Review
Biotechnology & Applied Microbiology
Alexander Malogolovkin, Alexander D. Egorov, Alexander Karabelsky, Roman A. Ivanov, Vladislav V. Verkhusha
Summary: Optogenetics, a technique that enables precise control of gene and cell activity using light, offers new possibilities for cancer treatment. By activating immune response, inhibiting tumor growth, and modulating cell signaling using specific wavelengths of light, optogenetics has the potential to revolutionize cancer therapy.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Pediatrics
Alessandra Cianflone, Fabio Savoia, Rosanna Parasole, Peppino Mirabelli
Summary: Including children in biomedical research requires ethical and legal reflection and improvement. Reconsent procedures and updating of data should be implemented as children grow. Standard operating procedures and collaboration with scientific networks are necessary for effective sharing of data and samples in pediatric research.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Editorial Material
Medicine, Research & Experimental
Tracey L. Weissgerber
Summary: Clinical Science proudly launches a new translational meta-research collection that applies the scientific method to study science itself. The collection aims to improve the quality and credibility of biomedical research by addressing issues such as transparency, rigor, and reproducibility through science of science studies.
Article
Chemistry, Physical
Maria J. C. Vilela, Bruno J. A. Colaco, Jose Ventura, Fernando J. M. Monteiro, Christiane L. Salgado
Summary: Designing biomaterials for bone-substitute applications remains a challenge due to the complex structure of hard tissues. This study aimed to scale up the production of a porous biocomposite scaffold for bone regeneration applications using a prototype bioreactor, showing reproducible properties relative to bench development and potential for commercialization. In vitro and in vivo tests demonstrated the scaffolds' ability to promote cell proliferation, osteogenic differentiation, tissue ingrowth, and defect filling, as well as non-cytotoxicity. The optimized production process successfully harnessed knowledge from basic sciences to enhance human health.
Review
Cell Biology
Ruin Moaddel, Ceereena Ubaida-Mohien, Toshiko Tanaka, Alexey Lyashkov, Nathan Basisty, Birgit Schilling, Richard D. Semba, Claudio Franceschi, Myriam Gorospe, Luigi Ferrucci
Summary: The identification of blood plasma proteins that change with age and predict health deterioration apart from chronological age is a growing research area. These proteins are important for understanding the mechanisms of aging and can potentially lead to the development of new treatments for improving health expectancy.
Article
Plant Sciences
Xiaohui Jiang, Weiyi Zhang, Alisdair R. Fernie, Weiwei Wen
Summary: Horticultural crops play a crucial role in providing nutrition, ornamental value, and medicinal benefits to human daily life. With the challenges posed by climate change and limited resources, breeding high-quality and adaptable horticultural crops becomes increasingly important to meet diverse human demands.
Review
Cardiac & Cardiovascular Systems
Gopika SenthilKumar, Cristhian A. Gutierrez-Huerta, Julie K. Freed, Andreas M. Beyer, Ibra S. Fancher, Amanda Jo LeBlanc
Summary: Microvascular disease is crucial in causing systemic end-organ dysfunction, and effective treatment can greatly reduce cardiovascular morbidity and mortality. This Call for Papers collection provides a concise summary of recent advances in translational microcirculatory research, focusing on the role of microvessels in chronic diseases and strategies to enhance microvascular function. The collection includes research articles, reviews, and therapeutic interventions, aiming to translate microcirculatory research from bench to bedside.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Health Care Sciences & Services
Seppe Segers, Elizabeth Chloe Romanis
Summary: This article examines the ethical implications of artificial womb technology, including improvements in conventional neonatal intensive care and prenatal interventions, as well as the broader socio-legal implications such as debates about abortion access and reproductive choices. The article also discusses the translational and societal issues in designing and developing this technology, and the legal and moral status of the entity gestating ex utero.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2022)
Review
Oncology
Elaine M. Thomas, Josephine A. Wright, Stephen J. Blake, Amanda J. Page, Daniel L. Worthley, Susan L. Woods
Summary: Colorectal cancer (CRC) is a prevalent and lethal disease, and immune checkpoint inhibitors (ICIs) have limited efficacy in most CRC patients. The most responsive patients are those with dMMR/MSI disease, but reliable predictors of ICI response are lacking. Development of novel mechanisms to increase response rates and prevent resistance is crucial. This review focuses on preclinical testing in CRC to inform the development of immuno-regulatory treatment strategies, with an emphasis on the shortcomings and advantages of commonly used mouse models.
