PH development, highlighting the importance of C674 in maintaining pulmonary vascular homeostasis by restricting PASMC proliferation. The IRE1 alpha/XBP1s pathway and SERCA2 may serve as potential targets for PH therapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ji Hee Yu, Tung Nguyen, Yong-Il Kim, Soonshin Hwang, Kyung-Ho Kim, Chooryung J. Chung
Summary: The study found that contact or invasion of the maxillary central incisor roots to the incisive canal was fairly high after maximum anterior retraction, while there were no significant changes in the shape of the incisive canal.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joo-Hee Chun, Amanda Cunha Regal de Castro, Sunmee Oh, Kyung-Ho Kim, Sung-Hwan Choi, Lincoln Issamu Nojima, Matilde da Cunha Goncalves Nojima, Kee-Joon Lee
Summary: This study evaluated the immediate and short-term effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) on skeletal, dentoalveolar, and periodontal outcomes in patients. The results showed that the MARPE group had less decrease in skeletal, dentoalveolar, and periodontal variables after consolidation compared to the RPE group. The combination of RPE with miniscrews contributed to the maintenance of basal bone during the consolidation period.
Article
Dentistry, Oral Surgery & Medicine
Y. S. Park, J. H. Choi, Y. Kim, S. H. Choi, J. H. Lee, K. H. Kim, C. J. Chung
Summary: With the increase of adult orthodontic population, an accurate and evidence-based prediction of posttreatment face in 3D is needed. This study developed a 3D postorthodontic face prediction method based on a deep learning network using patient-specific factors and orthodontic treatment conditions. The proposed method showed similar 3D changes to the real posttreatment face and had high accuracy.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Toxicology
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong, Dong Min Shin
Summary: The study found that 8-estradiol treatment attenuated the oxalate or bicarbonate transporting activities through SLC26A6 and enhanced cancer cell migration. Even in the presence of 8-estradiol treatment, increased SLC26A6 expression weakened cellular migration. These results suggest that 8-estradiol treatment enhances cancer cell migration by inhibiting SLC26A6 activity.
TOXICOLOGY IN VITRO
(2022)
Article
Dentistry, Oral Surgery & Medicine
Won Lee, Hosik Jang, Sun-Hyung Park, Dong Won Lee, Ji Hyun Lee, Kyung-Ho Kim, Tung Nguyen, Chooryung J. Chung
Summary: This study evaluated the incidence of LPs after orthodontic treatment and their associated etiology and clinical risk factors. The results showed that adult males and patients who underwent tooth extraction had a higher risk of developing LPs.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sun-Hyung Park, Sang Su An, Chooryung J. Chung, Yoon Jeong Choi, Woo Chan Hwang, Kyung-Ho Kim
Summary: This study reports the treatment of an adult patient with deepbite and severe crowding of teeth. Successful treatment results were achieved through tooth extractions and restorations, with long-term retention.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Seunghee Ma, Sun-Hyung Park, Chooryung J. Chung, Yoon Jeong Choi, Won Lee, Kyung-Ho Kim
Summary: This study evaluated the changes in the alveolar bone and adjacent teeth in patients with a congenitally missing mandibular lateral incisor using cone-beam computed tomography. The results showed that the congenitally missing mandibular lateral incisor caused a reduction in arch perimeter in the CEJ area and the RA area, and root divergences were observed in the teeth adjacent to the missing areas. A significant decrease in buccal cortical bone and cancellous bone was observed in the missing area.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ji-hye Nam, Youngjun Choi, Kee-Joon Lee, Ji-Hyun Lee, Kyung-Ho Kim, Chooryung J. Chung
Summary: This study evaluated and compared the 3-dimensional aging changes of the lips among adult skeletal Class I, II, and III malocclusion. The results showed that middle-aged adult females had a lower upper lip height and greater mouth width compared to younger females, regardless of skeletal malocclusion. However, significant morphologic aging changes of the lips were noted in different locations depending on the type of skeletal malocclusion.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Insil Kim, Sun-Hyung Park, Yoon Jeong Choi, Ji Hyun Lee, Chooryung J. Chung, Kyung-Ho Kim
Summary: This study evaluated the occlusal status of spontaneously erupted maxillary third molars after extraction of the maxillary second molars and investigated the factors that influenced their occlusal status. The results showed that 65.4% of the maxillary third molars had good-to-acceptable occlusion after extraction. Insufficient increase in the maxillary tuberosity space and Nolla stage 8 or higher at the time of extraction negatively influenced the eruption of the maxillary third molars.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chaehee Oh, Hyuna Lee, Jean Kim, Ji Hyun Lee, Tung Nguyen, Kyung-Ho Kim, Chooryung J. Chung
Summary: This study aimed to validate the application of near-infrared imaging (NIRI) to evaluate craze lines and determine the influence of age and orthodontic debonding on their prevalence and severity. The results showed that NIRI reliably detected craze lines, and the prevalence of craze lines was higher in adults than in adolescents. Orthodontic debonding did not affect the severity of craze lines.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hyejin Kwon, Sun-Hyung Park, Hoi-In Jung, Woo-Chan Hwang, Yoon Jeong Choi, Chooryung Chung, Kyung-Ho Kim
Summary: The study compared changes in occlusal contact area (OCA) and bite force (BF) before and after orthognathic surgery in mandibular prognathic patients with mandibular asymmetry. The results showed that OCA and BF gradually decreased before surgery and increased after surgery on both sides. There was a significant difference in OCA and BF between the deviated and non-deviated sides before surgery, but no difference after surgery. The change in mandibular plane angle had a significant effect on BF during the observation period, particularly on the non-deviated side.
KOREAN JOURNAL OF ORTHODONTICS
(2022)
Article
Biochemistry & Molecular Biology
Minjeong Ji, Hee Jung Ryu, Hyeon-Man Baek, Dong Min Shin, Jeong Hee Hong
Summary: The study found that modulation of the migratory module of fibroblast-like synoviocytes (FLSs) can attenuate the severity of rheumatoid arthritis (RA). The sodium bicarbonate cotransporter n1 (NBCn1) was identified in RA-FLSs and inhibiting NBCs reduced FLS migration and RA symptoms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)