High-throughput screening of improved protease inhibitors using a yeast cell surface display system and a yeast cell chip

Protease-targeted inhibitors have been promising pharmaceuticals. Here, we combined a yeast cell surface display system with a yeast cell chip for the high-throughput screening of protease inhibitors, and succeeded in improving the activity of a protease inhibitor. (C) 2010, The Society for Biotechnology, Japan. All rights reserved.