Article
Multidisciplinary Sciences
Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama
Summary: Higher-intensity ultrasound and radial extracorporeal shock waves can accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation. Electrical stimulation does not affect the healing process.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tien-Ching Lee, Hui-Ting Chen, I-Chun Tai, Li-Ting Kao, Ming-Hsin Hung, Chung-Hwan Chen, Yin-Chih Fu, Yan-Hsiung Wang, Chih-Ming Kao, Je-Ken Chang, Mei-Ling Ho
Summary: The simvastatin derivative KMUHC-01 has been found to have a positive effect on promoting bone defect healing, with lower cytotoxicity compared to simvastatin. The new bone microstructure showed improved bone volume and biomechanical tests revealed increased maximal strength in the KMUHC-01 group. Further studies are needed to determine the bioavailability and bone-forming efficacy of KMUHC-01 through systemic administration.
Article
Biochemistry & Molecular Biology
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Enrico De Rose, Carlo Biz, Diego Guidolin, Raffaele De Caro, Carla Stecco
Summary: This study demonstrated for the first time that ESWs can lead to the in vitro production of hyaluronan-rich vesicles in fibroblasts derived from deep/muscular fascia, indicating their potential role in regulating and remodeling the extracellular matrix.
Article
Biochemistry & Molecular Biology
Po-Yen Chen, Jai-Hong Cheng, Zong-Sheng Wu, Yao-Chi Chuang
Summary: Shock waves have been widely applied in various fields of medical science. Low energy extracorporeal shock wave (LESW) therapy has been used in urology to treat diseases such as chronic prostatitis, and it enhances the expression of growth factors and inhibits inflammatory molecules, showing promise as an effective treatment method for various diseases.
Article
Medicine, General & Internal
I-Shen Huang, Wei-Jen Chen, Zhong-Lin Wang, Li-Hua Li, Yu-Kuang Chen, Yuh-Lin Wu, Robert E. Brannigan, Chi-Chang Juan, William J. Huang
Summary: This study aimed to evaluate the effect of shock wave treatment on spermatogenesis using different energy settings. The results showed that shock wave treatment significantly decreased sperm concentration, motility, and Johnsen score, while increasing the apoptotic index of spermatogenic cells. The expression of the SYCP3 gene also significantly changed after different intensity shock wave treatments.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Mechanics
Xiongbin Jia, Yong Xu, Hongtao Zheng, Huangwei Zhang
Summary: Two-dimensional simulations were conducted to study the direct initiation of cylindrical detonation in hydrogen/air mixtures with detailed chemistry. The effects of hotspot conditions and mixture composition gradient on detonation initiation were investigated. It was found that detonation initiation failed for low hotspot pressures, while high hotspot pressures led to the critical regime dominating. Detonation was directly initiated from the reactive hotspot, whereas ignition occurred beyond the non-reactive hotspots. Different cell diverging patterns were identified, and cell coalescence was observed when many irregular cells were generated initially.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hagai Hazan-Molina, Yankel Gabet, Itay Aizenbud, Nitzan Aizenbud, Dror Aizenbud
Summary: The study found that in a rat model, the addition of ESWT to orthodontic force after three weeks more than doubled the average tooth movement. ESWT application on the pressure side led to a significant decrease in volumetric bone mineral density. Blood vessel density and the number of TRAP positive cells increased after ESWT application.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Mechanics
Shibin Cao, Jiaao Hao, Igor Klioutchnikov, Herbert Olivier, Chih-Yung Wen
Summary: Direct numerical simulations are used to study hypersonic flow over a compression ramp, revealing the formation of streamwise heat flux streaks downstream of reattachment that exhibit low-frequency unsteadiness and are non-uniformly distributed in the spanwise direction. The unsteadiness of the heat flux streaks is coupled with a pulsation of the reattachment position, and global instabilities are found to be responsible for the flow unsteadiness.
JOURNAL OF FLUID MECHANICS
(2021)
Review
Biochemistry & Molecular Biology
Abdulmonem Alshihri
Summary: Extracorporeal shock wave therapy (ESWT) is a widely studied and applied technique in medical practice for various applications. It is gaining increasing interest in dental medicine due to its non-invasiveness, low cost, and safe qualities, as well as its proven regenerative biostimulating effects. However, successful ESWT treatment still requires careful consideration of targeted tissues and delivery parameters.
Article
Physics, Fluids & Plasmas
Rohtash Goyal, A. Sameen, T. Jayachandran, G. Rajesh
Summary: The study investigates the effect of rapid wedge rotation on the transition from regular to Mach reflection, comparing the unsteady shock reflection transition with the steady-state transition. Various flow features such as unsteady Mach stem height, reflection point position, and shock angle at the reflection point are compared for different wedge angles at fixed Mach numbers and rotation rates. The research also highlights the significant impact of the pivot point on Mach stem growth and the movement of the reflection point, especially at higher Mach numbers.
Article
Multidisciplinary Sciences
B. J. Sudhir, Anita Mahadevan, K. P. J. Reddy
Summary: Shock waves have been extensively researched for their traumatic effects on biological systems, but few research groups have successfully harnessed their power for therapeutic benefits. In neurosurgical applications, shock waves have been explored as a brain dissection tool, yet the challenges of controlling the effects of shock waves prevent their safe use in neurosurgery.
