Article
Orthopedics
Michael A. Friedman, Evan G. Buettmann, Yasmina Zeineddine, Lovell B. Abraham, Gabriel A. Hoppock, Steven J. Meas, Yue Zhang, Charles R. Farber, Henry J. Donahue
Summary: Genetic variation affects the skeletal response to mechanical unloading differently in different mouse strains, leading to significant catabolic effects on bone metabolism in some strains.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biophysics
Mustafa Unal
Summary: Raman spectroscopy-derived measurements are associated with mechanical properties of human cortical bone, and the combination of multiple spectral parameters can improve the prediction accuracy. Using multivariate linear regression and Spearman's rank correlations, the best predictive methods can be determined, providing a basis for assessing fracture risk.
JOURNAL OF BIOMECHANICS
(2021)
Article
Clinical Neurology
Tony M. Keaveny, Annette L. Adams, Heidi Fischer, Harsimran S. Brara, Shane Burch, Kern H. Guppy, David L. Kopperdahl
Summary: Biomechanical computed tomography analysis (BCT) was effective in identifying patients aged 50 or older with osteoporosis who underwent spinal fusion and were at elevated risks of reoperation and vertebral fracture.
Article
Engineering, Manufacturing
Yu-Tzu Wang, Chun-Ming Chang, Pei-Hsin Liu, Chun-Li Lin
Summary: Porous titanium implant surfaces fabricated using additive manufacturing can enhance bone-implant stability. A new lattice type implant was designed to improve bone ingrowth efficiency and interfacial bonded strength. The experiment showed that the new lattice implant had significantly higher bonded strength compared to the traditional implant.
ADDITIVE MANUFACTURING
(2023)
Article
Biotechnology & Applied Microbiology
Ahmed Arslan, Zhuoqing Fang, Meiyue Wang, Yalun Tan, Zhuanfen Cheng, Xinyu Chen, Yuan Guan, Laura J. Pisani, Boyoung Yoo, Gill Bejerano, Gary Peltz
Summary: Long read sequencing is a useful method for identifying structural variants causing human genetic diseases. In this study, the genomes of six inbred strains were sequenced using long read sequencing, and it was found that structural variants are abundant and cannot be accurately detected using short read sequencing. The advantage of a more complete map of genetic variation was demonstrated by analyzing the genomic sequence of BTBR mice and identifying a unique deletion contributing to neuroanatomic abnormalities.
Article
Biology
V. David Munteanu, Kelly M. Diamond, Richard W. Blob
Summary: Across vertebrate diversity, limb bone morphology can reflect differences in habitats and functional tasks. Arboreal vertebrates usually have longer limbs to reach across branches. However, changes in habitat or behavior can affect bone loading. In the case of green iguanas, limb bone adaptations in arboreal habitats were driven by other selective pressures instead of skeletal loading.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Orthopedics
Hadi Moeinnia, Amir Nourani, Mahdi Mohseni, Amirhossein Borjali, Narges Ghias, Hossein Korani, Mahmoud Chizari
Summary: This study investigated the effects of drill bit and tendon diameter on Core Bone Engaged Length (CBEL) and fixation strength in BASHTI technique. The results showed that while 6 mm tendon group had the greatest CBEL, its fixation strength was insufficient. The fixation strength for 7, 8, and 9 mm tendon diameter groups were similar, but their CBELs varied significantly.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Cell Biology
Uma P. Arora, Beth A. Sullivan, Beth L. Dumont
Summary: This study investigates the interplay between centromere variation and kinetochore protein sequence association in mice, and reveals strain-level differences in both CENP-A positioning and sequence preference along the core centromere satellite.
Article
Agriculture, Dairy & Animal Science
Vanessa E. Dahl, Ellen R. Singer, Tanya C. Garcia, David A. Hawkins, Susan M. Stover
Summary: Racehorses with underrun heel hoof conformation are often shod with nails placed toward the heel. It is unknown if palmar nails restrict or alter hoof deformation in a manner that could promote the development of underrun heel conformation over time. The study found that palmar nails decreased heel expansion and resulted in significant changes in hoof wall deformation.
