Article
Pharmacology & Pharmacy
Yuyu Zhu, Ning Wan, Xinni Shan, Guoliang Deng, Qiang Xu, Hui Ye, Yang Sun
Summary: Celastrol improves metabolic syndrome induced by high fat diet by targeting CAP1 and suppressing resistin-induced inflammation, suggesting its potential as a promising drug candidate for treating inflammatory metabolic diseases.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Physiology
Emilio Badoer
Summary: Leptin and resistin are cytokines that correlate with adiposity, and can influence sympathetic nerve activity in the brain, though they have contrasting effects. In conditions of metabolic dysfunction, interactions between these two hormones in the brain might lead to worse cardiovascular and metabolic complications.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Beatriz Fuentes-Romero, Alberto Munoz-Prieto, Jose J. Ceron, Maria Martin-Cuervo, Manuel Iglesias-Garcia, Escolastico Aguilera-Tejero, Elisa Diez-Castro
Summary: Obesity and its associated complications are increasing problems in humans and horses. This study found that plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to insulin dysregulation, similar to humans.
Article
Integrative & Complementary Medicine
Mi Mi Ko, Min Ho Cha, Jeeyoun Jung
Summary: The study revealed an association between Blood stasis syndrome (BSS) and metabolic syndrome, with significantly higher levels of resistin and insulin in patients with BSS. Resistin levels were correlated with symptoms of BSS in patients with metabolic syndrome.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Article
Health Care Sciences & Services
Carles Perpinan, Laia Bertran, Ximena Terra, Carmen Aguilar, Jessica Binetti, Miguel Lopez-Dupla, Anna Rull, Laia Reverte, Elena Yeregui, Frederic Gomez-Bertomeu, Joaquim Peraire, Teresa Auguet
Summary: This study investigates the feasibility of using baseline cytokines as early prognostic biomarkers for COVID-19, and analyzes the impact of comorbidities such as obesity or metabolic syndrome on the cytokine profile. The results reveal that resistin and IL-15 are associated with worse prognosis of COVID-19 and serve as the best early predictors for requiring invasive ventilation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tu T. Tran, Wei-Jan Huang, Heng Lin, Hsi-Hsien Chen
Summary: Obesity is a growing global concern that is associated with various diseases. In this study, the compound SW20.1 showed more effectiveness than the previously synthesized ST32db in reducing lipid accumulation in preadipocytes and inhibiting adipogenesis and lipogenesis. Through binding to the promoter region of resistin, SW20.1 exerted antiobesity effects by inhibiting resistin through the ATF3 pathway. The results from mice experiments also supported the therapeutic potential of SW20.1 for diet-induced obesity.
Article
Nutrition & Dietetics
Daniel A. de Luis, Katia Benito-Sendin, David Primo, Olatz Izaola
Summary: This study examines the association between the rs7139228 SNP of the RETN gene and metabolic syndrome. The results show that individuals carrying the A allele have higher levels of resistin, insulin, and insulin resistance, as well as a higher prevalence of metabolic syndrome.
NUTRICION HOSPITALARIA
(2023)
Article
Endocrinology & Metabolism
Pedro Cisternas, Camila Gherardelli, Joel Gutierrez, Paulina Salazar, Carolina Mendez-Orellana, G. William Wong, Nibaldo C. Inestrosa
Summary: The link between metabolic syndrome and brain function is not well understood, but adipokines, including adiponectin and resistin, may play a role. A high-fat diet-induced model revealed that adiponectin treatment improved cognitive functions and reduced AD pathology, while resistin exacerbated pathology.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Fulin Liu, Christine Rouault, Karine Clement, Wencan Zhu, Severine A. Degrelle, Marie-Aline Charles, Barbara Heude, Thierry Fournier
Summary: The study revealed a significant association between the C1431T variant of PPARγ and preeclampsia, while seven features including SNP variants, obesity, and smoking were identified as potential predictors of preeclampsia. Machine-learning algorithms, particularly the boost tree-based model, showed excellent predictive performance for preeclampsia, with high accuracy and AUC values in both training and testing sets.