Review
Biochemistry & Molecular Biology
Tobias Wuerfel, Christoph Schmitz, Leon L. J. Jokinen
Summary: Extracorporeal shock wave therapy (ESWT) is a safe and effective treatment option for musculoskeletal disorders, but there is no consensus on its mechanism of action. Different tissues respond to shock waves in different ways, and the description of a mechanism does not guarantee its clinical relevance. Focused and radial shock waves seem to have similar effects. Optimum intensity, frequency, and localization of ESWT still require clinical research.
Article
Physics, Multidisciplinary
Kushal Seetharam, Yulia Shchadilova, Fabian Grusdt, Mikhail B. Zvonarev, Eugene Demler
Summary: This study explores the dynamics of a finite mass impurity injected into a three-dimensional quantum Bose fluid, revealing a transition in the dynamics as the impurity's velocity crosses a critical value. The two regimes differ not only in the character of the impurity velocity abatement, but also exhibit qualitative differences in various aspects such as the Loschmidt echo, density ripples, and momentum distribution of scattered bosonic particles. The transition, a manifestation of a dynamical quantum Cherenkov effect, could be experimentally observable with ultracold atoms using various techniques such as Ramsey interferometry and time-of-flight imaging.
PHYSICAL REVIEW LETTERS
(2021)
Article
Multidisciplinary Sciences
Mukhammad Kayumov, Dowan Kim, Sainath Raman, Graeme MacLaren, In Seok Jeong, Hwa Jin Cho
Summary: This study investigated the impact of ECMO on left ventricular hemodynamics in septic shock using a murine model. The results showed that ECMO in septic shock was associated with increased myocardial oxygen consumption.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Kang Lip Kim, Gi Young Park, Yong Suk Moon, Dong Rak Kwon
Summary: This study found that ESWT combined with PDRN injection was more effective in muscle regeneration than ESWT, PDRN injection alone, or normal saline injection on atrophied calf muscles in rabbit models.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Eline L. van der Veer, Willem Paul Gielis, Harry Weinans, Erik J. Beek, Peter M. van Hasselt, Ralph J. B. Sakkers
Summary: This study demonstrated that hip surgery in patients with mucopolysaccharidosis I can improve the sphericity of the femoral head, bringing it closer to normal hip characteristics. This provides valuable clinical evidence for treating flattened femoral heads caused by this disease.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Lizette Utomo, Niamh Fahy, Nicole Kops, Sandra T. van Tiel, Jan Waarsing, Jan A. N. Verhaar, Pieter J. M. Leenen, Gerjo J. V. M. van Osch, Yvonne M. Bastiaansen-Jenniskens
Summary: This study aimed to identify macrophage phenotypes in OA development using the DMM method in mice, and found that the presence of iNOS and CD206 in DMM knees were associated with synovial thickness, and CD163 staining inversely correlated with osteophyte presence. Additionally, differences in monocyte subset distribution in peripheral blood of DMM mice compared to sham mice were observed.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Kubo, Wolf Drescher, Athanassios Fragoulis, Mersedeh Tohidnezhad, Holger Jahr, Matthias Gatz, Arne Driessen, Jorg Eschweiler, Markus Tingart, Christoph Jan Wruck, Thomas Pufe
Summary: Osteonecrosis is a disease characterized by bone tissue death due to disturbance of the nutrient artery, with recent studies emphasizing the crucial role of oxidative stress in this process. However, current antioxidant monotherapy has not proven successful in preventing osteonecrosis in humans.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Materials Science, Multidisciplinary
Holger Jahr, Yageng Li, Jie Zhou, Amir A. Zadpoor, Kai-Uwe Schroeder
Summary: Absorbable porous metals manufactured by additive manufacturing offer customizable multi-scale geometries, interconnected porous structure, and tunable absorption properties for bone regeneration and remodeling. Thorough characterization of their biodegradation behavior, mechanical properties, and bone regeneration ability is essential for developing ideal implants. In comparison to solid inert counterparts, AM absorbable porous metals possess unique properties and potential, but face challenges in future Orthopedic solutions.
FRONTIERS IN MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Kubo, Rainer Beckmann, Athanassios Fragoulis, Claudius Conrads, Prathyusha Pavanram, Sven Nebelung, Michael Wolf, Christoph Jan Wruck, Holger Jahr, Thomas Pufe
Summary: Oxidative stress is associated with osteoarthritis, and the Nrf2/ARE signaling pathway controls SOX9 expression. Nrf2 directly regulates SOX9 in articular cartilage, and the loss of Nrf2 may lead to mild osteoarthritis in old age.
