Article
Hematology
Chieh-Lung Cheng, Chi-Yuan Yao, Po-Hao Huang, Chih-Wei Yu, Wei-Quan Fang, Wen-Hui Chuang, Shang-Ju Wu, Yu-Jen Lin, Yu-Chin Hung, Cheng-Hong Tsai, Shan-Chi Yu, Wen-Chien Chou, Hwei-Fang Tien
Summary: Hepatitis B is a common liver disease and chronic infection can lead to severe complications. Antiviral therapy is the main treatment method, but its effectiveness and safety still need improvement. Stem cell therapy may be a promising new strategy to help repair damaged liver cells.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Oncology
Jiayan Gu, Xin Huang, Yi Zhang, Chenhui Bao, Ziyang Zhou, Hongyan Tong, Jie Jin
Summary: This study evaluated the correlation between cerebrospinal fluid (CSF) cytokine levels and central nervous system (CNS) involvement in adult acute myeloid leukemia (AML). The results showed that CSF IL-6 is a promising marker for the diagnosis of adult AML with CNS involvement and is also associated with therapeutic response.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Xue Chen, Min Huang, Zhenyuan Zhang, Huilan Jing, Yueli Zou, Hui Bu
Summary: This article reports a rare case of primary meningeal central nervous system lymphoma. The patient presented with progressive lower extremity motor dysfunction and blurred vision. Diagnosis was confirmed through cytology, immunohistochemistry, and flow cytometry of the cerebrospinal fluid. After treatment, the patient showed significant improvement and could walk and take care of herself after a 2-year follow-up.
Article
Immunology
Arvid Eden, Frida Rydberg, Aylin Yilmaz, Lars Hagberg, Johanna Gostner, Staffan Nilsson, Dietmar Fuchs, Magnus Gisslen
Summary: For people with HIV initiating ART during chronic infection, the occurrence of residual CNS immune activation is not correlated with pretreatment immune status, even when treatment is initiated at high CD4(+) T-cell counts, suggesting that the CNS reservoir is not differentially affected by the timing of ART initiation during chronic infection.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medical Laboratory Technology
Yao Hu, Jin Xiang, Xiao Luo, Meijuan Lu, Dongwen Xu, Bobin Chen, Ming Guan
Summary: This study assessed the potential application of CSF FLC ratios in diagnosing PCNSL and monitoring treatment efficacy, and found that CSF FLC is a novel biomarker for diagnosis and chemotherapy efficacy monitoring in PCNSL.
CLINICA CHIMICA ACTA
(2022)
Letter
Clinical Neurology
Anand Kumar, Neha Lall
Summary: The study found that COVID-19 patients with neurologic symptoms had significant CSF inflammation, with raised soluble markers but no cellular response, unlike other viral CNS infections. Common CSF markers like neopterin and β2M are also elevated in various conditions, raising questions about their disease-specific value.
Article
Clinical Neurology
Velda X. Han, Shekeeb S. Mohammad, Hannah F. Jones, Sushil Bandodkar, Yanick J. Crow, Russell C. Dale
Summary: In the treatment of Aicardi-Goutières syndrome (AGS), Janus kinase (JAK) 1 inhibition shows a precision medicine approach targeting type I interferon-mediated cell signaling. Elevated cerebrospinal fluid (CSF) neopterin levels in AGS patients decreased significantly in response to JAK inhibitors, indicating a potential role for CSF neopterin as a biomarker of treatment response.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Medicine, General & Internal
Ji Hye Im, Tae Hoon Kim, Kyue-Yim Lee, Ho-Shin Gwak, Weiwei Lin, Jong Bae Park, Jong Heon Kim, Byong Chul Yoo, Seong-Min Park, Ji-Woong Kwon, Sang Hoon Shin, Heon Yoo
Summary: The study demonstrated the potential of extracellular microRNAs in cerebrospinal fluid as biomarkers for the diagnosis and pathogenesis study of leptomeningeal metastasis (LM). The unique miRNA profile in LM compared to brain metastasis (BM) suggests the importance of miRNAs in understanding LM pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Marzia Puccioni-Sohler, Samya J. da Silva, Luiz C. S. Faria, David C. B. I. Cabral, Mauro J. Cabral-Castro
Summary: This study aimed to evaluate neopterin and CXCL-10 in cerebrospinal fluid (CSF) for the diagnosis of neuroinvasive DENV and CHIKV, finding that CXCL-10 may be an accurate neuroinflammatory biomarker that contributes to the diagnosis of these two viruses.
