☆ 4.6 Article

Nonresectable Multiple Lung Metastases of High-Grade Osteosarcoma of the Humerus: Stable After Twelve Years

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2008)

Journal

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Volume 90A, Issue 10, Pages 2240-2244

Publisher

JOURNAL BONE JOINT SURGERY INC

DOI: 10.2106/JBJS.G.01619

Keywords

-

Categories

Orthopedics Surgery

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Oncology

Single-isocenter versus multiple-isocenters for multiple lung metastases: Evaluation of lung dose

Janita E. van Timmeren, Stefanie Ehrbar, Madalyne Chamberlain, Michael Mayinger, Mischa S. Hoogeman, Nicolaus Andratschke, Matthias Guckenberger, Stephanie Tanadini-Lang

Summary: A single-isocenter SBRT technique for lung patients with multiple targets results in clinically acceptable increases in normal lung dose.

RADIOTHERAPY AND ONCOLOGY (2022)

Add to Collection

Article Oncology

Differential gene expression analysis for osteosarcoma lung metastases

Fengsong Liu, Xiaojian Pang, Ziqi Yu, Kai Wang

Summary: This study explores the molecular mechanisms underlying lung metastases in osteosarcoma patients, identifying differentially expressed genes and miRNAs associated with the metastasis. The study also confirms the functions of these genes and miRNAs, providing a potential strategy for better understanding lung metastases in a clinical setting.

CANCER BIOMARKERS (2022)

Add to Collection

Article Medicine, General & Internal

Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival

Liyuan Tang, Binbin Liu

Summary: Osteosarcoma is a malignant tumor that rarely shows simultaneous lung and bone metastases. Factors such as female sex, tumor size, specific types of osteosarcoma, lymph node involvement, other metastatic sites, and treatments (surgery, radiotherapy, and chemotherapy) were significantly associated with lung metastases. Factors such as age, tumor stage, presence of lung metastases, liver metastases, and treatments were significantly associated with bone metastases. Both lung and bone metastases were significantly associated with specific types of osteosarcoma, tumor stage, other metastatic sites, and treatments. Metastases, radiotherapy, and surgery at the primary site were significantly correlated with lung and/or bone metastases. Chemotherapy at the primary site was effective in improving the survival rate of patients with lung and/or bone metastases. Older age, bone metastases, no surgery, and no chemotherapy were harmful to the survival of osteosarcoma patients with lung metastases. Similarly, in patients with bone metastases, factors such as lymph node involvement, no surgery, and no chemotherapy were harmful for survival. In patients with both lung and bone metastases, older age and no chemotherapy were harmful for survival.

MEDICINE (2023)

Add to Collection

Article Clinical Neurology

Comprehensive conservative treatment for multiple metastases of skull osteosarcoma: A case report

Dawei Jiang, Jingming Wang, Qian Chen, Junyi Wu, Ming Xu, Xiuchun Yu

Summary: This article reports a 16-year-old male patient with multiple metastases of skull osteosarcoma. After multiple conservative treatments, the patient's condition has stabilized and his quality of life has improved.

FRONTIERS IN NEUROLOGY (2023)

Add to Collection

Article Oncology

Radiomics Analysis of Multiparametric MRI for Prediction of Synchronous Lung Metastases in Osteosarcoma

Zhendong Luo, Jing Li, YuTing Liao, RengYi Liu, Xinping Shen, Weiguo Chen

Summary: This study established and validated a predictive model for predicting synchronous lung metastases in osteosarcoma using multiparameter MRI and clinical manifestations. The combined model showed good performance in predicting osteosarcoma SLM and may be helpful in clinical decision-making.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Review Cell Biology

Radiologic Assessment of Osteosarcoma Lung Metastases: State of the Art and Recent Advances

Anna Maria Chiesa, Paolo Spinnato, Marco Miceli, Giancarlo Facchini

Summary: The lung is the most common site of osteosarcoma metastases, with chest CT being the gold standard for detection but sensitivity varies. ESMO guidelines are important for follow-up, and new reconstruction techniques have reduced radiation dose. The use of FDG PET/CT is controversial, while VDT and CAD systems are emerging tools for lung nodule evaluation in osteosarcoma patients.

