Article
Multidisciplinary Sciences
Hirotaka Tsuno, Nobuho Tanaka, Masashi Naito, Satoru Ohashi, Mitsuyasu Iwasawa, Tomoyasu Kadoguchi, Hiroyuki Mitomi, Toshihiro Matsui, Hiroshi Furukawa, Naoshi Fukui
Summary: This study identified the proteins released from osteoarthritis (OA) cartilage by using antibody array analyses and a quantitative proteomic analysis. The results revealed that various biologically active proteins, including alarmins, complement proteins and angiogenic proteins, are released from degenerated areas of OA cartilage. These findings provide valuable insights into the pathology of OA.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Yang Liu, Chuanlei Zhang, Yanhui Kong, Huiyu Liu, Cheng Chen, Wenyu Gao, Xiaowei Xi, Hui Yang, Linhong Deng
Summary: Blindness often occurs due to corneal abnormalities, and corneal transplantation is the most effective treatment method. Developing high-quality artificial corneas is crucial since there is a shortage of available donor corneas for transplantation. Collagen, the main component of natural cornea, is commonly used as a material in corneal repair. However, promoting the regeneration of corneal nerves after surgery remains a challenge. In this study, researchers developed a novel collagen-based material that showed promising results in promoting the growth of nerve cells and corneal epithelial cells. The findings suggest that this material may have potential applications in cornea tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Rui Li, Jinghui Xu, Zilong Rao, Rongli Deng, Yiwei Xu, Shuai Qiu, Houqing Long, Qingtang Zhu, Xiaolin Liu, Ying Bai, Daping Quan
Summary: The decellarized matrix hydrogel derived from nerve tissue has shown effectiveness in promoting nerve reinnervation, remyelination, and functionalization. By incorporating vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) into the porcine decellularized nerve matrix hydrogel (pDNM-gel), both neovascularization and neuroregeneration were induced. The combination of VEGF and NGF in the pDNM-gel significantly facilitated motor functional recovery after peripheral nerve injury (PNI), highlighting the therapeutic promise of this approach for growth factor delivery towards neuroprotection and neuroregeneration.
TISSUE ENGINEERING PART A
(2021)
Review
Pharmacology & Pharmacy
Haniyeh Malektaj, Shirin Nour, Rana Imani, Mohammad H. Siadati
Summary: Cardiovascular diseases are the main cause of death globally. Inducing angiogenesis is considered crucial for supplying nutrients and oxygen to cells in cardiac tissue engineering. Different approaches, including biomaterials, drugs, angiogenic factors, and combinatorial methods, are summarized as potential platforms for effective cardiac tissue repair. Angiogenic induction can enhance patient treatment outcomes and generate economic prospects for the biomedical industry through collaboration between academic institutions, research organizations, and biomedical companies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Neurosciences
Zhiqian Ye, Junbin Wei, Chaoning Zhan, Jin Hou
Summary: Peripheral nerve injury is a common concern in trauma patients, and the outcome of repair surgeries can be unsatisfactory. Transforming growth factor-beta (TGF-beta), a multifunctional cytokine, plays a crucial role in peripheral nerve regeneration by enhancing nerve regrowth capacity. The potential of TGF-beta in promoting nerve regeneration is promising, providing new cues for better treatment of peripheral nerve injuries.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
X. Su, Y. Liu, O. ElKashty, J. Seuntjens, K. M. Yamada, S. D. Tran
Summary: This study investigated the potential of human bone marrow cell extract (BMCE) as a therapy for irradiation-induced salivary hypofunction. The results showed that BMCE, specifically the mononuclear cell extract (MCE) fraction, significantly increased salivary flow, preserved salivary gland cells, and promoted cell proliferation.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Youlu Chen, Zuoguan Chen, Jianwei Duan, Liang Gui, Huiyang Li, Xiaoyu Liang, Xinxin Tian, Kaijing Liu, Yongjun Li, Jing Yang
Summary: The research demonstrated that VEGF/NGF-NPs, by co-delivering VEGF and NGF genes, eliminating excessive H2O2, and promoting stable angiogenesis, enhanced the treatment effects of PVD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Jun Zhang, Yan Zhang, Yi Kun Jiang, Jian An Li, Wan Fu Wei, Ming Peng Shi, Yan Bing Wang, Guo Liang Jia
Summary: This study designed and tested a collagen-coated poly(lactic-co-glycolic acid) conduit loaded with CBD-IGF-1 for nerve regeneration. The conduit showed a rough surface and good hydrophilicity, and CBD-IGF-1 could be released slowly. In a rat sciatic nerve injury model, the group treated with the conduit showed the best sciatic functional index and electrophysiological parameters, along with better pathological examination results compared to the other groups.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Multidisciplinary
Haixing Xu, Yi Yu, Lingxi Zhang, Furong Zheng, Yixia Yin, Yuxiang Gao, Kebi Li, Jingyi Xu, Jing Wen, Hui Chen, Zhixin Lei, Zhijun Huang, Dan Yu, Nan Jiang, Peihu Xu
Summary: The study investigates the repair of injured peripheral nerves in rats using PDLLA/beta-TCP nerve conduits laden with CS-HA/NGF hydrogels, showing that the hydrogels promote adhesion, spreading, and differentiation of neuronal cells while sustaining NGF release. In vivo studies demonstrate a significant positive effect on axon regeneration and myelination compared to control groups, indicating the potential of CS-HA/NGF injectable hydrogel in promoting nerve regeneration in neural tissue engineering.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Yuhe Zhu, Nanjue Cao, Yue Zhang, Guangxiu Cao, Chunping Hao, Keda Liu, Xiaoming Li, Wei Wang
Summary: This study combined concentrated growth factor (CGF) with nano-hydroxyapatite/collagen (nHAC) to repair rabbit mandibular defects. The results showed that the nHAC/CGF material promoted new bone formation and exhibited superior bone continuity, maturity, and biomechanical properties compared to nHAC alone. These findings provide new insights for the application of bone tissue engineering scaffold materials in oral clinics.
