Journal
JOURNAL OF BIOPHOTONICS
Volume 8, Issue 1-2, Pages 94-101Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201300189
Keywords
endometriosis; optical imaging; photoacoustic microscopy; biomedical optics
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Funding
- National Natural Science Foundation of China [61078073]
- National 973 Program of China [2011CB707502]
- Scientific Project Design from Young and Middle-aged Researcher of Peking Union Medical College Hospital [pumch-2013-028]
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Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM.
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