Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 5, Pages 766-771Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.157243
Keywords
nerve regeneration; brain injury; neuroprotection; cerebral ischemia/reperfusion injury; lateral intracerebroventricular injection; Apelin-13; nerve apoptosis; Bcl-2; caspase-3; NSFC grants; neural regeneration
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Funding
- National Natural Science Foundation of China [30971081, 31271243, 81070961, 81241052]
- Natural Science Foundation of Shandong Province of China [ZR2011CM027, 2012GGA08100]
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Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide, yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied. In this study, Apelin-13 (0.1 mu g/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats. TTC, TUNEL, and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group, infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group. Additionally, Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity. Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.
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