BRITISH JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Sotirios A. Argyroudis, Stergios Aristotels Mitoulis, Eleni W. Chatzi, Jack W. Baker, Ioannis Brilakis, Konstantinos Gkoumas, Michalis Vousdoukas, William Hynes, Savina Carluccio, Oceane Keou, Dan M. Frangopol, Igor Linkov
Summary: Building climate-resilient infrastructure is crucial for economic prosperity and social cohesion, and emerging digital technologies have the potential to enhance this resilience. However, there are challenges and gaps that need to be addressed.
CLIMATE RISK MANAGEMENT
(2022)
Review
Genetics & Heredity
Hadley Stevens Smith, Kyle B. Brothers, Sara J. Knight, Sara L. Ackerman, Christine Rini, David L. Veenstra, Amy L. McGuire, Benjamin S. Wilfond, Janet Malek
Summary: The ambiguity in conceptualizing utility in translational genomics research can lead to communication challenges within research teams and study designs that do not meet stakeholder needs. By studying scholars' conceptual understanding of utility and term usage in different fields, researchers can increase clarity and cohesion in future research, helping to better integrate multidisciplinary investigations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Fei Xing, Hua-Mo Yin, Man Zhe, Ji-Chang Xie, Xin Duan, Jia-Zhuang Xu, Zhou Xiang, Zhong-Ming Li
Summary: This study demonstrates the fabrication of a 3D-printed PCL scaffold with a nanotopographical surface, loaded with urine-derived stem cells (USCs) for bone regeneration. The nanotopographical 3D-printed scaffold shows enhanced protein adsorption and mineralization ability, promotes the growth and gene expression of USCs, and exhibits good bone regeneration capability in cranial bone defects.
Article
Engineering, Biomedical
Vijay Shankar Kumawat, Sanchita Bandyopadhyay-Ghosh, Subrata Bandhu Ghosh
Summary: This article critically reviews the translational research on various engineered biomaterials for orthopaedic healthcare, aiming to bring transformative changes in bone repair. It discusses the composition and ultrastructure of bone, the global perspective on bone fracture surgeries, and the types, benefits, and challenges of natural and synthetic bone grafts. The article provides an overview of clinically relevant biomaterials, from traditionally used metallic, bioceramic, and biopolymeric biomaterials to new generation composites. It concludes with a discussion on the emerging trends and future perspectives of promising bone grafts.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Medicine, Research & Experimental
Chung-Sung Lee, Ginny Ching-Yun Hsu, Takashi Sono, Min Lee, Aaron W. James
Summary: By loading Hh signaling agonists into liposomes and immobilizing them onto trabecular bone-mimetic scaffolds, a significant increase in Hh-mediated osteogenic differentiation and bone healing was achieved. This approach showed more favorable outcomes compared to traditional treatment methods for bone repair.
MOLECULAR PHARMACEUTICS
(2021)
Article
Energy & Fuels
Osvalda Senneca, Francesca Cerciello
Summary: Predicting biomass combustion at temperatures of practical interest requires a robust and reliable kinetic expression. The present study examines experimental works on combustion kinetics of lignocellulosic biomass published since 2015 and reports the methods and parameters used. The variability of the parameters cannot be solely explained by feedstock heterogeneity or data analysis methods, indicating the complexity of biomass as a material. Conventional kinetic analysis methods may not be suitable, and expert-case sensitive approaches are recommended.
