Review
Veterinary Sciences
Yangli Pei, Chenghong Lin, Hua Li, Zheng Feng
Summary: This article provides an overview of the basic infection process, symptoms, immune mechanisms, noncoding RNA, and alternative splicing in PRRSV infection. It emphasizes the significant role of genetic background in susceptibility and resistance to PRRSV and its implications for individual treatment options.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Carissa A. Odland, Roy Edler, Noelle R. Noyes, Scott A. Dee, Joel Nerem, Peter R. Davies
Summary: A longitudinal study was conducted to assess the impact of different antimicrobial exposures of nursery-phase pigs on patterns of phenotypic antimicrobial resistance. Despite substantial differences in antimicrobial exposures, there were minimal differences observed between treatment groups and over time. The resistance patterns remained similar to those observed before any antimicrobial exposures, indicating the likely importance of factors other than antimicrobial exposure at the population level.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Peter Oba, Michel M. Dione, Joseph Erume, Barbara Wieland, Christine Mutisya, Linnet Ochieng, Elizabeth A. J. Cook, Frank N. Mwiine
Summary: This study identified the co-circulation of two species of PRRSv in northern Uganda. PRRSv showed an association with lung pathology, suggesting it may be a significant cause of lung disease in pigs in Uganda, leading to production losses. Further investigations are needed to assess the potential economic impacts of PRRSv on pig productivity, and discussions about surveillance and vaccination strategies in Uganda.
BMC VETERINARY RESEARCH
(2022)
Article
Microbiology
Wenli Zhang, Wenjie Ma, Yu Pan, Xinrong Wang, Mengjie Wang, He Zhang, Junxin Gao, Hongliang Zhang, Zhijun Tian, Changwen Li, Hongyan Chen, Changyou Xia, Yue Wang
Summary: In this study, the susceptibility of Rongchang pigs (a prominent local pig breed in China) to two different strains of PRRSV was investigated. The results showed that Rongchang pigs infected with HuN4 strain displayed significant clinical manifestations and pathological changes, while SD53-1603 infection caused less harm. Additionally, the two PRRSV strains elicited divergent cytokine responses and routine blood indices changes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Kiyoung Eun, Seon-Ung Hwang, Mirae Kim, Junchul David Yoon, Eunhye Kim, Hyerin Choi, Gahye Kim, Hee-Young Jeon, Jun-Kyum Kim, Jung Yun Kim, Nayoung Hong, Min-Gi Park, Junseok Jang, Hyeon Ju Jeong, Sung Jin Kim, Bong-Woo Ko, Sang Chul Lee, Hyunggee Kim, Sang-Hwan Hyun
Summary: In this study, a new onco-pig model was successfully developed using CRISPR-Cas9 technology, which exhibited cancer characteristics and could be used for cancer research. The results of the study indicate that this model has a wide range of potential applications.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Microbiology
Jessica Proctor, Iman Wolf, David Brodsky, Lizette M. Cortes, Alba Frias-De-Diego, Glen W. Almond, Elisa Crisci, Tatiane Terumi Negrao Watanabe, James M. Hammer, Tobias Kaeser
Summary: This study investigated the efficacy and immunogenicity of a modified live virus vaccine against four heterologous PRRSV-2 strains. The vaccine showed varying degrees of efficacy and immunogenicity, providing cross-protection and inducing a strong immune response and antibody production.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Qian Dong, Joan K. Lunney, Kyu-Sang Lim, Yet Nguyen, Andrew S. Hess, Hamid Beiki, Raymond R. R. Rowland, Kristen Walker, James M. Reecy, Christopher K. Tuggle, Jack C. M. Dekkers
Summary: The study reveals that different PRRSV isolates can induce different immune responses in tonsils of infected pigs at 42 days post infection, with pigs having higher viral levels showing larger immune cell enrichments. However, effects associated with viral levels and genotypes may not be significant after accounting for differences in cell composition.