Article
Multidisciplinary Sciences
Matthias Munz, Mohammad Khodaygani, Zouhair Aherrahrou, Hauke Busch, Inken Wohlers
Summary: Mice have been extensively used as animal models to study genotype to phenotype relationships, with inbred mice being particularly useful due to genetic homogeneity. A method for in silico fine-mapping using genotypic data of 37 inbred mouse strains and user-provided phenotypic data is presented in this study. This method efficiently queries public genome-wide genotype data to propose candidate variants and genes for the phenotype under study.
Article
Biophysics
Serkan Gurgul, Ozlem Keskin, Can Demirel, Mehmet Yasar Ozkars, Yahya Nural
Summary: There is evidence suggesting that allergic asthma may pose a risk to bone health. While the use of anti-IgE therapy has proven effective in treating allergic asthma, its effects on bone health are still unknown. This study aimed to investigate the impact of chronic allergic asthma on bone and whether anti-IgE therapy can prevent any adverse changes. The findings suggest that chronic allergic asthma can lead to bone loss and a decrease in bone strength, but administration of anti-IgE may inhibit these impairments in a dose-dependent manner.
JOURNAL OF BIOMECHANICS
(2022)
Article
Endocrinology & Metabolism
Adrienn Markovics, Sydney Lupo, Niyati Patel, Katalin Mikecz, D. Rick Sumner, Ryan D. Ross
Summary: This study found that Shp1 overexpression leads to increased bone mass and improved mechanical properties in mice, but only in 28-day-old mice. Female SHP1-Tg mice showed higher trabecular bone volume, trabecular number, and connectivity density compared to wildtype mice.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Anna L. Tyler, Catrina Spruce, Romy Kursawe, Annat Haber, Robyn L. Ball, Wendy A. Pitman, Alexander D. Fine, Narayanan Raghupathy, Michael Walker, Vivek M. Philip, Christopher L. Baker, J. Matthew Mahoney, Gary A. Churchill, Jennifer J. Trowbridge, Michael L. Stitzel, Kenneth Paigen, Petko M. Petkov, Gregory W. Carter
Summary: This study investigates the epigenetic diversity of the Diversity Outbred (DO) mice and their founders, finding highly variable epigenetic landscapes that are associated with gene expression variation. They demonstrate that both histone modifications and DNA methylation are heritable mechanisms of gene expression regulation and provide a valuable resource documenting strain-specific variation in chromatin state and DNA methylation in hepatocytes across nine widely used strains of laboratory mice.
Article
Agriculture, Dairy & Animal Science
Charlene Hanlon, Kayo Takeshima, Elijah G. Kiarie, Gregoy Y. Bedecarrats
Summary: Decades of genetic selection in commercial layers have led to earlier maturation without compromising high production rates. Variations in skeletal growth, bone density, and egg quality were observed among different strains. Blood plasma calcium levels differed significantly among the strains.
Article
Chemistry, Multidisciplinary
Shaojun Dong, Zhongdong Gan, Xinyan Chen, Ying Pei, Bin Li, Jing Ren, Yanlei Wang, Hongyan He, Shengjie Ling
Summary: By utilizing conductive ionic silk fibroin to regulate the carbon nanotube interface, ductile and damage-tolerant CNT fibers with improved mechanical performance and high conductivity were designed, showing promising potential in flexible and wearable devices, such as smart textiles, artificial muscles, and human-machine interfaces.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Orthopedics
Amelie Sas, Esther Tanck, Hazem Wafa, Yvette van der Linden, An Sermon, G. Harry van Lenthe
Summary: This study aimed to evaluate the accuracy of a finite element model in predicting bone fracture in cancer patients with proximal femoral bone metastases and to assess the effectiveness of femoroplasty in reducing fracture risk. The results suggest that femoroplasty can effectively reduce the risk of fracture in osteolytic lesions located in the femoral head/neck.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Engineering, Biomedical
Jenny Gehlen, Wanwan Qiu, Gian Nutal Schadli, Ralph Mueller, Xiao-Hua Qin
Summary: Tomographic volumetric bioprinting (VBP) is a powerful tool for rapid solidification of cell-laden hydrogel constructs. This study explores the application of VBP in bone tissue engineering by merging GelMA bioresin with 3D endothelial co-culture. The optimal formulation for VBP of complex perfusable constructs with high cell viability was identified.