Article
Immunology
Mathilde Labouret, Stefania Costi, Vincent Bondet, Vincent Trebossen, Enora Le Roux, Alexandra Ntorkou, Sophie Bartoli, Stephane Auvin, Brigitte Bader-Meunier, Veronique Baudouin, Olivier Corseri, Glory Dingulu, Camille Ducrocq, Cecile Dumaine, Monique Elmaleh, Nicole Fabien, Albert Faye, Isabelle Hau, Veronique Hentgen, Theresa Kwon, Ulrich Meinzer, Naim Ouldali, Cyrielle Parmentier, Marie Pouletty, Florence Renaldo, Isabelle Savioz, Flore Rozenberg, Marie-Louise Fremond, Alice Lepelley, Gillian I. Rice, Luis Seabra, Jean-Francois Benoist, Darragh Duffy, Yanick J. Crow, Pierre Ellul, Isabelle Melki
Summary: This study aimed to identify central nervous system (CNS) disease biomarkers of juvenile neuropsychiatric SLE (j-NPSLE). The results showed that cerebrospinal fluid (CSF) levels of neopterin and interferon-alpha (IFN-alpha) protein were significantly higher in active j-NPSLE cases with CNS involvement compared to j-SLE alone. These biomarkers could potentially be useful in the diagnosis and monitoring of j-NPSLE activity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Sromek, Grzegorz Rymkiewicz, Agnieszka Paziewska, Lukasz Michal Szafron, Maria Kulecka, Michalina Zajdel, Mariusz Kulinczak, Michalina Dabrowska, Aneta Balabas, Zbigniew Bystydzienski, Magdalena Chechlinska, Jan Konrad Siwicki
Summary: The diagnosis of primary central nervous system (CNS) lymphoma, particularly of the diffuse large B-cell lymphoma type (CNS DLBCL), is challenging. MicroRNAs (miRs) have the potential to serve as biomarkers for distinguishing between CNS DLBCL and non-malignant CNS diseases with tumor presentation (n-ML). Specific miR patterns were identified and a combination of four miRs showed high specificity and sensitivity in discriminating CNS DLBCL from n-ML samples.
Article
Pharmacology & Pharmacy
Keli Jaqueline Staudt, Bruna Bernar Dias, Izabel Almeida Alves, Benedicte Lelievre, Jean-Philippe Bouchara, Bibiana Verlindo de Araujo
Summary: This study developed a population pharmacokinetic model to describe the exposure of voriconazole in the plasma, interstitial cerebral fluid, and cerebrospinal fluid of rats. The model showed that voriconazole has sufficient tissue exposure in the interstitial fluid and cerebrospinal fluid for the treatment of fungal infections in these tissues.
Review
Immunology
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C. Dale, Shanlin Fu
Summary: CSF metabolomics has proven to be valuable in detecting neuroinflammation, with the ability to differentiate patients from controls. The potential of metabolomics in the diagnosis and treatment of neuroinflammatory diseases is increasingly evident.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Oncology
Yuki Yamagishi, Nobuyoshi Sasaki, Yoshiko Nakano, Yuko Matushita, Takaki Omura, Saki Shimizu, Kuniaki Saito, Keiichi Kobayashi, Yoshitaka Narita, Akihide Kondo, Yoshiaki Shiokawa, Motoo Nagane, Koichi Ichimura
Summary: The current standard for diagnosing CNS lymphoma is stereotactic biopsy, but it carries risks of complications. This study established a protocol for detecting MYD88 mutations in the CSF, showing that liquid biopsy with cfDNA is more accurate and efficient compared to cellular DNA. Digital PCR in cfDNA can effectively detect MYD88 L265P mutation, highlighting its importance in diagnosing CNS lymphoma.
Article
Clinical Neurology
Thiebaud Picart, Chloe Dumot, David Meyronet, Johan Pallud, Philippe Metellus, Sonia Zouaoui, Francois Ducray, Isabelle Pelissou-Guyotat, Moncef Berhouma, Luc Bauchet, Jacques Guyotat
Summary: This study investigated the occurrence of hydrocephalus in adult patients with cGB, finding that patients with hydrocephalus were younger and more likely to undergo tumor resection. Different cerebrospinal-fluid diversion options had comparable functional results and complication rates. Management strategies for postoperative hydrocephalus need to be carefully considered to avoid interfering with adjuvant oncological treatments.
