Journal
JOURNAL OF BIOSCIENCES
Volume 34, Issue 4, Pages 523-528Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-009-0071-x
Keywords
Differentiation; EMT; pancreas; plasticity; progenitor
Categories
Funding
- NCCS
- Department of Biotechnology [BT/PR7975/Med/14/1211/2006]
- UK-India Research Initiative [DST/INT/UKIERI/SA/P-4/2008]
- Council of Scientific and Industrial Research (CSIR), New Delhi
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Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.
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