Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 11, Pages 1892-1896Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.170325
Keywords
nerve regeneration; Rho/Rho-associated coiled-coil containing protein kinase; signaling pathway; axonal regeneration; central nervous system; microenvironment; reviews; NSFC grant; neural regeneration
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Funding
- National Natural Science Foundation of China [81471087, 81170577]
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The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore, a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system.
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