Journal
JOURNAL OF BIOTECHNOLOGY
Volume 163, Issue 2, Pages 87-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2012.06.018
Keywords
Synthetic biology; Rational bioprocess engineering; Antibodies; Systems metabolic engineering
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Funding
- Collaborative Research Center From Gene to Product by the German Research Foundation (DFG) [SFB 578]
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The high industrial relevance of the soil bacterium Bacillus megaterium as host for recombinant proteins is driving systems-wide analyses of its metabolic and regulatory networks. The present review highlights novel systems biology tools available to unravel the various cellular components on the level of metabolic and regulatory networks. These provide a rational platform for systems metabolic engineering of B. megaterium. In line, a number of interesting studies have particularly focused on studying recombinant B. megaterium in its industrial bioprocess environment thus integrating systems metabolic engineering with systems biotechnology and providing the full picture toward optimal processes. (C) 2012 Elsevier B.V. All rights reserved.
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