ACTA BIOMATERIALIA
(2023)
Article
Endocrinology & Metabolism
Kenneth Guangpu Yang, Elliott Goff, Ka-lo Cheng, Gisela A. Kuhn, Yujia Wang, Jack Chun-yiu Cheng, Yong Qiu, Ralph Muller, Wayne Yuk-wai Lee
Summary: The study aimed to validate abnormal osteocyte lacunar morphology in adolescent idiopathic scoliosis (AIS) through a large-scale comparison of morphological features between AIS patients and controls in spine and ilium. Results showed that AIS patients had more oblate osteocyte lacunae in the iliac bone, which is less affected by asymmetric loading of the deformed spine, and the shape of osteocyte lacunae in the iliac bone was associated with the radiological Cobb angle in AIS patients. Osteocyte lacunae on the concave side of scoliotic curves were more stretched in both AIS and congenital scoliosis (CS) groups, likely due to asymmetric mechanical loading.
Review
Endocrinology & Metabolism
Matthias Walle, Danielle E. Whittier, Morten Frost, Ralph Mueller, Caitlyn J. Collins
Summary: Diabetes mellitus is associated with changes in bone microarchitecture, with T1DM primarily affecting trabecular bone and T2DM mainly impacting cortical bone. Adverse effects are more pronounced at the radius, suggesting mechanical loading may mitigate these changes. Identifying bone structure abnormalities in T1DM and T2DM could aid in developing animal models for skeletal fragility in diabetes.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Endocrinology & Metabolism
Matthias Walle, Dominic Eggemann, Penny R. Atkins, Jack J. Kendall, Kerstin Stock, Ralph Muller, Caitlyn J. Collins
Summary: Motion artefacts in high-resolution peripheral quantitative computed tomography (HR-pQCT) can degrade image quality and affect measurements of bone density, morphology, and mechanical properties. This study developed a Convolutional Neural Network (CNN) that can predict motion scores from HR-pQCT images and identify uncertain predictions that require manual confirmation. The CNN achieved high accuracy and substantial agreement, and can significantly reduce the time for quality assessment and control of HR-pQCT scans.
Article
Engineering, Biomedical
Alexandra Tits, Stephane Blouin, Maximilian Rummler, Jean-Francois Kaux, Pierre Drion, G. Harry van Lenthe, Richard Weinkamer, Markus A. Hartmann, Davide Ruffoni
Summary: The attachment of tendon to bone at entheses is a demanding task for the musculoskeletal system. We analyzed mineralized fibrocartilage (FC) and subchondral bone at the Achilles tendon-bone insertion of rats and found that FC had lower mineralization but higher stiffness and hardness compared to bone. The different structure-property relationships of enthesis FC and periosteal FC demonstrate the versatility of FC in providing strength and compliance.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Wanwan Qiu, Jenny Gehlen, Margherita Bernero, Christian Gehre, Gian Nutal Schaedli, Ralph Mueller, Xiao-Hua Qin
Summary: Tomographic volumetric bioprinting (VBP) allows fast fabrication of cell-laden hydrogel constructs using a dynamic resin based on thiol-ene photo-clickable polyvinyl alcohol (PVA) and thermo-sensitive sacrificial gelatin. This technique enables rapid cell spreading, 3D osteogenic differentiation, and matrix mineralization. It also allows site-specific immobilization of molecules-of-interest inside a PVA hydrogel. Overall, this study introduces a synthetic dynamic photoresin that enables fast fabrication of functional ultrasoft hydrogel constructs with well-defined physicochemical properties.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Correction
Engineering, Biomedical
Jianhua Zhang, Esther Wehrle, Jolanda R. Vetsch, Graeme R. Paul, Marina Rubert, Ralph Mueller
BIOMEDICAL MATERIALS
(2023)
Article
Biophysics
Stephanie L. Kahmann, Amelie Sas, Nils Grose Hokam, G. Harry van Lenthe, Lars-Peter Mueller, Kilian Wegmann
Summary: Elbow trauma can lead to a loss of independence in daily self-care activities and have a negative impact on patients' quality of life. Finite element models provide valuable insights into native joint mechanics and play a crucial role in restoring joint functionality after severe injuries. This study aimed to develop a finite element model of the elbow, including both the radio-capitellar and ulno-trochlear joints, and subjected to loads representative of daily activities.