CELLS (2021)

Add to Collection

Article Orthopedics

Synchronous lung and multiple soft tissue metastases developed from osteosarcoma of tibia: a rare case report and genetic profile analysis

Chuanxi Zheng, Yitian Wang, Yi Luo, Zongguo Pang, Yong Zhou, Li Min, Chongqi Tu

Summary: This article reports a case of a young patient initially diagnosed with osteosarcoma of the right tibia and treated with standard chemotherapy and surgical resection. However, pulmonary metastases and multiple soft tissue masses in the skeletal muscle developed four years after the surgery. Genetic analysis revealed several novel variants in genes such as ALK, BLM, and PTCH1, expanding the mutational spectrum of osteosarcoma. These findings are important for understanding the clinical course and genetic characteristics of osteosarcoma patients with metastasis.

BMC MUSCULOSKELETAL DISORDERS (2022)

Add to Collection

Article Medicine, General & Internal

Lung metastases pattern in limb osteosarcoma A population-based study from 2010 to 2018

Binbin Liu, Liyuan Tang

Summary: Lung metastases are a significant concern for patients with limb osteosarcoma, and several factors, such as age, tumor size, and pathological type, are associated with this type of metastasis. Surgical treatment of the primary site can greatly improve the survival rate of these patients.

MEDICINE (2022)

Add to Collection

Article Oncology

Margin calculation for multiple lung metastases treated with single-isocenter SBRT

Janita E. van Timmeren, Mischa S. Hoogeman, Stefanie Ehrbar, Michael Mayinger, Nicolaus Andratschke, Matthias Guckenberger, Stephanie Tanadini-Lang

Summary: Relative inter-lesion position variation in single-isocenter SBRT is influenced by inter-target distance and location, and can be compensated with additional safety margins of less than 1 mm.

RADIOTHERAPY AND ONCOLOGY (2021)

Add to Collection

Article Oncology

Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors

Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante

Summary: A combination of high-energy carbon ion radiation therapy and checkpoint inhibitors shows significant effectiveness in reducing the growth of abscopal tumors in a murine model, with carbon ions being more efficient in reducing lung metastases compared to x-rays. The infiltration of immune cells in the abscopal tumors increased in animals treated with the combination therapy, suggesting a potential for effective treatment of advanced tumors with this approach.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

Hybrid Theater Facilitates Lung-Preserving Multimodal Treatment for Multiple Pulmonary Metastases

Peter S. Y. Yu, Cheuk-Man Chu, Rainbow W. H. Lau, Calvin S. H. Ng

Summary: This case demonstrates the successful treatment of multiple pulmonary metastases using microwave ablation in the hybrid theater. By combining various treatments, the lung metastases were effectively treated with adequate margin clearance, providing a unique choice for patients with concerns about lung function preservation.

ANNALS OF THORACIC SURGERY (2021)

Add to Collection

Article Gastroenterology & Hepatology

Outcomes of Stable Lung Colorectal Metastases on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Arnos Pantelis, Almog Ben-Yaacov, Mohammad Adileh, Gal Schtrechman, Einat Shacham-Shmueli, Ben Boursi, Ofer Margalit, Naama Halpern, Eyal Mor, Dan Assaf, Klug Maximiliano, Aviram Nissan, Shachar Laks

Summary: This study reviewed the outcomes of patients with CRPM who had stable lung metastases undergoing CRS/HIPEC, showing that the presence of stable lung metastases does not seem to affect the outcomes of CRS/HIPEC. Patients with stable lung disease should still be considered for CRS/HIPEC after multidisciplinary discussion.

JOURNAL OF GASTROINTESTINAL SURGERY (2022)

Add to Collection

Article Orthopedics

Skip metastases in high-grade intramedullary appendicular osteosarcoma: an indicator of more aggressive disease?

Asif Saifuddin, Maria Michelagnoli, Ian Pressney

Summary: The presence of skip metastases in high-grade appendicular osteosarcoma may indicate a more aggressive disease, as it is significantly associated with both lung and skeletal metastases, as well as poorer survival outcomes.

