Article
Endocrinology & Metabolism
Shejil Kumar, Ruby Chang, Michael Reyes, Terrence Diamond
Summary: This article reports a case of atypical femoral fracture in a post-menopausal Caucasian woman who had been using denosumab for osteoporosis for 5 years without prior bisphosphonate exposure. Although rare, physicians should consider the possibility of atypical femoral fracture in patients taking denosumab even without prior bisphosphonate exposure.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
M. K. Skjodt, M. T. Ernst, S. Khalid, C. Libanati, C. Cooper, A. Delmestri, K. H. Rubin, M. K. Javaid, D. Martinez-Laguna, E. Toth, D. Prieto-Alhambra, B. Abrahamsen
Summary: This study reveals a significant and persistent treatment gap in anti-osteoporosis treatment in patients aged 50 years and older who suffered major osteoporotic fractures in Denmark between 2005 and 2014, even with the inclusion of hospital-administered treatments. Strengthened post-fracture care organization and secondary fracture prevention are urgently needed.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Noa Bareli, Roni Gat, Victoria Makarov, Ethel Siris, Merav Fraenkel, Uri Yoel
Summary: Long-term use of bisphosphonates for osteoporosis may be associated with an increased risk of atypical femoral fractures, although the absolute risk remains low; Patients with atypical femoral fractures show better baseline medical conditions compared to those with typical hip fractures.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Chi Chiu Mok, Ling Yin Ho, Stella Mei Tik Leung, Hoi Ning Cheung, Sammy Pak Lam Chen, Kwok Man Ma
Summary: In patients receiving long-term glucocorticoids, denosumab was superior to alendronate in increasing spine bone mineral density after 12 months, with both drugs being well-tolerated.
Article
Endocrinology & Metabolism
P. V. -Q. Nguyen, M. Bouin, L. G. Ste-Marie
Summary: Oral bisphosphonates are effective in preventing fractures in osteoporosis patients, but may cause gastrointestinal adverse reactions. A study on hospitalized patients showed a similar incidence of upper gastrointestinal symptoms compared to community trials, indicating that these medications can be safely administered in a hospital setting.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Alexander J. Rodriguez, Nitesh Nerlekar, Peter R. Ebeling
Summary: This study investigated the cardiovascular safety of osteoporosis medications and found that oral and intravenous bisphosphonates have certain cardiovascular risks, while the cardiovascular safety of teriparatide is unclear.
Article
Endocrinology & Metabolism
Neil Binkley, Heenam Goel, Erin Shives, Diane Krueger, Kristyn Hare
Summary: This case report describes a probable atypical ulnar fracture associated with denosumab use in a male patient who was treated with teriparatide. The findings suggest that clinicians should be aware of the risk of atypical fractures with anti-resorptive therapy, particularly at non-femur sites.
Article
Medicine, General & Internal
Hong Jin Kim, Ha Kyun Chang, Dong-Gune Chang, JiYun Ha, Byeong-Rak Keum, Gun-Hwa Kim
Summary: This study aimed to analyze the incidence of bisphosphonate treatment failure, associated radiological factors, and effect of fracture healing in postmenopausal women with osteoporotic vertebral fractures. The non-response group had significantly lower initial BMD values than the response group, and the initial BMD value of the spine and the FRAX hip were identified as radiological factors influencing bisphosphonate non-response. These findings provide insights into the possible mechanisms and factors influencing bisphosphonate treatment failure in osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dennis M. Black, Katherine Condra, Annette L. Adams, Richard Eastell
Summary: Bisphosphonate use is associated with an increased risk of atypical femur fractures (AFFs), but it significantly reduces the risk of hip fractures and osteoporosis. The risk of AFFs varies between Asians and Caucasians, potentially due to differences in femoral geometry.