Article
Cardiac & Cardiovascular Systems
Kirti Kirti, Shri Kant Singh
Summary: This study used secondary data from the National Nutrition Survey conducted in 2016-18 to identify a strong association between obesogenic diet and metabolic syndrome in Indian adolescents. The study utilized an unsupervised learning algorithm to determine possible clusters based on dietary patterns and analyzed the characteristics of each cluster. The findings suggest that controlling obesogenic dietary practices and addressing micronutrient deficiencies can prevent the burden of metabolic syndrome in early ages.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Immunology
Aminah M. Al-Awadi, Fabiola Lisa Saldhana, Zhansaya Bauyrzhanova, Rita Nemr, Naeema A. Mahmood, Wassim Y. Almawi
Summary: This study investigated the association of RETN gene polymorphisms with PCOS and found that rs34124816 and rs1423096 variants are associated with PCOS risk. The varied association of RETN gene variants with PCOS suggests an ethnic contribution to the RETN-PCOS association.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Celia Bauset, Ana Martinez-Aspas, Sara Smith-Ballester, Alicia Garcia-Vigara, Aitana Monllor-Tormos, Fawzi Kadi, Andreas Nilsson, Antonio Cano
Summary: Menopause leads to a decrease in estrogen levels and an increase in fat content, increasing the risk of metabolic syndrome. Nut ingestion may help reduce the risk of metabolic syndrome, especially by improving lipid and carbohydrate metabolism.
Article
Endocrinology & Metabolism
Han-Mo Yang, Joonoh Kim, Dasom Shin, Ju-Young Kim, Jihye You, Hyun-Chae Lee, Hyun-Duk Jang, Hyo-Soo Kim
Summary: This study found that resistin induces mitochondrial dysfunction by causing abnormal mitochondrial fission. The results suggest that the resistin-CAP1 complex could be a potential therapeutic target for the treatment of obesity-related metabolic diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Cell Biology
Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K. Mandal, Sirisha Senthil, Rohit C. Khanna, Meha Kabra, Inderjeet Kaur, Simon W. M. John, Subhabrata Chakrabarti, K. Saidas Nair
DISEASE MODELS & MECHANISMS
(2020)
Article
Ophthalmology
Rohit C. Khanna, Srinivas Marmamula, Maria Vittoria Cicinelli, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare E. Gilbert, Gullapalli Nageswara Rao
Summary: The incidence rate of pterygium is higher in rural populations, particularly among men, outdoor workers, individuals with low education levels, and those with lower body mass index (BMI). Greater exposure to ultraviolet light is a major contributing factor to the increased risk of developing pterygium in these populations, highlighting the need for preventive strategies.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Nagaraju Konda, Inderjeet Kaur, Prashant Garg, Subhabrata Chakrabarti, Mark D. P. Willcox
Summary: The study identified multiple associations between SNPs in TLR genes and keratitis in an Indian population, providing insights into the risk and molecular pathogenesis of the disease.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Rohit C. Khanna, Srinivas Marmamula, Pooja Pendri, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare Gilbert, Gullapalli N. Rao
Summary: The high incidence of visual loss in rural participants of APEDS III study is mainly attributed to cataract and uncorrected refractive errors. Significant independent risk factors for incident visual loss include increasing age, female gender, illiteracy, past or current smoking, and current alcohol use, with lower levels of education being an additional risk factor according to the USA definition.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Nikhil S. Choudhari, Rohit C. Khanna, Srinivas Marmamula, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare Gilbert, Gullapalli N. Rao
Summary: This study reported the long-term incidence of PACD in rural India, with female gender identified as a significant risk factor and myopia as a protective factor.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Pan, Daisuke Iejima, Mao Nakayama, Akiko Suga, Toru Noda, Inderjeet Kaur, Taraprasad Das, Subhabrata Chakrabarti, Robyn H. Guymer, Margaret M. DeAngelis, Megumi Yamamoto, Paul N. Baird, Takeshi Iwata
Summary: The study indicates that in AMD patients, the binding of the HTRA1 gene and the transcription factors Gtf2i-beta/delta leads to overexpression of HTRA1, causing CNV-like phenotype. A comparison with healthy controls showed a significant increase in HTRA1 concentration in the blood of AMD patients.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Ophthalmology
Muralidhar Ramappa, Uppal Gandhi, Sunita Chaurasia, Meha Kabra, Inderjeet Kaur, Ruchi Mittal, Dilip Kumar Mishra, Subhabrata Chakrabarti, Deepak P. Edward
Summary: This study reported the clinicopathological features of Peters anomaly in a child with nail-patella syndrome, identifying a novel missense heterozygous mutation in the LMX1B gene. This novel association has important implications for the research on NPS.