Article
Orthopedics
Shabnam Samsami, Robert Patzold, Tim Neuy, Markus Greinwald, Peter E. Muller, Yan Chevalier, Klaus Puschel, Peter Augat
Summary: This study compared the effects of two different double locked plating techniques on bicondylar tibial plateau fractures. The results showed that the location of the medial locking plate can affect the direction of movement for the fracture segments.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Emergency Medicine
Lisa Wenzel, Sabrina Sandriesser, Claudio Glowalla, Boyko Gueorguiev, Mario Perl, Fabian M. Stuby, Peter Augat, Sven Hungerer
Summary: The purpose of this study was to compare the stabilization of anterior column acetabular fractures fixed with a cranial socket revision cup with flange and iliac peg or with a suprapectineal plate osteosynthesis combined with an additional revision cup. Results showed that both surgical approaches showed comparable fracture reduction in terms of initial construct stiffness and interfragmentary movement. The potential benefit of the less-invasive cranial socket revision cup needs further investigation in clinical studies.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Neurosciences
Inga Kroeger, Janina Muessig, Andreas Brand, Robert Paetzold, Hannes Wackerle, Isabella Kloepfer-Kraemer, Peter Augat
Summary: Patients with surgically treated tibial shaft fractures show functional deficits during gait and squat performance even six months post surgery, with incomplete recovery in knee kinematics and kinetics when compared to healthy controls, explaining the reported functional limitations.
Article
Orthopedics
Sabrina Sandriesser, Katarina Ruehlicke, Peter Augat, Daniel Hensler
Summary: This study compares the effects of three different graft fixation positions on knee mobility and joint functionality in PCL reconstruction surgery. The results indicate that a lower graft fixation position within the femoral footprint of the PCL can restore knee stability and mobility.
Article
Veterinary Sciences
Johannes Maximilian Schmutterer, Peter Augat, Markus Greinwald, Andrea Meyer-Lindenberg
Summary: The study aimed to investigate changes in the stifle after a tibial plateau levelling osteotomy with different postoperative tibia plateau angles. Results showed that TPLO restored stifle kinematics and reduced the force acting on both menisci significantly after a 1-degree TPLO.
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Alexander Schuhmacher, Naomi Haefner, Katharina Honsberg, Jorg Goldhahn, Oliver Gassmann
Summary: Digital health and digital pharma are attractive markets for industry players, with Tech Giants such as Alphabet, Amazon, Apple, IBM, and Microsoft entering the healthcare and pharma industries. Through analysis of management models and public information, it is clear that these companies have built value propositions, value chains, and revenue models to revolutionize these industries and meet the needs of patients and healthcare providers.
DRUG DISCOVERY TODAY
(2023)
Article
Engineering, Biomedical
Thomas Thurner, Benjamin Esterer, David Fuerst, Marianne Hollensteiner, Sabrina Sandriesser, Peter Augat, Roland Pruckner, Daniela Wirthl, Martin Kaltenbrunner, Andreas Mueller, Gerhard Foerster, Claus Pototschnig, Andreas Schrempf
Summary: Surgical simulators are evolving educational tools for developing surgical skills, with virtual and hybrid simulators being preferred. A Smart Artificial Soft Tissue is presented to accelerate the revolution of hybrid simulators, providing objective positional feedback for haptically correct artificial soft tissue. The development of a laryngeal phantom demonstrates the capabilities of the simulator, which also uses a tablet computer for virtual representation and additional information display.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Critical Care Medicine
Dirk Stengel, Peter Augat, Peter V. Giannoudis
Summary: During the past decade, there has been an increase in large-scale pragmatic clinical trials in orthopedic trauma surgery. However, the precision of outcome measurement depends not only on sample size but also on the homogeneity of the studied population. There is currently a lively and controversial debate about the role of randomized controlled trials in the era of stratified medicine and the use of artificial intelligence in data analysis.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Critical Care Medicine
Christian von Rueden, Julia Rehme-Roehr, Peter Augat, Jan Friederichs, Simon Hackl, Fabian Stuby, Oliver Trapp
Summary: This review article summarizes the currently available evidence on the treatment of clavicle fractures. Classifications, indications, and treatment options for different fracture patterns of the medial, mid-shaft, and lateral clavicles are presented and discussed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Infectious Diseases
Noe Brasier, H. Ceren Ates, Juliane R. Sempionatto, Menino O. Cotta, Andreas F. Widmer, Jens Eckstein, Jorg Goldhahn, Jason A. Roberts, Wei Gao, Can Dincer
Summary: Bacterial antimicrobial resistance is a major cause of death worldwide, and therapeutic drug monitoring using wearable sensors can help mitigate this problem. Monitoring drug concentrations in non-invasively collectable biofluids can provide valuable information on the effectiveness of treatment at the site of infection.