Article
Ophthalmology
Qianwen Gong, Shasha Zhang, Lu Jiang, Meng Lin, Zhiqiang Xu, Ye Yu, Qinmei Wang, Fan Lu, Liang Hu
Summary: This study compared the effects of nerve growth factor (NGF), hycosan, and normal saline (NS) treatments on dry eye symptoms following LASIK surgery. The results showed that NGF treatment significantly accelerated corneal nerve regeneration and recovery of sensitivity, outperforming hycosan and NS treatments. Additionally, NGF treatment improved tear breakup time and increased nerve fiber quantity compared to the other treatments.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Engineering, Biomedical
Yuting Cai, Qun Huang, Penghui Wang, Kaichuang Ye, Zhen Zhao, Haomin Chen, Zhenjing Liu, Hongwei Liu, Hoilun Wong, Mohsen Tamtaji, Kenan Zhang, Feng Xu, Guorui Jin, Lun Zeng, Jianbo Xie, Yucong Du, Zhigang Hu, Dazhi Sun, Jinbao Qin, Xinwu Lu, Zhengtang Luo
Summary: This study develops a graphene-based nerve guidance conduit for diabetic patients with peripheral nerve injury. The conduit incorporates a natural double network hydrogel and a neurotrophic concentration gradient, providing good biocompatibility and sustained growth factor release. The graphene mesh improves the toughness and conductivity of the conduit, promoting regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Arpan Satsangi, Sudipa S. Roy, Rajiv K. Satsangi, Anthony W. Tolcher, Ratna K. Vadlamudi, Beth Goins, Joo L. Ong
Article
Engineering, Biomedical
Lisa Actis, Anand Srinivasan, Jose L. Lopez-Ribot, Anand K. Ramasubramanian, Joo L. Ong
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2015)
Article
Cell & Tissue Engineering
Bin-Xian Zhang, Zhi-Liang Zhang, Alan L. Lin, Hanzhou Wang, Marcello Pilia, Joo L. Ong, David D. Dean, Xiao-Dong Chen, Chih-Ko Yeh
TISSUE ENGINEERING PART A
(2015)
Editorial Material
Biotechnology & Applied Microbiology
Kazuhisa Bessho, Joo L. Ong, Norbert R. Kuebler, John G. Clement
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Materials Science, Biomaterials
John W. Durham, Sergio A. Montelongo, Joo L. Ong, Teja Guda, Matthew J. Allen, Afsaneh Rabiei
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Pharmacology & Pharmacy
Neda Habibi, Laura Pastorino, Ghazal Babolmorad, Carmelina Ruggiero, Teja Guda, Joo L. Ong
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2017)
Review
Materials Science, Multidisciplinary
Rohit Khanna, Joo L. Ong, Ebru Oral, Roger J. Narayan
Article
Engineering, Biomedical
Teja Guda, John A. Walker, Brian Singleton, Jesus Hernandez, Daniel S. Oh, Mark R. Appleford, Joo L. Ong, Joseph C. Wenke
JOURNAL OF BIOMATERIALS APPLICATIONS
(2014)
Article
Engineering, Biomedical
C. R. Rathbone, T. Guda, B. M. Singleton, D. S. Oh, M. R. Appleford, J. L. Ong, J. C. Wenke
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2014)
Article
Cell & Tissue Engineering
Ramon E. Coronado, Maria Somaraki-Cormier, Joo L. Ong, Glenn A. Halff
STEM CELL RESEARCH
(2019)
Article
Engineering, Biomedical
Solaleh Miar, Cynthia A. Perez, Joo L. Ong, Teja Guda
JOURNAL OF BIOMATERIALS APPLICATIONS
(2019)
Article
Engineering, Biomedical
Joseph J. Pearson, Nicholas Gerken, Chunsik Bae, Kyu-Bok Lee, Arpan Satsangi, Sean McBride, Mark R. Appleford, David D. Dean, Jeffrey O. Hollinger, Joo L. Ong, Teja Guda
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Cell & Tissue Engineering
Ramon E. Coronado, Maria Somaraki-Cormier, Shanmugasundaram Natesan, Robert J. Christy, Joo L. Ong, Glenn A. Halff
CELL TRANSPLANTATION
(2017)
Review
Dentistry, Oral Surgery & Medicine
Laura Gaviria, Joseph J. Pearson, Sergio A. Montelongo, Teja Guda, Joo L. Ong
JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS
(2017)