BMC VETERINARY RESEARCH
(2021)
Review
Microbiology
Xin-xin Chen, Songlin Qiao, Rui Li, Jing Wang, Xuewu Li, Gaiping Zhang
Summary: By studying how PRRSV evades host immune responses, we can understand that the virus establishes long-term infection through various complex mechanisms, which is a major obstacle in controlling PRRS disease. Understanding the exact mechanisms of PRRSV immune evasion will contribute to the development of novel antiviral strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Giulia D'Annunzio, Fabio Ostanello, Luisa Vera Muscatello, Massimo Orioles, Niccolo Jacumin, Nicola Tommasini, Giorgio Leotti, Andrea Luppi, Luciana Mandrioli, Giuseppe Sarli
Summary: This study examines the impact of Porcine Circovirus type 2 (PCV2) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) on Porcine Respiratory Disease Complex (PRDC). The results show that PCV2 and PRRSV are the primary infections associated with PRDC in Italy, and co-infections can worsen the pathology. Therefore, selecting appropriate preventive measures is crucial.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Deling Jiao, Wenmin Cheng, Xiaolin Zhang, Yifan Zhang, Jianxiong Guo, Zhuo Li, Dejia Shi, Zhe Xiong, Yubo Qing, Muhammad Ameen Jamal, Kaixiang Xu, Hong-Ye Zhao, Hong-Jiang Wei
Summary: The study found that small PFFs with a diameter of less than 13 μm are more suitable donor cells for somatic cell nuclear transfer (SCNT) in pigs. Small cells exhibited better growth status and proliferation capabilities compared to medium and large cells, with medium and large cells showing various abnormalities such as cell membrane protuberance, karyo-pyknosis, autophagy, and mitochondrial abnormalities.
Article
Cell Biology
Chi-Hun Park, Young-Hee Jeoung, Luhui Zhang, Sai Goutham Reddy Yeddula, Ki-Eun Park, Jerel Waters, Bhanu P. P. Telugu
Summary: EFs derived from porcine embryonic outgrowths exhibit similarities to FFs. EFs can be used as nuclear donors in SCNT to enhance post-blastocyst development, implantation, and pregnancy outcomes, and as a source for CRISPR/Cas genome editing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Virology
Shengnan Ruan, Wenhui Ren, Bin Yu, Xuexiang Yu, Hao Wu, Wentao Li, Yunbo Jiang, Qigai He
Summary: In this study, a new TaqMan-based RT-qPCR assay was developed to detect and type the circulating PRRSV strains in Chinese swine populations. The assay showed high specificity, sensitivity, and concordance with reference assays, and could assist in monitoring PRRSV prevalence and implementing prevention and control strategies effectively.
Article
Immunology
Loic Vivien Bocard, Andrew Robert Kick, Corinne Hug, Heidi Erika Lisa Lischer, Tobias Kaser, Artur Summerfield
Summary: This study aimed to understand the nature of innate and adaptive immune responses to PRRSV, revealing differences in regulation by PRRSV-2 strains and MLV. Different PRRSV strains induced varied immune responses, impacting platelet activation, dendritic cell activity, interferon type I, and plasma cell responses. Correlations of BTMs with T-cell responses showed both positive and negative associations post-infection, indicating complexities in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Junliang Li, Dawei Yu, Jing Wang, Chongyang Li, Qingwei Wang, Weihua Du, Shanjiang Zhao, Yunwei Pang, Haisheng Hao, Xueming Zhao, Huabin Zhu, Shijie Li, Huiying Zou
Summary: This study investigates the imprinting status and methylation regulation of the DLK1-DIO3 region in wild-type and cloned neonatal pigs. The results reveal the abnormal imprinting and hypermethylation in the DLK1-DIO3 region in cloned pigs, providing a theoretical basis for improving cloning efficiency by gene editing to correct abnormal imprinting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Microbiology
Xiangbin You, Ying Lei, Ping Zhang, Dequan Xu, Zulfiqar Ahmed, Youbing Yang
Summary: PRRSV uses host transcription factors to escape the host immune system and create a favorable environment for replication. Understanding the role of host transcription factors is crucial for the treatment of PRRSV.
FRONTIERS IN MICROBIOLOGY
(2022)