SKELETAL RADIOLOGY (2021)

Add to Collection

Article Oncology

Genetic and immune characteristics of multiple primary lung cancers and lung metastases

Ronghua Yang, Peng Li, Dong Wang, Lingjie Wang, Jihui Yin, Baohua Yu, Mengjun Li, Sai Wang, Yongjie Wang

Summary: IPM and MPLC show similar genetic and immune characteristics. The levels of CD56dim natural killer cells infiltration in the IPM group are significantly higher than in the MPLC group. Genomics alone may not effectively distinguish between IPM and MPLC, and comprehensive evaluation with clinical manifestations, imaging, and pathological characteristics is still needed.

THORACIC CANCER (2021)

Add to Collection

Article Multidisciplinary Sciences

Effect of whole-brain radiotherapy with platinum-based chemotherapy in non-small cell lung cancer patients with multiple metastases including brain metastases

Woo Kyung Ryu, Hyung Keun Cha, Woochul Kim, Ha Young Lee, Hyun-Jung Kim, Jeong-Seon Ryu, Jun Hyeok Lim

Summary: The combination of whole-brain radiotherapy (WBRT) with cytotoxic chemotherapy improved intracranial progression-free survival (iPFS) and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with EGFR, ALK, and PD-L1 negative status, an ECOG PS of 2, and multiple metastases including brain metastases.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Oncology

Lung metastasectomy for osteosarcoma in children, adolescents, and young adults: proof of permanent cure

Ugo Pastorino, Emanuela Palmerini, Luca Porcu, Roberto Luksch, Paolo Scanagatta, Cristina Meazza, Giovanni Leuzzi, Maura Massimino, Piero Picci

Summary: This study analyzed the clinical benefit and potential cure rate of repeated lung metastasectomy in a pediatric population. The results showed that repeated lung metastasectomy can achieve a permanent cure when offered to properly selected patients with metastases from osteosarcoma.

TUMORI JOURNAL (2023)

Add to Collection

Editorial Material Oncology

High-Risk Ewing Sarcoma: It Is Time to Break the Ceiling

Steven G. DuBois, Abha A. Gupta, Emanuela Palmerini

JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection

Article Oncology

Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)

David J. Barnes, Peter Dutton, Oyvind Bruland, Hans Gelderblom, Ade Faleti, Claudia Buhnemann, Annemiek van Maldegem, Hannah Johnson, Lisa Poulton, Sharon Love, Gesa Tiemeier, Els van Beelen, Karin Herbschleb, Caroline Haddon, Lucinda Billingham, Kevin Bradley, Stefano Ferrari, Emanuela Palmerini, Piero Picci, Uta Dirksen, Sandra J. Strauss, Pancras C. W. Hogendoorn, Emmeline Buddingh, Jean-Yves Blay, Anne Marie Cleton-Jansen, Andrew Bassim Hassan

Summary: This study reports a Bayesian designed phase II trial that investigates the efficacy of liposomal MTP-PE alone or in combination with ifosfamide in patients with metastatic and/or recurrent osteosarcoma. Despite poor recruitment and no objective responses, the study demonstrates the feasibility of the Bayesian design and the collection of tissue and serum samples for further analysis. Further investigation of liposomal MTP-PE in metastatic osteosarcoma is warranted.

BMC CANCER (2022)

Add to Collection

Review Oncology

Treatment updates on tenosynovial giant cell tumor

Emanuela Palmerini, Eric L. Staals

Summary: dt-TGCT impairs patients' quality of life. The understanding of its pathogenesis has changed the treatment options, with ongoing clinical trials targeting CSF1R. All this new evidence should be taken into consideration within multidisciplinary management.

CURRENT OPINION IN ONCOLOGY (2022)

Add to Collection

Article Oncology

CINSARC in high-risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG-STS 1001 study

Anna Maria Frezza, Silvia Stacchiotti, Frederic Chibon, Jean-Michelle Coindre, Antoine Italiano, Cleofe Romagnosa, Silvia Bague, Angelo Paolo Dei Tos, Luca Braglia, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin Broto, Antonio Lopez Pousa, Giovanni Grignani, Antonella Brunello, Jean-Yves Blay, Robert Diaz Beveridge, Iwona Lugowska, Tom Lesluyes, Roberta Maestro, Franco Domenico Merlo, Paolo Giovanni Casali, Alessandro Gronchi

Summary: The results of this study suggest that CINSARC has weak prognostic power in high-risk, localized soft tissue sarcoma patients.

