Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Izadora de Souza, Maria Carolina Clares Ramalho, Camila Banca Guedes, Isabeli Yumi Araujo Osawa, Linda Karolynne Seregni Monteiro, Luciana Rodrigues Gomes, Clarissa Ribeiro Reily Rocha
Summary: Glioblastoma multiforme is a lethal disease characterized by drug resistance and evasion of cell death. Ferroptosis, a recently described type of cell death, holds potential as a promising approach for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ritu Arora, Jin-Hwan Kim, Ayechew A. Getu, Anusha Angajala, Yih-Lin Chen, Bin Wang, Andrea G. Kahn, Hong Chen, Latif Reshi, Jianrong Lu, Wenling Zhang, Ming Zhou, Ming Tan
Summary: The highly expressed MST4 gene in breast cancer promotes cell growth, migration, invasion, and epithelial-mesenchymal transition (EMT). It is associated with cancer stage, lymph node metastasis, and poor overall survival.
Article
Multidisciplinary Sciences
Junjie Gao, Dandan Yang, Zheng Huang, Xueshan Pan, Ruoxue Cao, Chaoqun Lian, Jia Ma, Yuyun Li, Zhiwei Wang, Jun Xia
Summary: Nitric oxide synthase-interacting protein (Nosip) interacts with nitric oxide synthase (NOS) and regulates NO synthesis and release, participating in various physiological and pathological processes. Nosip was found to be elevated in hepatocellular carcinoma (HCC) tissues and cells. Silencing Nosip inhibited HCC cell proliferation and motility, and promoted apoptosis, while overexpression of Nosip had the opposite effects. Quercetin, a natural compound, inhibited the proliferation and motility of HCC cells possibly by repressing Nosip expression. Our findings suggest that Nosip acts as an oncogene in HCC progression and quercetin may be a potential natural compound for treating HCC by targeting Nosip expression.
Review
Pharmacology & Pharmacy
Kadirvel Devi, Thukani Sathanantham Shanmugarajan
Summary: This article discusses the mechanisms of osteoporosis and the limitations of current treatment methods. It highlights the importance of cell apoptosis in bone growth and maintenance, and explores the potential role of plant metabolites in apoptosis regulation.
CURRENT DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Manzar Alam, Sabeeha Ali, Taj Mohammad, Gulam Mustafa Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Summary: Defects in apoptosis mechanism can enhance cancer cell growth and survival. Bcl-2, as an important anti-apoptotic molecule, is over-expressed in various cancers and has become a target for novel anti-tumor treatments. BH3-mimetics are emerging as promising compounds for cancer therapy, with ongoing clinical trials targeting Bcl-2 for multiple cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chelsea A. Crossley, Vishaal Rajani, Qi Yuan
Summary: Calcium plays a crucial role in various cellular processes and signaling pathways in the human body. L-type calcium channels (LTCCs), such as voltage-gated calcium channels, are essential for neurotransmitter release, synaptic integration, and plasticity in the nervous system. Dysfunction of LTCCs has been implicated in aging and Alzheimer's Disease (AD), making them a promising target for AD treatment. However, the mechanisms by which LTCCs contribute to AD are still not fully understood due to their complexity. This review provides an overview of the structure, function, and modulation of LTCCs, highlighting the potential of targeting molecular pathways that up-regulate LTCCs as a more effective approach in AD, considering the diverse physiological functions of LTCCs and the limited success of LTCC blockers in clinical studies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Chelsea A. Crossley, Vishaal Rajani, Qi Yuan
Summary: Calcium is essential for various signaling pathways and cellular processes in the human body. L-type calcium channels (LTCCs) play a critical role in the nervous system, mediating neurotransmitter release, synaptic integration, and plasticity. Dysfunction of LTCCs has been linked to aging and Alzheimer's Disease (AD), making them a potential target for AD treatment. However, the mechanisms by which LTCCs contribute to AD are still unclear. This review provides an overview of the structure, function, and modulation of LTCCs, suggesting that targeting molecular pathways that up-regulate LTCCs may be a more promising approach in AD.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Immunology
Siqi Li, Qiong Huang, Dongbo Zhou, Baimei He
Summary: This review discusses the roles and mechanisms of PRKCD in the development of chronic obstructive pulmonary disease (COPD), suggesting that PRKCD contributes to COPD by promoting inflammatory response, apoptosis, mitochondrial dysfunction, and MUC5AC hypersecretion, and highlighting the potential of PRKCD as a therapeutic target for COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Meng Chen, Guobin Li, Lan Zhang, Kaiting Ning, Baoqiang Yang, Jean X. Jiang, Dong-En Wang, Huiyun Xu
Summary: Osteocytes can release small molecules through Cx43 channels, affecting metabolic pathways related to inflammation and oxidative stress. This study identified potential metabolites released by osteocytes through Cx43 channels, providing new insights into the regulatory mechanisms of osteocytes on themselves and other cells.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Wenliang Tan, Kelin Zhang, Xinming Chen, Lei Yang, Sicong Zhu, Yingcheng Wei, Zhiqin Xie, Yajin Chen, Changzhen Shang
Summary: This study revealed that Lenvatinib can induce apoptosis in HCC cells by increasing reactive oxygen species levels, with GPX2 identified as a crucial target for Lenvatinib against HCC. It was found that GPX2 was highly expressed in tumor tissues and correlated with poor overall survival in HCC patients. Furthermore, Lenvatinib was shown to inhibit GPX2 expression in HCC cells by preventing the nuclear translocation of β-catenin. These findings suggest that GPX2 may play an important role in Lenvatinib-induced HCC cell apoptosis and can serve as a biomarker for guiding Lenvatinib therapy in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Multidisciplinary Sciences
Hua Wu, Xue-qin Lin, Yu Long, Jing Wang
Summary: Osteoporosis, a skeletal disorder characterized by decreased bone mineral density, is becoming more prevalent in an aging population. Calcitonin gene-related peptide (CGRP) has shown potential in promoting bone homeostasis by stimulating osteogenesis and bone absorption. However, there is still limited development in the clinical application of CGRP for osteoporosis treatment.