LANCET INFECTIOUS DISEASES
(2023)
Article
Immunology
Ricards Marcinkevics, Pamuditha N. Silva, Anna-Katharina Hankele, Charlyn Doernte, Sarah Kadelka, Katharina Csik, Svenja Godbersen, Algera Goga, Lynn Hasenohrl, Pascale Hirschi, Hasan Kabakci, Mary P. LaPierre, Johanna Mayrhofer, Alexandra C. Title, Xuan Shu, Nouell Baiioud, Sandra Bernal, Laura Dassisti, Mara D. Saenz-de-Juano, Meret Schmidhauser, Giulia Silvestrelli, Simon Z. Ulbrich, Thea J. Ulbrich, Tamara Wyss, Daniel J. Stekhoven, Faisal S. Al-Quaddoomi, Shuqing Yu, Mascha Binder, Christoph Schultheiss, Claudia Zindel, Christoph Kolling, Jorg Goldhahn, Bahram Kasmapour Seighalani, Polina Zjablovskaja, Frank Hardung, Marc Schuster, Anne Richter, Yi-Ju Huang, Gereon Lauer, Herrad Baurmann, Jun Siong Low, Daniela Vaqueirinho, Sandra Jovic, Luca Piccoli, Sandra Ciesek, Julia E. Vogt, Federica Sallusto, Markus Stoffel, Susanne E. Ulbrich
Summary: In a study of 2,911 young adults, it was found that 65 individuals who had an asymptomatic or mildly symptomatic SARS-CoV-2 infection exhibited B and T cell responses, contributing to virus neutralization. The study suggests that next-generation COVID-19 vaccines should be designed to induce stronger cellular responses to sustain the generation of potent neutralizing antibodies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mischa Muehling, Sabrina Sandriesser, Claudio Glowalla, Sven Herrmann, Peter Augat, Sven Hungerer
Summary: Ipsilateral revision surgeries for total hip or knee arthroplasties are increasing due to aging population, and the risk of interprosthetic fractures depends on the distance between adjacent implants. This study investigated the strain within the femoral shaft between two implants using a physical model and finite element model. Results showed that a smaller interprosthetic distance and thinner cortices increased strain peaks, while a minimum interprosthetic distance of 10 mm seemed crucial to avoiding strain accumulation. Interprosthetic fracture management is especially important for patients with reduced bone quality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Carmela Niederberger, Arthur Vermeersch, Flavia Davidhi, Collin Y. Ewald, George Havenith, Joerg Goldhahn, Can Dincer, Noe Brasier
Summary: This article proposes a sweat-and wearable-based test to determine biological age, which is a real-time, noninvasive, and clinically applicable aging test in humans. This test would enable users to monitor their aging process and actively manage their lifestyle and health.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nadja A. Farshad-Amacker, Rahel A. Kubik-Huch, Christoph Kolling, Cornelia Leo, Jorg Goldhahn
Summary: This study compared the learning experience and performance of untrained operators in puncture of soft tissue lesions using augmented reality ultrasound (AR US) and standard ultrasound (sUS). The results showed that despite having no experience with AR, there was no significant difference in puncture time between AR US and sUS. However, students preferred using AR US for learning and performing ultrasound-guided biopsies, and a more favorable learning curve was achieved using AR US.
EUROPEAN RADIOLOGY
(2023)
Meeting Abstract
Orthopedics
N. Gerwin, C. Halleux, M. Fornaro, J. Elliott, Y. Zhang, S. Walter, G. Glowacki, K. Johnson, J. Shi, T. Peters, D. Laurent, J. Goldhahn, M. Schieker, C. Scotti, S. L. Brachat, R. Roubenoff, M. Kneissel
OSTEOARTHRITIS AND CARTILAGE
(2022)