Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 6, Pages 925-931Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.158358
Keywords
nerve regeneration; curcumin; neurons; HIV-1 gp120 V3 loop; plasticity; HIV-associated neurocognitive disorders; output/input curve; long-term potentiation; excitatory postsynaptic potential; paired-pulse facilitation; Ca2+; synaptosome; NSFC grants; neural regeneration
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Funding
- National Natural Science Foundation of China [81171134, 81471235]
- Introducing Talents of Discipline to Universities [B14036]
- College Students' Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University Challenge Cup [(2013)27, (2014)16]
- College Students' Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University in China [201410559079, 1055914162, CX14261]
- National Basic Research Program of China (973 Program) [2011CB707501]
- Science and Technology Foundation of Guangdong Province in China [2010B030700016]
- Natural Science Foundation of Guangdong Province in China [2014A030313360]
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Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.
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