Journal
JOURNAL OF BIOTECHNOLOGY
Volume 133, Issue 2, Pages 208-212Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2007.08.019
Keywords
influenza virus; RNA polymerase; host factor; Ebp1
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The cellular protein Ebp1 was identified to interact with PB1 protein of influenza virus RNA polymerase, and inhibit both RNA synthesis in vitro and influenza virus replication in vivo [Honda, A., Okamoto, T., Ishihama, A., 2007. Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes Cells 12, 133-142]. The intracellular localization of Ebp1 that is involved in cell proliferation control was analyzed by direct immumostaining of cells before and after influenza virus infection. Ebp1 was found to localize in the nuclear membrane of uninfected cells, and to form nuclear aggregates with viral P proteins in virus-infected cells. (c) 2007 Elsevier B.V. All rights reserved.
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