Article
Endocrinology & Metabolism
Christian Meier, Richard Eastell, Dominique D. Pierroz, Nancy E. Lane, Nasser Al-Daghri, Atsushi Suzuki, Nicola Napoli, Ambrish Mithal, Marlene Chakhtoura, Ghada El-Hajj Fuleihan, Serge Ferrari
Summary: This review provides a summary of current data on biochemical markers in relation to bone fragility and fracture risk in diabetes. The results show that although bone resorption and bone formation markers are not effective predictors of fracture risk in diabetes, osteoporosis drugs have similar effects on bone turnover markers in both diabetics and nondiabetics, resulting in reduced fracture risk. Other biochemical markers related to bone and glucose metabolism, such as sclerostin, glycated hemoglobin A(1c), and inflammatory markers, as well as hormones like insulin-like growth factor-1 and calciotropic hormones, are also associated with bone mineral density and fracture risk in diabetes. HbA(1c) levels appear to be the most reliable estimate of fracture risk, while bone turnover markers can be used to monitor the effects of antiosteoporosis therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Shannon Clare, Alexander Dash, Yi Liu, Jonathan Harrison, Katelyn Vlastaris, Seth Waldman, Robert Griffin, Paul Cooke, Vijay Vad, Ellen Casey, Richard S. Bockman, Joseph Lane, Donald McMahon, Emily M. Stein
Summary: This study investigated the acute changes in bone turnover following epidural steroid injections (ESIs) in postmenopausal women. Results showed a significant decrease in bone formation markers one week after ESI, which lasted for at least 12 weeks. Further investigation into the long-term skeletal consequences of these injections is warranted, considering the large population of older adults who receive ESIs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Sakda Arj-Ong Vallibhakara, Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, Orawin Vallibhakara
Summary: The study suggests that vitamin E (mixed-tocopherol) supplementation may have a preventive effect on bone loss in postmenopausal osteopenic women through anti-resorptive activity.
Article
Endocrinology & Metabolism
Ying Li, Qijun Cai, Chenchen Dong, Lu Hou, Yingxin Li, Bin Guo, Chunyuan Zeng, Yong Cheng, Jingjie Shang, Xueying Ling, Jian Gong, Hao Xu
Summary: This study examined bone turnover markers and hormones in cynomolgus monkeys at different ages. The results showed that female cynomolgus monkeys reached peak bone density at 10 years of age and maintained it until old age. Bone turnover markers peaked at 1 to 3 years of age and gradually decreased with age. Hormone levels did not significantly differ among age groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ian H. de Boer, Jye-Yu C. Backlund, Valerie Arends, Rose Gubitosi-Klug, Amisha Wallia, Naina Sinha Gregory, Annette Barnie, Andrew J. Burghardt, John M. Lachin, Barbara H. Braffett, Ann Schwartz
Summary: Poor glycemic control is associated with reduced bone formation in T1D patients, while reduced kidney function is associated with increased bone resorption and formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jakob Kau Starup-Linde, Rikke Viggers, Bente Langdahl, Soeren Gregersen, Simon Lykkeboe, Aase Handberg, Peter Vestergaard
Summary: Osteoglycin levels were similar in patients with type 1 and type 2 diabetes, and were not correlated with glucose, HbA1c, or any other biochemical marker of bone turnover. This suggests that there is no evidence supporting the existence of an osteoglycin-bone-pancreas axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaowei Jia, He Gong, Yingying Zhang, Hongmei Liu, Haipeng Cen, Rui Zhang, Yubo Fan
Summary: This study assessed and predicted femoral strength and its influencing factors in elderly men with type 2 diabetes mellitus (T2DM). The results showed that femoral strength was higher in the T2DM group, which may be caused by higher bone mineral density and lower bone turnover rate. In addition to bone density and bone formation level, advanced glycation end products (AGEs), blood glucose, and age may significantly impact the prediction of femoral strength in T2DM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Arkadiusz Zygmunt, Kinga Krawczyk-Rusiecka, Elzbieta Skowronska-Jozwiak, Katarzyna Wojciechowska-Durczynska, Ewa Glowacka, Zbigniew Adamczewski, Andrzej Lewinski
Summary: The study found that recombinant human TSH (rhTSH) has an impact on the concentrations of sclerostin and other bone markers, with a significant increase in TSH concentration leading to decreases in sclerostin, osteocalcin, and beta-CrossLaps levels. Additionally, baseline PTH, age, and creatinine concentrations can affect the degree of TSH increase.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Stergios Papachatzopoulos, Polyzois Makras, Athina Gkiomisi, Panagiotis Nikolakopoulos, Stergios A. Polyzos, Charikleia Ntenti, Iris Ballaouri, Spyridon Gerou, Olga Tsachouridou, Athanasios Papatheodorou, Konstantinos Aliazis, Sofia Fermanoglou, Ilias Bisbinas, Maria P. Yavropoulou
Summary: Goserelin-induced menstrual cessation leads to bone loss and changes in bone turnover and expression of bone-related miRNAs, which are only partially reversed six months after menstrual restoration.
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Orthopedics
Anna Matuszewska, Lukasz Matuszewski, Magdalena Jaszek, Pawel Polak, Szymon Stec
Summary: This study found that the use of bisphosphonate-enriched cement with Pamifos(R) after total knee arthroplasty can reduce the levels of bone turnover markers and cytokines, and may help to decrease the risk of osteoporotic fractures and aseptic revisions.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Pharmacology & Pharmacy
Qi Liu, Jian Zhou, Zhou Yang, Chuhai Xie, Yan Huang, Long Ling, Yanming Cao, Hailan Hu, Yue Hua
Summary: The study demonstrated that ginsenoside-Rb2 attenuates bone loss induced by KD and maintains biomechanical properties. This was achieved by inhibiting bone resorption and promoting osteogenic differentiation, suggesting ginsenoside as a potential option for KD-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Urszula Razny, Joanna Goralska, Philip C. Calder, Anna Gruca, Caroline E. Childs, Maria Kapusta, Krystyna Slowinska-Solnica, Aldona Dembinska-Kiec, Bogdan Solnica, Malgorzata Malczewska-Malec
Summary: Weight loss increases the risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation may mitigate the negative impact of weight loss on bone health, but the effect of fatty acids on bone health remains inconclusive.
Article
Nutrition & Dietetics
Laurent Maimoun, Safa Aouinti, Marion Puech, Patrick Lefebvre, Melanie Deloze, Pascal de Santa Barbara, Jean-Paul Cristol, Severine Brabant, Thomas Gautier, Marius Nedelcu, Eric Renard, Marie-Christine Picot, Denis Mariano-Goulart, David Nocca
Summary: Bariatric surgery leads to bone loss, and this study found that bone turnover increased following sleeve gastrectomy, resulting in reduced bone mineral density in the hip region.