Article
Pharmacology & Pharmacy
Lauren E. Walker, Cyrus Cooper
Summary: Long-term use of bisphosphonates poses a risk of atypical femoral fractures, especially for those at low risk of fracture, therapy duration should be regularly assessed to ensure appropriate treatment duration.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Orthopedics
Youn Moo Heo, Sang Eun Park, Soo Min Cha, Hyun Dae Shin, Jae Kyu Choi
Summary: This study investigated 12 cases of atypical ulnar fractures in 10 patients and proposed diagnostic criteria and treatment algorithms. Atypical ulnar fractures were found to be related to prolonged bisphosphonate therapy and often occurred a few years after discontinuation. Plating was effective in treatment, but sclerotic bone resections and bone grafts may also be necessary.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Article
Endocrinology & Metabolism
Hiroki Iida, Yoshihito Sakai, Taisuke Seki, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Shiro Imagama
Summary: The study investigates the impact of bisphosphonate (BP) on mortality post osteoporotic vertebral fracture (OVF), and finds that BP medication is significantly associated with reduced all-cause mortality after OVF.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Engineering, Biomedical
Ani Ural
Summary: Antiresorptives, such as bisphosphonates and denosumab, effectively prevent osteoporotic fractures but long-term use may lead to rare atypical femoral fractures (AFF), causing patient anxiety and decreased prescription of osteoporosis treatment drugs. Current understanding of the pathogenesis of AFF is limited, with gaps in knowledge on the mechanical mechanisms underlying this condition.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Endocrinology & Metabolism
K. D. Gu, B. Ettinger, C. D. Grimsrud, J. C. Lo
Summary: This case report presents a patient with incomplete atypical femur fracture progression despite discontinuation of bisphosphonate treatment. Follow-up is important for patients with diaphyseal femur stress fractures, with potential for early healing with anabolic therapy. Managing older patients with incomplete AFF at risk for progression remains a challenge.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Zhangan Zheng, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, Liesbeth Vandenput, Enwu Liu, John A. Kanis, Eugene McCloskey
Summary: This study explores the relationship between nonsteroidal anti-inflammatory drugs (NSAIDs) and fracture risk and finds that the use of NSAIDs is associated with an increased risk of osteoporotic fractures. Furthermore, NSAIDs may diminish the efficacy of bisphosphonate treatment in reducing fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Joanna Kaluza, Shoko Komatsu, Mara Lauriola, Holly R. Harris, Leif Bergkvist, Karl Michaelsson, Alicja Wolk
Summary: The study found that high long-term consumption of non-fermented milk was associated with an increased risk of ER+/PR+ breast cancer, while high long-term consumption of fermented dairy products was associated with a decreased risk of ER-/PR- breast cancer. Furthermore, these risk associations were more pronounced in women with lower body weight.
CLINICAL NUTRITION
(2021)
Article
Orthopedics
Hans Peter Bogl, Georg Zdolsek, Karl Michaelsson, Jonas Hoijer, Jorg Schilcher
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2020)
Article
Medicine, General & Internal
Karl Michaelsson, John A. Baron, Liisa Byberg, Jonas Hoijer, Susanna C. Larsson, Bodil Svennblad, Hakan Melhus, Alicja Wolk, Eva Warensjo Lemming
Article
Surgery
Karin Bernhoff, Karl Michaelsson, Martin Bjorck
Summary: Arterial injuries in knee trauma are rare but can have devastating consequences if not promptly diagnosed. This study found that the incidence of arterial injury in knee trauma, particularly from knee dislocations, remains unclear. Falls and motor vehicle accidents were identified as common causes of arterial injury in knee trauma cases.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Adam Mitchell, Tove Fall, Hakan Melhus, Alicja Wolk, Karl Michaelsson, Liisa Byberg
Summary: The study found that the Mediterranean diet has a direct effect on the risk of hip fracture, independent of type 2 diabetes mellitus and body mass index. Mediation analysis showed that the indirect effects through type 2 diabetes or body mass index are minimal.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Shuai Yuan, Zi-Hao Wan, Shi-Le Cheng, Karl Michaelsson, Susanna C. Larsson
Summary: The study suggests that higher levels of circulating IGF-1 are associated with increased bone mineral density and reduced fracture risk. The positive association between IGF-1 and fracture persisted even after adjustment for bone mineral density, indicating a potentially independent role of IGF-1 in preventing fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Adam Mitchell, Susanna C. Larsson, Tove Fall, Hakan Melhus, Karl Michaelsson, Liisa Byberg
Summary: Observational studies have shown an association between type 2 diabetes mellitus and fasting glucose levels with hip fracture risk, bone area, and bone mineral density. Mendelian randomisation was used to investigate the causal relationship between fasting glucose levels and bone area and BMD in non-diabetic individuals. The results suggest that fasting glucose may be a causal risk factor for smaller bone area at the hip, but possibly for greater BMD as well, although further studies are needed to confirm these findings.