NEUROSURGICAL REVIEW
(2022)
Article
Oncology
Alice Bonneville-Levard, Didier Frappaz, Olivier Tredan, Emilie Lavergne, Veronique Corset, Vincent Agrapart, Sylvie Chabaud, Daniel Pissaloux, Qing Wang, Valery Attignon, Stephanie Cartalat, Francois Ducray, Laure Thomas-Maisonneuve, Jerome Honnorat, David Meyronet, Luc Taillandier, Marie Blonski, Alain Viari, Christian Baudet, Emilie Sohier, Sylvie Lantuejoul, Sandrine Paindavoine, Isabelle Treilleux, Christine Rodriguez, David Perol, Jean-Yves Blay
Summary: Immunohistochemistry and recent molecular technologies have led to personalized anti-tumoral therapies for patients with advanced brain tumors. This study explored molecular profiling in these patients and identified actionable molecular alterations in some cases. However, only a small percentage of patients ultimately received molecular-based recommended therapy, with reasons including early death, lack of suitable clinical trials, or inappropriate results.
Article
Oncology
Matthias Preusser, Antonio Silvani, Emilie Le Rhun, Riccardo Soffietti, Giuseppe Lombardi, Juan Manuel Sepulveda, Petter Brandal, Lucy Brazil, Alice Bonneville-Levard, Veronique Lorgis, Elodie Vauleon, Jacoline Bromberg, Sara Erridge, Alison Cameron, Florence Lefranc, Paul M. Clement, Sarah Dumont, Marc Sanson, Charlotte Bronnimann, Carmen Balana, Niklas Thon, Joanne Lewis, Maximilian J. Mair, Philipp Sievers, Julia Furtner, Josef Pichler, Jordi Bruna, Francois Ducray, Jaap C. Reijneveld, Christian Mawrin, Martin Bendszus, Christine Marosi, Vassilis Golfinopoulos, Corneel Coens, Thierry Gorlia, Michael Weller, Felix Sahm, Wolfgang Wick
Summary: This randomized study on recurrent WHO grade 2 or 3 meningioma patients showed that intravenous trabectedin did not improve progression-free survival (PFS) and overall survival (OS) compared to local standard of care (LOC), and was associated with higher toxicity. Tumor DNA methylation class was identified as an independent prognostic factor for OS.
Article
Clinical Neurology
Alexandre Bani-Sadr, Marie-Camille Ruitton-Allinieu, Jean-Christophe Brisset, Francois Ducray, Bastien Joubert, Geraldine Picard, Francois Cotton
Summary: This study aimed to determine whether diffusion-weighted imaging (DWI) can help distinguish early-stage autoimmune (AI) encephalitis from herpes simplex virus (HSV) encephalitis. By comparing the MRIs of patients from a multi-center cohort of AI encephalitis and a single-center of HSV encephalitis, it was found that restricted diffusion lesions in the medial temporal lobe are a characteristic of HSV encephalitis and can aid in distinguishing it from early-stage AI encephalitis.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neurosciences
Hiroshi Mitoma, Kazuhiko Yamaguchi, Jerome Honnorat, Mario Manto
Summary: Long-term depression at parallel fibers-Purkinje cells (PF-PC LTD) is crucial for cerebellar motor learning and control. Dysregulation of PF-PC LTD has been identified as a factor in immune-mediated cerebellar ataxias and spinocerebellar ataxias, leading to impaired adaptive behaviors. LTDpathy is a clinical concept that encompasses these conditions characterized by PF-PC LTD dysfunction and related adaptive behavior impairments.