Article
Biochemistry & Molecular Biology
Holger Jahr, Anna E. van der Windt, Ufuk Tan Timur, Esther B. Baart, Wei-Shiung Lian, Bernd Rolauffs, Feng-Sheng Wang, Thomas Pufe
Summary: Increasing osmolarity to physiological levels promotes chondrogenic differentiation and marker expression in chondroprogenitor cells. The calcineurin inhibitor FK506 enhances this effect by modulating TGF-beta signaling at the type I receptor. Our findings provide insights into the mechanisms underlying cartilage repair strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Ruurd J. A. Kuiper, Ralph J. B. Sakkers, Marijn van Stralen, Vahid Arbabi, Max A. Viergever, Harrie Weinans, Peter R. Seevinck
Summary: Semantic segmentation of bone from lower extremity CT scans has been shown to be beneficial for visualization, diagnosis, and surgical planning in orthopaedics. In this study, the researchers developed a cascaded deep learning approach with a multi-stage V-net, which achieved accurate and fast segmentation of lower extremity bones. The method outperformed the state-of-the-art nnU-net in terms of training time, inference time, and GPU memory requirements. Morphometric measurements performed on the automatic segmentations showed good correlation with the manual segmentations. Overall, this approach showed promise for clinical applications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko
Summary: Osteoporosis and osteoarthritis are the leading causes of musculoskeletal dysfunction in older adults. Gut microbiota and metabolites play an important role in maintaining the homeostasis of cartilage and bone tissue. Modulating gut microbiota and supplementing microbiota-derived metabolites may help slow down the development of these skeletal disorders.
Article
Orthopedics
Joshua M. Bonsel, Lichelle Groot, Abigael Cohen, Jan A. N. Verhaar, Maaike G. J. Gademan, Anneke Spekenbrink-spooren, Gouke J. Bonsel, Max Reijman
Summary: During the COVID-19 lockdown, THA patients had slightly worse preoperative PROMs, indicating the selection of patients with greater urgency. Postoperative PROMs in both THA and TKA patients showed minimal differences, which were likely not clinically relevant overall.
Article
Cell Biology
Maximilian Koblenzer, Marek Weiler, Athanassios Fragoulis, Stephan Ruetten, Thomas Pufe, Holger Jahr
Summary: This study aimed to develop a bone mineralization model for more physiological high-throughput screenings. MC3T3-E1 pre-osteoblasts were cultured to form 3D spheroids, and the mineralization process was evaluated through gene expression, enzyme activity, and calcium deposition analyses. The established biomimetic model provides a versatile and cost-efficient tool for improved pharmacological ex vivo screenings.
Article
Surgery
B. A. T. D. van der Gronde, T. P. C. Schlosser, J. H. J. van Erp, T. E. Snijders, R. M. Castelein, H. Weinans, A. de Gast
Summary: This systematic review examined the relationship between sagittal spinopelvic characteristics and implant dislocations after primary THA. The study found that several sagittal spinopelvic patient characteristics were related to THA dislocations, and the associated risks were greater than for other patient and surgery-related factors. Further research is needed to determine which characteristics and parameters should be considered in patients undergoing primary THA.
Review
Biochemistry & Molecular Biology
Athanassios Fragoulis, Mersedeh Tohidnezhad, Yusuke Kubo, Christoph Jan Wruck, Rogerio Bastos Craveiro, Anna Bock, Michael Wolf, Thomas Pufe, Holger Jahr, Frank Suhr
Summary: Mechanosensing is crucial for maintaining tissue functions. Mechanical loading is necessary for the physiological functions of various tissues, while mechanical unloading can lead to pathological remodeling and dysfunctions. At the cellular level, both loading and unloading regulate cellular pathways, especially those involving oxidants like reactive oxygen species (ROS), which are essential for tissue organization and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Y. Li, P. Pavanram, J. Buehring, S. Ruetten, K-U. Schroeder, J. Zhou, T. Pufe, L. N. Wang, A. A. Zadpoor, H. Jahr
Summary: This study investigates the performance of AM porous iron by comparing its biodegradation behavior and cytocompatibility under static and dynamic conditions. The research finds that the biodegradation rate of AM porous iron significantly increases under in situ-like conditions, and its compatibility with various cell types is enhanced.
ACTA BIOMATERIALIA
(2023)
Article
Orthopedics
M. C. Koper, R. W. A. Spek, M. Reijman, E. M. van Es, S. J. Baart, J. A. N. Verhaar, P. K. Bos
Summary: The study aims to determine the correlation between increasing serum cobalt and chromium levels and decreasing Harris Hip Score (HHS) and Hip disability and Osteoarthritis Outcome Score (HOOS) in patients who received the Articular Surface Replacement (ASR) hip resurfacing arthroplasty (HRA), as well as evaluate the ten-year revision rate and the influence of sex, inclination angle, and Co level.
BONE & JOINT JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Kelly Warmink, Jaqueline L. Rios, Devin R. van Valkengoed, Nicoline M. Korthagen, Harrie Weinans
Summary: This study compares joint damage in different rat strains in response to a high-fat, high-sucrose diet. The results show that both rat strains have similar metabolic changes, but only Sprague Dawley rats experience a decrease in trabecular bone volume similar to osteoporosis. Osteophyte count and local joint inflammation are higher in Sprague Dawley rats, while cartilage degeneration and systemic inflammatory markers are similar between the rat strains. This suggests that the two rat strains may represent different joint damage phenotypes, potentially reflecting different phenotypes of osteoarthritis observed in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)