Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial ‘human osteoclastology’

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Role of Th17 cells in human autoimmune arthritis

(2010) Jan Leipe et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner

(2009) Leonard Rifas et al.   ARTHRITIS AND RHEUMATISM

Human osteoclastogenic T cells and human osteoclastology

(2009) Shigeru Kotake et al.   ARTHRITIS AND RHEUMATISM

T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis

(2009) Shigeru Kotake et al.   BONE

Human Th17 cells: Are they different from murine Th17 cells?

(2009) Francesco Annunziato et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-α antibody: A novel mechanism of osteoclastogenesis by IL-17

(2009) Toru Yago et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuki Nanke et al.   Modern Rheumatology

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

(2008) Steeve Kwan Tat et al.   BONE

Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet’s disease before ocular attack: a possible predictive marker of ocular attack

(2008) Yuki Nanke et al.   Modern Rheumatology