CANCER MEDICINE (2023)

Add to Collection

Article Oncology

Bone Turnover Marker (BTM) Changes after Denosumab in Giant Cell Tumors of Bone (GCTB): A Phase II Trial Correlative Study

Emanuela Palmerini, Laura Pazzaglia, Luca Cevolani, Loredana Pratelli, Michela Pierini, Irene Quattrini, Elisa Carretta, Maria Cristina Manara, Michela Pasello, Giorgio Frega, Anna Paioli, Alessandra Longhi, Marilena Cesari, Rossella Hakim, Toni Ibrahim, Laura Campanacci, Eric Lodewijk Staals, Davide Maria Donati, Maria Serena Benassi, Katia Scotlandi, Stefano Ferrari

Summary: Denosumab treatment for GCTB patients reduces sBTMs levels, and high baseline s-CTX indicates a higher risk of disease progression.

CANCERS (2022)

Add to Collection

Review Oncology

Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments

Silvia Stacchiotti, Anna Maria Frezza, George D. Demetri, Jean-Yves Blay, Jyoti Bajpai, Giacomo G. Baldi, Elizabeth H. Baldini, Robert S. Benjamin, Sylvie Bonvalot, Judith V. M. G. Bovee, Dario Callegaro, Paolo G. Casali, Sandra P. D'Angelo, Elizabeth J. Davis, Angelo P. Dei Tos, Elizabeth G. Demicco, Jayesh Desai, Palma Dileo, Mikael Eriksson, Hans Gelderblom, Suzanne George, Rebecca A. Gladdy, Mrinal M. Gounder, Abha A. Gupta, Rick Haas, Andrea Hayes, Peter Hohenberger, Kevin B. Jones, Robin L. Jones, Bernd Kasper, Akira Kawai, David G. Kirsch, Eugenie S. Kleinerman, Axel Le Cesne, Roberta Maestro, Javier Martin Broto, Robert G. Maki, Aisha B. Miah, Emanuela Palmerini, Shreaskumar R. Patel, Chandrajit P. Raut, Albiruni R. A. Razak, Damon R. Reed, Piotr Rutkowski, Roberta G. Sanfilippo, Marta Sbaraglia, Inga-Marie Schaefer, Dirk C. Strauss, Sandra J. Strauss, William D. Tap, David M. Thomas, Annalisa Trama, Jonathan C. Trent, Winette T. A. van der Graaf, Winan J. van Houdt, Margaret von Mehren, Breelyn A. Wilky, Christopher D. M. Fletcher, Alessandro Gronchi, Rosalba Miceli, Andrew J. Wagner

Summary: This article discusses the minimum requirements for conducting retrospective observational studies (ROS) in ultra-rare sarcomas (URS) to improve their quality and effectiveness. An expert panel reached a consensus on a set of recommendations through a survey and discussion, covering the use of ROS results, selection of participating centers, diagnosis and assessment methods, consistency of data monitoring policies, and more.

CANCER TREATMENT REVIEWS (2022)

Add to Collection

Article Orthopedics

Pexidartinib Provides Modest Pain Relief in Patients With Tenosynovial Giant Cell Tumor: Results From ENLIVEN

John H. Healey, William D. Tap, Heather L. Gelhorn, Xin Ye, Rebecca M. Speck, Emanuela Palmerini, Silvia Stacchiotti, Jayesh Desai, Andrew J. Wagner, Thierry Alcindor, Kristen Ganjoo, Javier Martin-Broto, Qiang Wang, Dale Shuster, Hans Gelderblom, Michiel van de Sande

Summary: Pexidartinib provides modest pain reduction, slightly larger than the minimum clinically important difference (MCID), in patients with tenosynovial giant cell tumors (TGCT) not amenable to improvement with surgery，although it is not enough to justify its routine use for pain relief.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2023)

Add to Collection

Letter Oncology

Reply to DJ Benedetti et al

Steven G. DuBois, Abha A. Gupta, Emanuela Palmerini

JOURNAL OF CLINICAL ONCOLOGY (2023)

Add to Collection

Article Oncology

A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl)