Review
Oncology
Vaibhav Jain, Swaroop Bose, Awadhesh K. Arya, Tasleem Arif
Summary: Lysosomes are critical components involved in cellular biological processes and play a crucial role in cellular metabolism, cancer, and the maintenance of hematopoietic stem cells. Targeting lysosomes has therapeutic potential in acute myeloid leukemia.
Review
Medicine, General & Internal
Kok-Yong Chin, Ben Nett Ng, Muhd Khairik Imran Rostam, Nur Farah Dhaniyah Muhammad Fadzil, Vaishnavi Raman, Farzana Mohamed Yunus, Syed Alhafiz Syed Hashim, Sophia Ogechi Ekeuku
Summary: This review provides an overview of osteoporosis, including its biology, epidemiology, and clinical aspects, serving as an updated reference for readers to understand the basics of the disease and take preventive and management actions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xiaoyin Ye, Tong Zhang, Han Han
Summary: The activation of FXR receptor can reduce bile acid synthesis and alleviate cholestasis, but the unresponsiveness of some patients and side effects of UDCA or OCA treatment limit their effectiveness. Therefore, researchers have begun to investigate the role of PPARα receptor in regulating bile acid metabolism and transport, and have found its anti-inflammatory effects that can improve the physiological status of patients with cholestatic liver disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Francesca Fontana, Xia Ge, Xinming Su, Deep Hathi, Jingyu Xiang, Simone Cenci, Roberto Civitelli, Kooresh I. Shoghi, Walter J. Akers, Andre D'avignon, Katherine N. Weilbaecher, Monica Shokeen
CLINICAL CANCER RESEARCH
(2017)
Editorial Material
Endocrinology & Metabolism
Roberto Civitelli
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Giulia Leanza, Rocky Strollo, Paolo Pozzilli, Roberto Civitelli, Nicola Napoli
Editorial Material
Endocrinology & Metabolism
Roberto Civitelli, Jennifer Westendorf, Lorenz Hofbauer, Fernando Rivadeneira
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Editorial Material
Endocrinology & Metabolism
Roberto Civitelli, Katie Duffy
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Canxin Xu, Dustin Kress, Roberto Civitelli, Yousef Abu-Amer, Thirumala-Devi Kanneganti, Daniel C. Link, Gabriel Mbalaviele
Article
Cell Biology
Lauren E. Surface, Damon T. Burrow, Jinmei Li, Jiwoong Park, Sandeep Kumar, Cheng Lyu, Niki Song, Zhou Yu, Abbhirami Rajagopal, Yangjin Bae, Brendan H. Lee, Steven Mumm, Charles C. Gu, Jonathan C. Baker, Mahshid Mohseni, Melissa Sum, Margaret Huskey, Shenghui Duan, Vinieth N. Bijanki, Roberto Civitelli, Michael J. Gardner, Chris M. McAndrew, William M. Ricci, Christina A. Gurnett, Kathryn Diemer, Fei Wan, Christina L. Costantino, Kristen M. Shannon, Noopur Raje, Thomas B. Dodson, Daniel A. Haber, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, Kivanc Birsoy, David M. Sabatini, Gabe Haller, Timothy R. Peterson
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Meeting Abstract
Endocrinology & Metabolism
Biancamaria Ricci, Francesca Fontana, Sahil Mahajan, Roberto Civitelli, Roberta Faccio
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Francesca Fontana, Marcus Watkins, Song Dah Woon, Giulia Leanza, Roberto Civitelli
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Giulia Leanza, Francesca Fontana, Rocky Strollo, Paolo Pozzilli, Nicola Napoli, Roberto Civitelli
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Endocrinology & Metabolism
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Dustin Kress, Guillermo Blanco, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Meeting Abstract
Hematology
Grazia Abou Ezzi, Joseph Ryan Mosqueda, Teerawit Supakorndej, Jingzhu Zhang, Roberto Civitelli, Daniel C. Link
Meeting Abstract
Endocrinology & Metabolism
Biancamaria Ricci, Francesca Fontana, Sahil Mahajan, Danielle Ketterer, Roberto Civitelli, Roberta Faccio
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Endocrinology & Metabolism
Francesca Fontana, Biancamaria Ricci, Jingyu Xiang, Xinming Su, Giulia Leanza, Roberta Faccio, Katherine Weilbaecher, Roberto Civitelli
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Endocrinology & Metabolism
Yael Alippe, Chung Wang, Biancamaria Ricci, Jianqiu Xiao, Wei Zou, Deborah Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
