Article
Pharmacology & Pharmacy
Solen Novello, Sylvie Tricot-Doleux, Agnes Novella, Pascal Pellen-Mussi, Sylvie Jeanne
Summary: This study evaluated the influence of periodontal ligament stem cell-derived conditioned medium (CM) on osteoblasts and its potential as a therapeutic tool for periodontal regeneration. The findings showed that PDLSC-CM enhanced osteoblast proliferation and increased the expression of some osteoblastic differentiation markers.
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Toshihide Mizoguchi, Noriaki Ono
Summary: Osteoblasts are the only cells capable of forming bones in vertebrates, with their main function being the production of mineralized matrix. Disruption of their regulation can lead to various bone diseases, highlighting the importance of understanding the origin of these cells for the development of novel therapeutic approaches. Recent advances in technology have provided new insights into the diverse sources of osteoblasts involved in bone formation under different conditions.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Polymer Science
Chong Teng, Zhicheng Tong, Qiulin He, Huangrong Zhu, Lu Wang, Xianzhu Zhang, Wei Wei
Summary: In this study, biocompatible hydrogel microspheres were fabricated to promote the osteogenic differentiation of stem cells and enhance bone regeneration. The results from in vivo experiments demonstrated the superiority of the BMSC/HM system in inducing bone regeneration. This study provides a simple and effective research idea for bone defect repair, and the optimization of hydrogel microspheres holds promise for future tissue engineering applications.
Article
Cell Biology
Maria Norte-Munoz, Fernando Lucas-Ruiz, Alejandro Gallego-Ortega, David Garcia-Bernal, Francisco J. Valiente-Soriano, Pedro de la Villa, Manuel Vidal-Sanz, Marta Agudo-Barriuso
Summary: The study examines the impact of different types of transplants on neuroprotection and axonal regeneration, finding that syngrafts significantly influence the survival and regeneration of neurons and axons, while xenografts may lead to retinal issues and allografts have limited effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Noy Pinto, Yehuda Klein, Eilon David, David Polak, Daniel Steinberg, Gilad Mizrahi, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu
Summary: In this study, the effect of endogenous lipid RvD1 on allograft osteointegration in alveolar bone regeneration was investigated. Repeated administrations of RvD1 were found to promote bone regeneration through enhancing osteoblasts' differentiation and reducing osteoclastogenesis. This suggests that RvD1 may be a potential therapeutic bioagent for osseous regeneration following allograft implantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Feng Wang, Wenbo Wang, Lingchi Kong, Li Shi, Mengwei Wang, Yimin Chai, Jia Xu, Qinglin Kang
Summary: This study found that ADM2 accelerates bone regeneration by enhancing the osteogenic differentiation and pro-angiogenic potential of BMSCs, possibly through the NF-κB/β-catenin and AKT/β-catenin pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Izumi Asahina, Hideaki Kagami, Hideki Agata, Masaki J. Honda, Yoshinori Sumita, Minoru Inoue, Tokiko Nagamura-Inoue, Arinobu Tojo
Summary: This study evaluated the safety and efficacy of bone tissue engineering using BMSCs in patients with severe atrophic alveolar bone. The results showed good long-term stability and safety of the regenerated bone, suggesting potential application in clinical practice. However, individual variations were observed, highlighting the need for further studies with larger sample sizes to confirm the efficacy of BMSCs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Jie Liang, Wenhua Li, Ning Zhuang, Sini Wen, Shijia Huang, Weizhi Lu, Yezhen Zhou, Gaozu Liao, Bao Zhang, Chenglong Liu
Summary: The new photosensitive material g-C3N4/rGO can promote the proliferation and differentiation of BMSCs under natural light irradiation, accelerating bone regeneration and repair. Results showed that the blue light material group exhibited better osteogenesis compared to the light-shielding material group, and animal experiments confirmed the significantly higher bone repair potential of the material group.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Health Care Sciences & Services
Cheng-Feng Chu, Shih-Hsuan Mao, Victor Bong-Hang Shyu, Chih-Hao Chen, Chien-Tzung Chen
Summary: The study found that allogeneic BMSCs can promote bone regeneration to some extent and gradually match the efficacy of autologous BMSCs after a period of time. In terms of immune response, allogeneic BMSCs caused a weaker immune response in vivo and the bone regeneration effects gradually matched those of autologous BMSCs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Paulina Kazimierczak, Malgorzata Koziol, Agata Przekora
Summary: The newly developed biomaterial showed high biocompatibility and influenced macrophage polarization and osteoblast differentiation, playing an immunomodulatory role. The study demonstrated a low risk of inflammatory response and induced macrophage polarization into the osteogenic phenotype M2, making it a promising bone scaffold for regenerative medicine applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aoi Ikedo, Yuuki Imai
Summary: Estrogen deficiency impairs fracture healing by affecting the expression ratio of estrogen receptors, especially ERα, in callus during the process. The study clarified the significance of ERs during fracture healing using osteoblast-specific ER knockout mice, showing that ERα in osteocalcin-positive osteoblasts may contribute to the late stage of bone regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Tingting Yang, Yunsheng Dong, Jinpeng Wan, Xiangsheng Liu, Yufei Liu, Jiaxing Huang, Jie Zhou, Hui Xiao, Lizong Tang, Yanying Wang, Shufang Wang, Hong Cai
Summary: This study investigated the effect of the diabetic microenvironment on extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs). It was found that EVs secreted under high glucose conditions had weaker functions compared to those secreted under normal glucose conditions. Therefore, autologous EVs from diabetic patients are not suitable for self-repair. A 3D printing scaffold for sustained-release EVs was developed as a new strategy for acellular tissue engineering bone repair in diabetic patients.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biophysics
Zimo Zhou, Da Liu
Summary: Porous tantalum-based biomaterials have been widely used in bone defect repair due to their unique properties and excellent biocompatibility. BMSCs, as an important type of stem cells, have shown great potential in regulating the effects of porous tantalum. This study reviews the characteristics of porous tantalum-based biomaterials and the regulatory mechanisms on BMSCs, and discusses the feasibility of seeding BMSCs in porous tantalum-based biomaterials for tissue repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)