Article
Oncology
Antoine Seyve, Caroline Dehais, Olivier Chinot, Apolline Djelad, Elisabeth Cohen-Moyal, Charlotte Bronnimann, Carole Gourmelon, Evelyne Emery, Philippe Colin, Mathieu Boone, Elodie Vauleon, Olivier Langlois, Anna-Luisa Di Stefano, Romuald Seizeur, Francois Ghiringhelli, Anne D'Hombres, Loic Feuvret, Jacques Guyotat, Laurent Capelle, Catherine Carpentier, Louis Garnier, Jerome Honnorat, David Meyronet, Karima Mokhtari, Dominique Figarella-Branger, Francois Ducray
Summary: This study investigates the incidence and characteristics of pseudoprogression in isocitrate dehydrogenase-mutant high-grade gliomas (IDHmt HGG). It suggests that pseudoprogression is not only frequent but also frequently misdiagnosed in IDHmt HGG patients. The study highlights the importance of considering pseudoprogression within the first 2 years after radiotherapy.
Article
Clinical Neurology
Elise Peter, Le Duy Do, Salem Hannoun, Sergio Muniz-Castrillo, Alberto Vogrig, Valentin Wucher, Anne-Laurie Pinto, Naura Chounlamountri, Walaa Zakaria, Veronique Rogemond, Geraldine Picard, Julien-Jacques Hedou, Aditya Ambati, Agusti Alentorn, Alexandra Traverse-Glehen, Mario Manto, Dimitri Psimaras, Emmanuel Mignot, Francois Cotton, Virginie Desestret, Jerome Honnorat, Bastien Joubert
Summary: This study describes the clinical-immunologic features and long-term outcomes of patients with anti-DNER antibodies. Most patients had cerebellar ataxia and became moderately to severely disabled. Half of the patients improved, and younger age, milder clinical presentations, and less decrease of cerebellar gray matter volumes were associated with a better outcome.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Pathology
Thiebaud Picart, Delphine Poncet, Marc Barritault, Luc Bauchet, Sonia Zouaoui, Jacques Guyotat, Mathieu Gabut, Frederic Fina, Jerome Honnorat, Dominique Figarella-Branger, Johan Pallud, Francois Ducray, David Meyronet
Summary: The aim of this study was to identify subgroups of cerebellar glioblastoma (cGBM) based on targeted molecular analysis. Eighty-three cGBM cases were included and classified into 6 mutually exclusive subgroups associated with age at diagnosis and prognosis. MAPK pathway-activating alterations were found to be associated with a better outcome.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tam T. Quach, Harrison J. Stratton, Rajesh Khanna, Sabrina Mackey-Alfonso, Nicolas Deems, Jerome Honnorat, Kathrin Meyer, Anne-Marie Duchemin
Summary: This article provides an overview of neurodegenerative diseases and explores new therapeutic approaches. The accumulation of misfolded/aggregated proteins in the brain is a common pathological feature. The authors suggest a multiplexed gene transfer strategy to extend brain health span and improve chronic disease states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sebastien Durand, Marion Bruelle, Fleur Bourdelais, Bigitha Bennychen, Juliana Blin-Gonthier, Caroline Isaac, Aurelia Huyghe, Sylvie Martel, Antoine Seyve, Christophe Vanbelle, Annie Adrait, Yohann Coute, David Meyronet, Frederic Catez, Jean-Jacques Diaz, Fabrice Lavial, Emiliano P. Ricci, Francois Ducray, Mathieu Gabut
Summary: The study reveals that RSL24D1 is highly expressed in both mouse and human pluripotent stem cells and is involved in the biogenesis of 60S subunits. Depletion of RSL24D1 impairs global translation, particularly of pluripotency factors and components from the Polycomb Repressive Complex 2 (PRC2), leading to altered self-renewal and lineage commitment choices in embryonic stem cells.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Coline Montegut, Jean-Sebastien Guillamo, Francois Ducray, Caroline Dehais, Elisabeth Cohen-Jonathan Moyal, Christine Desenclos, Antoine Petit, Romuald Seizeur, Lien Bekaert, Claude Gaultier, Marie Jeannette Motuo Fotso, Marie Blonski, Jean-Sebastien Frenel, Elodie Vauleon, Olivier Langlois, Georges Noel, Antoine F. Carpentier, Anna Luisa Di Stefano, Charlotte Bronnimann, Dominique Figarella-Branger, Olivier Chinot, Emeline Tabouret
Summary: The study found that elderly IDH-mutated gliomas have similar characteristics to younger IDH-mutated gliomas but are significantly different from elderly IDH wild-type gliomas. The management of these elderly patients is suboptimal, with less frequent gross total resection and radiotherapy. An optimal therapeutic combination of radio-chemotherapy is safe and feasible for these elderly patients, and specific geriatric prognostic factors have been identified.