Article
Orthopedics
Nils P. Hailer, Ralf Kuja-Halkola, Anders Bruggemann, Nancy L. Pedersen, Karl Michaelsson
Summary: This study investigated the genetic susceptibility to hip and knee osteoarthritis necessitating total joint replacement, finding that heritability explained about half of the susceptibility on average, but varied with BMI and sex. Substantial heritability for knee replacement in obese women was demonstrated.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Endocrinology & Metabolism
Rui Zheng, Liisa Byberg, Susanna C. Larsson, Jonas Hoijer, John A. Baron, Karl Michaelsson
Summary: The study revealed that fracture risk is closely related to body composition, with higher baseline BMI and previous BMI gain inversely associated with all types of fractures, while higher baseline waist-to-height ratio was associated with hip fracture rates. After adjusting for BMD, higher baseline BMI, total lean mass index, fat mass index, and prior BMI gain were linked to increased fracture rates.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Karl Michaelsson, Liisa Byberg, Bodil Svennblad, Susanna C. Larsson, John A. Baron, Hakan Melhus
Summary: The study found that the association between serum 25-hydroxyvitamin D (S-25OHD) and fracture risk varies depending on season and fat mass. The relationship between low S-25OHD and fracture risk was only observed in women with high BMI during periods of seasonally high levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Adam Mitchell, Tove Fall, Hakan Melhus, Lars Lind, Karl Michaelsson, Liisa Byberg
Summary: The study revealed that individuals with incident type 2 diabetes mellitus (T2DM) had a lower expansion in bone area at the total hip compared to those without T2DM, while the change in bone area was similar between those with prevalent T2DM and those without the condition. Additionally, the study found slight differences in bone mineral density (BMD) changes between individuals with incident T2DM and those with prevalent T2DM compared to those without T2DM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Karl Michaelsson, Susanna C. Larsson
Summary: Recent cohort studies have shown a causal link between increased circulating alpha-tocopherol and greater bone mineral density, with no association with the odds of fractures. This suggests the need for intervention studies targeting individuals with low dietary intake of alpha-tocopherol, as well as Mendelian randomization studies focusing on fragility fractures as an outcome.
Article
Nutrition & Dietetics
Kia Nohr Iversen, Frida Carlsson, Agneta Andersson, Karl Michaelsson, Maud Langton, Ulf Riserus, Per M. Hellstrom, Rikard Landberg
Summary: Consuming high fiber rye products as part of a hypocaloric diet for 12 weeks led to greater weight loss, body fat reduction, and decrease in C-reactive protein compared to refined wheat products. However, no consistent differences were found between the two groups in terms of subjective appetite and other cardiometabolic risk markers.
CLINICAL NUTRITION ESPEN
(2021)
Article
Medicine, General & Internal
Madeleine Michaelsson, Shuai Yuan, Hakan Melhus, John A. Baron, Liisa Byberg, Susanna C. Larsson, Karl Michaelsson
Summary: This study used a bi-directional two-sample Mendelian randomization design to examine the relationships between ADHD, socioeconomic status, and intelligence. The results suggest that ADHD diagnosis could be a direct consequence of socioeconomic factors, independent of intelligence, while ADHD may lead to modestly lower socioeconomic status. Low intelligence does not seem to be a major independent cause or consequence of ADHD.
Article
Environmental Sciences
P. Monica Lind, Lars Lind, Samira Salihovic, Hakan Ahlstrom, Karl Michaelsson, Joel Kullberg, Robin Strand
Summary: According to this study, some PFAS are inversely related to fat mass, but not all PFAS show this relationship, and it mainly occurs in women.
ENVIRONMENTAL RESEARCH
(2022)