Emanuela Palmerini, Marco Gambarotti, Antoine Italiano, Michael J. Nathenson, Ravin Ratan, Palma Dileo, Salvatore Provenzano, Robin L. Jones, Steven G. DuBois, Javier Martin-Broto, Enrique de Alava, Giacomo G. Baldi, Giovanni Grignani, Virginia Ferraresi, Antonella Brunello, Luca Paoluzzi, Rossella Bertulli, Nadia Hindi, Michael Montemurro, Christian Rothermundt, Stefania Cocchi, Carmen Salguero-Aranda, Davide Donati, Juan D. Martin, Amr H. Abdelhamid Ahmed, Alessandro Mazzocca, Elisa Carretta, Marilena Cesari, Michela Pierini, Alberto Righi, Marta Sbaraglia, Maria A. Laginestra, Katia Scotlandi, Angelo P. Dei Tos, Toni Ibrahim, Silvia Stacchiotti, Bruno Vincenzi

Summary: This study aimed to define the clinical characteristics, treatment, and outcome of undifferentiated small round cell sarcomas (URCSs) patients. The results showed significant differences in prognosis between URCS subtypes, and a full molecular assessment is needed to confirm the diagnosis. Prospective studies are needed to determine the optimal treatment strategy for each URCS subtype.

EUROPEAN JOURNAL OF CANCER (2023)

Add to Collection

Article Oncology

Tenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies

Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande

Summary: This article describes the impact of Tenosynovial giant cell tumor (D-TGCT) on patient-reported outcomes (PROs) based on the Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry. The study found that patients without active treatment strategy had lower pain levels and better quality of life at 1-year and 2-year follow-ups. On the other hand, patients receiving systemic treatment had higher pain levels when they changed treatment strategies. These findings highlight the significant impact of treatment strategies on patient quality of life.

ONCOLOGIST (2023)

Add to Collection

Article Oncology

Outcome of rare primary malignant bone sarcoma (RPMBS) treated with multimodal therapy: Results from the EUROpean Bone Over 40 Sarcoma Study (EURO-BOSS)

Emanuela Palmerini, Peter Reichardt, Kirsten Sundby Hall, Rossella Bertulli, Stefan S. Bielack, Alessandro Comandone, Gerlinde Egerer, Anna Hansmeier, Matthias Kevric, Elisa Carretta, Lina Hansson, Nina Jebsen, Mikael Eriksson, Oyvind S. Bruland, Davide Maria Donati, Toni Ibrahim, Sigbjorn Smeland, Stefano Ferrari

Summary: This study evaluated the treatment outcomes of European RPMBS patients, including local control and overall survival. Patients with localized disease and achieved surgical complete remission had higher 5-year overall survival rates. Therefore, using an osteosarcoma-like chemotherapy regimen may be a reasonable choice for RPMBS patients.

CANCER (2023)

Add to Collection

Article Oncology

Tenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies

Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande

Summary: This study investigated the impact of diffuse-type Tenosynovial giant cell tumor (D-TGCT) on treatment strategies and quality of life for patients. The results showed that patients who switched to an active treatment strategy had higher scores for pain and interference, while patients who remained off-treatment had lower scores at the 2-year follow-up. These findings are important for guiding the treatment and management of D-TGCT.

ONCOLOGIST (2023)

Add to Collection

Meeting Abstract Oncology

Prevalence of ultra-rare undifferentiated round cells sarcoma of bone and soft tissue after genomic classification.

Emanuela Palmerini, Alberto Righi, Marta Sbaraglia, Elisa Carretta, Angelo Paolo Dei Tos, GIovanna Magagnoli, Marilena Cesari, Anna Paioli, Alessandra Longhi, Rossella Hakim, Piero Picci, Margherita Maioli, Stefania Cocchi, Katia Scotlandi, Davide Maria Donati, Toni Ibrahim, Marco Gambarotti

JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection

Meeting Abstract Oncology

Spine high-grade osteosarcoma in the era of radiotherapy with high-energy charged particles: A single institution retrospective analysis.

Gisberto Evangelisti, Luigi Falzetti, Emanuela Palmerini, Marco Cianchetti, Joseph H. Schwab, Stefano Boriani, Toni Ibrahim, Alessandro Gasbarrini

JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.