Article
Medicine, General & Internal
Ying-Hao Wen, Wei-Tzu Lin, Wei-Ting Wang, Ding-Ping Chen
Summary: Transfusion reactions may be associated with CD28 and CTLA4 gene polymorphisms, with specific SNPs linked to an increased risk. This study found an association between the rs3181097 polymorphism of CD28 and transfusion reactions, potentially regulating immune response by decreasing CD28 protein expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Pavel Marozik, Alena Rudenka, Katsiaryna Kobets, Ema Rudenka
Summary: This study demonstrated significant effects of VDR gene variants ApaI rs7975232, BsmI rs1544410, TaqI rs731236, and Cdx2 rs11568820 on bone mineral density, 25-hydroxyvitamin D level, and osteoporosis risk in Belarusian women. The findings suggest the importance of genetic markers for personalized medicine strategies.
Article
Geriatrics & Gerontology
A. Kojima, K. Kamiya, E. Kajita, T. Tachiki, Y. Sato, K. Kouda, K. Uenishi, J. Tamaki, S. Kagamimori, M. Iki
Summary: This study aimed to investigate the relationship between the frequency of dairy product intake and the risk of osteoporotic fractures in Asians. The findings suggest that habitual milk intake can decrease the risk of osteoporotic fractures in postmenopausal Japanese women.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Medicine, General & Internal
Masashi Uehara, Yukio Nakamura, Takako Suzuki, Masaki Nakano, Jun Takahashi
Summary: This study compared the efficacy and safety of ibandronate and zoledronic acid in Japanese postmenopausal osteoporotic patients, finding that both drugs significantly and safely improved bone turnover markers and BMD during 30 months of treatment. The ZOL group tended to exhibit greater gains in BMD compared to the IBN group, warranting further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takashi Kanno, Changmin Kim, Daisuke Yamanaka, Ken-ichi Ishibashi, Hiroshi Tanaka, Naohito Ohno, Yoshiyuki Adachi
Summary: The study found that components in Japanese cedar pollen may lead to false positives when testing for deep mycosis. Care should be taken to consider the possibility of contamination from Japanese cedar pollen when conducting tests.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lin Zhou, Cheng Li, Hao Zhang
Summary: This study analyzed the correlation between bone mineral density (BMD) at different sites and lumbar disc degeneration (LDD) in postmenopausal women and explored the potential pathophysiological mechanism. The results showed a positive correlation between lumbar BMD and LDD, especially in the upper lumbar spine segments. However, there was no correlation between hip BMD and LDD, suggesting that hip BMD is more suitable for diagnosing osteoporosis in postmenopausal women with lumbar degenerative disease.
Article
Genetics & Heredity
Yi-Ming Guo, Jian-Hao Cheng, Hao Zhang, Jin-Wei He, Hua Yue, Wei-Wei Hu, Jie-Mei Gu, Yun-Qiu Hu, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: This study investigated the association between genetic variation of the POSTN gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women. The study found that the rs9603226 variant of POSTN was significantly associated with vertebral fractures, while the rs3923854 variant was associated with serum periostin levels. These findings suggest that genetic variation of the POSTN gene may be a predicting factor for the risk of vertebral fractures, and serum periostin levels could be a potential biochemical parameter for osteoporosis in Chinese postmenopausal women.
Article
Biochemistry & Molecular Biology
Coralie Robert, Julien Marquevielle, Gilmar F. Salgado
Summary: This study investigated whether the promoter region of the MST1R gene contains potential G-quadruplex structures and characterized the best scored sequences using biophysical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Alejandra Villagomez Vega, Jorge Ivan Gamez Nava, Francisco Ruiz Gonzalez, Misael Perez Romero, Walter angel Trujillo Rangel, Ismael Nuno Arana
Summary: This study aimed to investigate the influence of combinations of potential risk alleles on the response to anti-osteoporotic treatment in postmenopausal women with primary osteoporosis. The results showed that patients with the G-C-G-C genetic profile were more likely to respond positively to alendronate therapy.
Article
Genetics & Heredity
Rong Sun, Ryosuke Tanino, Xuexia Tong, Minoru Isomura, Li-Jun Chen, Takamasa Hotta, Tamio Okimoto, Megumi Hamaguchi, Shunichi Hamaguchi, Yasuyuki Taooka, Takeshi Isobe, Yukari Tsubata
Summary: The COX-2 -1195A genotype is associated with an increased risk for lung squamous cell carcinoma in the Japanese population, but not adenocarcinoma. However, it does not correlate with the overall survival of patients with lung squamous cell carcinoma.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Wen-Jie Wang, Jin-Wei He, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: The study found a significant association between the NF-kappa B1 and RELA genes and bone response to zoledronic treatment in postmenopausal Chinese women with osteoporosis, with certain haplotypes being related to improvements in bone density.
Article
Veterinary Sciences
Zhihua Chen, Diwen Yao, Dongchun Guo, Yuan Sun, Lu Liu, Mingxing Kou, Xiuqin Yang, Shengwei Di, Jiancheng Cai, Xibiao Wang, Buyue Niu
Summary: The present study identified functional mutations in the promoter of porcine STAT3 that are associated with piglet diarrhea. Further analysis revealed that one of the mutations, SNP1: g.-870 G>A, directly affected the transcription efficiency of STAT3, potentially contributing to susceptibility or resistance to piglet diarrhea.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jia-Hao Yuan, Jia-Li Tu, Guo-Cai Liu, Xiu-Cai Chen, Zhi-Shu Huang, Shuo-Bin Chen, Jia-Heng Tan
Summary: In this study, a new fluorescent probe ISCH-MYC was developed for specific recognition of c-MYC G-quadruplex based on the G-quadruplex-Triggered Fluorogenic Hybridization (GTFH) strategy. The probe allowed for the detection of duplex-quadruplex transition in c-MYC G-rich DNA in cells, and was used to study the interactions of transcription factors Sp1 and CNBP with c-MYC G-rich DNA in the presence of G-quadruplex stabilizing ligand PDS. This research provides a visualization strategy for exploring the mechanism of G-quadruplex stabilizing ligands on c-MYC G-rich DNA and relevant proteins.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Immunology
Xueli Yang, Tian Chang, Qian Yuan, Wei Wei, Pingping Wang, Xiaojian Song, Huijuan Yuan
Summary: This study investigates the variations in gut microbiota (GM) and vaginal microbiota (VM) in postmenopausal women with osteoporosis. The results show that changes in bone mineral density are associated with changes in GM and VM, with GM being more closely correlated with postmenopausal osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