JOURNAL OF BIOMECHANICS
(2023)
Article
Biology
Andrea Benova, Michaela Ferencakova, Kristina Bardova, Jiri Funda, Jan Prochazka, Frantisek Spoutil, Tomas Cajka, Martina Dzubanova, Tim Balcaen, Greet Kerckhofs, Wouter Willekens, G. Harry van Lenthe, Arzuv Charyyeva, Glenda Alquicer, Alena Pecinova, Tomas Mracek, Olga Horakova, Roman Coupeau, Morten Svarer Hansen, Martin Rossmeisl, Jan Kopecky, Michaela Tencerova
Summary: This study demonstrates that supplementation of omega-3 PUFAs can improve bone health, reduce bone marrow adipose tissue formation, and promote osteoblast differentiation in obese mice.
COMMUNICATIONS BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Woelfel, Charlotte Ejersted, Gisela Kuhn, Ralph Mueller, Morten Frost
Summary: Clinical studies have shown that microvascular disease (MVD) can affect bone microstructure and decrease bone strength in patients with type 2 diabetes mellitus (T2D). This study collected bone biopsies from T2D patients and found that MVD may alter the morphometric parameters of osteocyte lacunae. Additionally, the study revealed that trabecular bone lacunar density was associated with glycated hemoglobin (HbA1c), independent of MVD.
Article
Cell & Tissue Engineering
W. Colyn, F. Azari, J. Bellemans, G. Harry van Lenthe, L. Scheys
Summary: Recent studies have shown the important role of subchondral bone in the development of OA. However, limited data is available on the relationship between cartilage morphology, subchondral bone plate (SBP) structure, and subchondral trabecular bone (STB). This study aimed to visualize and quantify the microstructure of cartilage and subchondral bone in the medial tibial plateau. The results suggest that region-specific adaptations in subchondral bone are related to the severity of varus deformity, with subchondral sclerosis being most pronounced closer to the mechanical axis of the knee.
EUROPEAN CELLS & MATERIALS
(2023)
Meeting Abstract
Medicine, General & Internal
Valerio Luca Mainardi, Rubert Marina, Claudia Sabato, Anke De Leeuw, Chiara Arrigoni, Gabriele Dubini, Christian Candrian, Ralph Mueller, Matteo Moretti
SWISS MEDICAL WEEKLY
(2022)
Article
Materials Science, Biomaterials
Marija Vukomanovic, Lea Gazvoda, Nemanja Anicic, Marina Rubert, Danilo Suvorov, Ralph Muller, Sandra Hofmann
Summary: This study presents a novel multi-doped apatite material containing Mg2+, Sr2+, Zn2+ and Ga3+ ions, which shows good biocompatibility and antimicrobial activity while promoting bone regeneration.
BIOMATERIALS ADVANCES
(2022)
Article
Orthopedics
Mohammadjavad Einafshar, Ata Hashemi, Gerrit Harry van Lenthe
Summary: A non-destructive test method using modal analysis was proposed to evaluate the mechanical stability of pedicle screws. The natural frequency extracted from modal analysis was found to be linearly correlated with the insertion torque and pull-out force. The modal analysis was found to be a reliable and repeatable method for assessing the stability of implantable screws.
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
(2022)