Review
Biochemistry & Molecular Biology
Agusti Alentorn, Giulia Berzero, Harry Alexopoulos, John Tzartos, German Reyes Botero, Andrea Morales Martinez, Sergio Muniz-Castrillo, Alberto Vogrig, Bastien Joubert, Francisco Garcia A. Jimenez, Dagoberto Cabrera, Jose Vladimir Tobon, Carolina Delgado, Patricio Sandoval, Monica Troncoso, Lorna Galleguillos, Marine Giry, Marion Benazra, Isaias Hernandez Verdin, Maelle Dade, Geraldine Picard, Veronique Rogemond, Nicolas Weiss, Marinos C. Dalakas, Pierre-Yves Boelle, Jean-Yves Delattre, Jerome Honnorat, Dimitri Psimaras
Summary: Anti-NMDAR encephalitis is associated with multiple antigenic triggers and this study aimed to explore if geographic and climatic factors may influence disease risk. Through a systematic review and meta-analysis, they found that the incidence of anti-NMDAR encephalitis varies among countries, with higher rates in Oceania and South America compared to Europe and North America. Regression models confirmed a strong negative correlation with latitude and seasonal analyses showed a peak of cases during warm months. Exposure-lag-response models revealed a positive correlation between extreme hot temperatures and disease incidence in France.
Review
Oncology
Andreas Bikfalvi, Cristine Alves da Costa, Tony Avril, Jean-Vianney Barnier, Luc Bauchet, Lucie Brisson, Pierre Francois Cartron, Helene Castel, Eric Chevet, Herve Chneiweiss, Anne Clavreul, Bruno Constantin, Valerie Coronas, Thomas Daubon, Monique Dontenwill, Francois Ducray, Natacha Entz-Werle, Dominique Figarella-Branger, Isabelle Fournier, Jean-Sebastien Frenel, Mathieu Gabut, Thierry Galli, Julie Gavard, Gilles Huberfeld, Jean-Philippe Hugnot, Ahmed Idbaih, Marie-Pierre Junier, Thomas Mathivet, Philippe Menei, David Meyronet, Celine Mirjolet, Fabrice Morin, Jean Mosser, Elisabeth Cohen-Jonathan Moyal, Veronique Rousseau, Michel Salzet, Marc Sanson, Giorgio Seano, Emeline Tabouret, Aurelie Tchoghandjian, Laurent Turchi, Francois M. Vallette, Somya Vats, Maite Verreault, Thierry Virolle
Summary: Glioblastoma (GBM) is a highly lethal brain tumor, and recent studies have emphasized the importance of the tumor microenvironment (TME) as a therapeutic target. However, a comprehensive understanding of the different cellular and molecular components involved in the GBM TME and their interactions is still needed for the development of more effective treatments. This review presents a comprehensive report on the GBM TME, combining the contributions of researchers and physicians in France, and provides a holistic view of the subject by describing the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.
Article
Chemistry, Multidisciplinary
Aikaterini Tsirkou, Flora Kaczorowski, Mathieu Verdurand, Rana Raffoul, Jonathan Pansieri, Isabelle Quadrio, Fabien Chauveau, Rodolphe Antoine
Summary: This work demonstrates the feasibility of nanospray-charge-detection-mass-spectrometry (CDMS) for amplifying alpha-synuclein fibrils from Parkinson's disease or Dementia with Lewy bodies patients, and its synergistic combination with RT-QuIC.
CHEMICAL COMMUNICATIONS
(2022)
Article
Clinical Neurology
Thiebaud Picart, Chloe Dumot, Jacques Guyotat, Vladislav Pavlov, Nathalie Streichenberger, Alexandre Vasiljevic, Tanguy Fenouil, Anne Durand, Emmanuel Jouanneau, Francois Ducray, Timothee Jacquesson, Moncef Berhouma, David Meyronet
Summary: Brain invasion was not considered as a criterion for atypical meningioma until 2016, and its assessment is crucial for predicting tumor progression. Collaboration between neurosurgeons and neuropathologists has strengthened the study of brain invasion in meningiomas.
NEUROSURGICAL REVIEW
(2022)
