Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Endocrinology & Metabolism
Ying Liu, Hongbo Chen, Hui Li, Liman Li, Jin Wu, Hong Li
Summary: This meta-analysis found that metformin can significantly decrease HbA1c levels, BMI, and total daily insulin dose in adolescents with T1DM. However, it also increases the risk of hypoglycemia events and gastrointestinal adverse events. Further studies are needed to determine the optimal dosage and duration of metformin therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chin-Hsiao Tseng
Summary: Studies have shown a higher risk of gastric cancer in patients with diabetes mellitus, with those who have both conditions experiencing more complications and a poorer prognosis. However, glycemic control may improve in diabetes patients with gastric cancer following gastrectomy.
Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Review
Oncology
Hiroki Nishikawa, Shinya Fukunishi, Akira Asai, Keisuke Yokohama, Hideko Ohama, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in energy metabolism and glucose uptake. Conditions like type 2 diabetes, frailty, and aging can impact muscle health. Exercise and proper nutrition interventions are key in maintaining muscle health and preventing various diseases.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Amina Raza, Iftikhar Ahmed, Asher Fawwad, Fasiha Fatima, Ruqaya Nangrejo, Madiha Soban
Summary: This clinical trial found that the addition of metformin can decrease blood glucose and HbA1c levels in patients with type 1 diabetes, suggesting its potential role in improving diabetes control.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Catarina Chaves, Filipe Cunha, Mariana Martinho, Susana Garrido, Margarida Silva-Vieira, Catarina Estevinho, Anabela Melo, Odete Figueiredo, Ana Morgado, Maria Ceu Almeida, Margarida Almeida
Summary: The study found that women with gestational diabetes mellitus (GDM) treated with insulin plus metformin had similar obstetric and neonatal outcomes, as well as gestational weight gain and insulin dose, compared to those treated with insulin alone.
ACTA DIABETOLOGICA
(2021)
Review
Biochemistry & Molecular Biology
Santosh Kumar Singh, Tejumola Apata, Shriti Singh, Melayshia McFadden, Rajesh Singh
Summary: The association between diabetes mellitus and ovarian cancer has been supported by recent studies, with emerging evidence suggesting that metformin may have protective effects against ovarian cancer. Metformin exerts anti-cancer properties by activating the MAPK pathway, inhibiting the PI3K/AKT/mTOR pathway, and increasing tumor suppressor genes.
Review
Medicine, General & Internal
F. Frost, M. J. Walshaw, D. Nazareth
Summary: Cystic fibrosis (CF) is a common life-threatening inherited condition in the Caucasian population, with pulmonary disease being the main contributor to morbidity. While life expectancy has improved, new challenges have arisen, with an increasing prevalence of CF-related diabetes being a significant issue.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Tingting Cai, Yun Hu, Bo Ding, Rengna Yan, Bingli Liu, Ling Cai, Ting Jing, Lanlan Jiang, Xiaojing Xie, Yuming Wang, Huiying Wang, Yunting Zhou, Ke He, Lan Xu, Liang Chen, Cheng Cheng, Jianhua Ma
Summary: This study aimed to explore the chronic effects of metformin on testosterone levels in men with type 2 diabetes mellitus. The results showed that after 3-month treatment, testosterone levels decreased in the metformin group, especially total and free testosterone levels. In the subgroup with improved blood glucose, the control group had a significant increase in testosterone levels compared to the metformin group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Jing Lin, Rong-zu Tu, Xun-yu Hong
Summary: This study aims to evaluate the efficacy and safety of glyburide, metformin, and insulin in the treatment of GDM. Through systematic review and meta-analysis, relevant literature will be screened and analyzed, and the results will be submitted to a peer-reviewed journal. This meta-analysis will provide valuable information for healthcare practitioners and policy makers in managing GDM.
Article
Multidisciplinary Sciences
Rugang Li, Min He, Qilin Yang, Zezhi Liang, Ying li, Ling Huang, Rong Wu, Jieping Huang
Summary: This study explores the association between baseline serum creatinine level and new-onset type 2 diabetes in the Chinese population. The findings reveal that low serum creatinine is independently associated with an increased risk of type 2 diabetes among Chinese adults, and this association is consistent across different subgroups.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Maria J. Picon-Cesar, Maria Molina-Vega, Maria Suarez-Arana, Ernesto Gonzalez-Mesa, Ana P. Sola-Moyano, Reyes Roldan-Lopez, Francisca Romero-Narbona, Gabriel Olveira, Francisco J. Tinahones, Stella Gonzalez-Romero
Summary: This study demonstrated that metformin treatment for gestational diabetes achieved similar glycemic control as insulin, with better postprandial glycemic control, lower risk of hypoglycemic episodes, less maternal weight gain, and lower rate of cesarean deliveries. Most obstetrical and perinatal outcomes were similar between metformin and insulin-treated groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Chemistry, Medicinal
Alexander O. Shpakov
Summary: Metformin is widely used in the treatment of infertility and metabolic and endocrine disorders in both men and women, demonstrating positive effects on ovarian function, fetal development, pregnancy outcomes, and reproductive functions.
Review
Pharmacology & Pharmacy
Dorota Rogacka, Agnieszka Piwkowska
Summary: Podocytes and their foot processes are crucial for regulating glomerular permeability, with disturbances in podocyte function playing a central role in the development of proteinuria in diabetic nephropathy. Metformin, an oral antidiabetic agent, has potential beneficial effects on diabetic kidney function in addition to lowering glucose levels. Additionally, the activation of AMPK is a key mechanism of action of metformin in protecting against pathological changes in podocytes induced by hyperglycemia.
BIOCHEMICAL PHARMACOLOGY
(2021)