Article
Multidisciplinary Sciences
Satish Patnaik, Meenakshi Rai, Subhadra Jalali, Komal Agarwal, Akshay Badakere, Lavanya Puppala, Sushma Vishwakarma, Divya Balakrishnan, Padmaja K. Rani, Ramesh Kekunnaya, Preeti Patil Chhablani, Subhabrata Chakrabarti, Inderjeet Kaur
Summary: The study found that the severity of ROP in premature infants is correlated with MMP levels in tears, and the balance of anti-angiogenic and angiogenic factors in ROP eyes is regulated by MMPs along with opticin expression. Inhibiting MMP activity can reverse the decreased expression of opticin by microglial cells under hypoxia.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Paras Sehgal, Samatha Mathew, Ambily Sivadas, Arjun Ray, Jyoti Tanwar, Sushma Vishwakarma, Gyan Ranjan, K. Shamsudheen, Rahul C. Bhoyar, Abhishek Pateria, Elvin Leonard, Mukesh Lalwani, Archana Vats, Rajeev R. Pappuru, Mudit Tyagi, Saumya Jakati, Shantanu Sengupta, B. K. Binukumar, Subhabrata Chakrabarti, Inderjeet Kaur, Rajender K. Motiani, Vinod Scaria, Sridhar Sivasubbu
Summary: The study identified a novel vascular endothelial-associated lncRNA named VEAL2, which regulates endothelial permeability and function through interaction with PRKCB2, and is implicated in diabetic retinopathy.
Article
Multidisciplinary Sciences
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Helene Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borras, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Summary: Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. The authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.
NATURE COMMUNICATIONS
(2021)
Article
Ophthalmology
Srinivas Marmamula, Thirupathi Reddy Kumbham, Satya Brahmanandam Modepalli, Subhabrata Chakrabarti, Jill Elizabeth Keeffe
Summary: Despite the provision of free services, the uptake of eye care services in the elderly in residential care remains poor, with the main reason for non-compliance being lack of felt need for services. Elderly individuals who are independently mobile are more likely to utilize the services.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Nikhil S. Choudhari, Rohit C. Khanna, Srinivas Marmamula, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare Gilbert, Gullapalli N. Rao
Summary: This study aimed to report the 15-year incidence rate of pseudo-exfoliation (PXF), PXF glaucoma, and regional variation among rural participants in Andhra Pradesh, India. The study found significant regional variation in the incidence of PXF in South India. It was associated with increasing age and study site.
Article
Microbiology
Nagaraju Konda, Subhabrata Chakrabarti, Prashant Garg, Mark D. P. Willcox
Summary: The study revealed the associations between SNPs in IL1B and CXCL8 with the risk of developing keratitis, as well as relationships between SNPs and clinical measures of keratitis. Further research in different populations is needed to explore potential ethnic differences in SNP frequencies and their association with keratitis.
Article
Ophthalmology
Deepika C. Parameswarappa, Subhadra Jalali, Srinivas Marmamula, Ramya Natarajan, Asha L. Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Rohit C. Khanna
Summary: This study aimed to assess the incidence, visual impairment, and blindness caused by retinitis pigmentosa (RP) in a rural southern Indian population. A longitudinal cohort study was conducted on participants with RP from the Andhra Pradesh Eye Disease Study (APEDS) cohorts I and III. The results showed that RP is a prevalent disease in southern India, highlighting the need for appropriate strategies to prevent and treat this condition.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Manjushree Bhate, Sakshi Lalwani, Subhabrata Chakrabarti
Summary: This study observed significant variations in phenotypic presentations among siblings with oculocutaneous albinism. Differences were found in visual acuity, refractive status, and nystagmus between siblings.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
