Article
Biochemistry & Molecular Biology
Takashi Maeda, Fumiko Sekiguchi, Kenji Mitani, Ryosuke Yamagata, Maho Tsubota, Shigeru Yoshida, Atsufumi Kawabata
Summary: Irregular axon regeneration or remodeling may contribute to neuropathic pain after peripheral nerve trauma. PGE2, in combination with IBMX, promotes neuritogenesis and neurite outgrowth in mouse DRG neurons, involving the EP4 receptor/PKA/Cav3.2 pathway. Morphine, an MOR agonist, suppresses PGE2-induced neuritogenesis and/or neurite outgrowth, suggesting its potential in preventing neuropathic pain.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Moez Eid, Stanislav Rodkin, Maria Pitinova, Svetlana Demyanenko
Summary: This study investigated the expression and localization of E2F1 after axonal injury and found that axotomy increased the expression of E2F1 in neurons. The study also suggested that E2F1 and downstream targets could be potential molecular targets for the development of neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Wen-Long Qiao, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: This study found a functional interaction between LPA and P2X3 receptors in rat sensory neurons. LPA enhanced the activity of P2X3 receptors through activation of the LPA(1) receptor and PKC pathway, exacerbating nociceptive behaviors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Soju Seki, Yoshihiro Kitaoka, Sou Kawata, Akira Nishiura, Toshihiro Uchihashi, Shin-ichiro Hiraoka, Yusuke Yokota, Emiko Tanaka Isomura, Mikihiko Kogo, Susumu Tanaka
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of motor neurons, with emerging evidence suggesting involvement of sensory neurons. Clinical research has shown sensory symptoms and abnormal nerve conduction in ALS patients, while preclinical research has identified genetic abnormalities in both sensory and motor neurons. This review highlights the potential of targeting sensory neuron abnormalities in ALS for new therapies.
Article
Agricultural Engineering
Xiuye Wei, Xinlin Zhao, Songhua Long, Qingmei Xiao, Yuan Guo, Caisheng Qiu, Huajiao Qiu, Yufu Wang
Summary: This study investigated the effects of different LED light qualities on the growth and cannabinoid synthesis of hemp. Results showed that LED2 and LED5 could effectively promote hemp growth and increase CBD content. LED2 and LED5 may be good choices for indoor farming of hemp targeted for higher CBD yield.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Multidisciplinary Sciences
Rui Feng, Vishnu Muraleedharan Saraswathy, Mayssa H. Mokalled, Valeria Cavalli
Summary: Sensory neurons in the dorsal root ganglia (DRG) relay sensory information and undergo regenerative processes with the help of glial and immune cells. Macrophages in the DRG play a crucial role in promoting axon regeneration, and they possess self-renewal capacity. Through single-cell transcriptomics and communication simulation, it was found that DRGMacs express neuroprotective and glioprotective ligands and communicate with satellite glial cells. This heterogeneity and function of DRGMacs have potential implications for nerve injury treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Manon Bohic, Aman Upadhyay, Jaclyn T. Eisdorfer, Jessica Keating, Rhiana C. Simon, Brandy A. Briones, Chloe Azadegan, Hannah D. Nacht, Olisemeka Oputa, Alana M. Martinez, Bridget N. Bethell, Mark A. Gradwell, Peter Romanienko, Matt S. Ramer, Garret D. Stuber, Victoria E. Abraira
Summary: Improvements in expression profiling of neuronal tissues allow for the analysis of finer subgroups of neurons. This study establishes a new workflow for dissecting adult spinal function based on developmental lineages. A brain-sparing mouse line is generated to restrict gene manipulation to the spinal cord.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zhiqiang Pan, Shibin Du, Kun Wang, Xinying Guo, Qingxiang Mao, Xiaozhou Feng, Lina Huang, Shaogen Wu, Bailing Hou, Yun-Juan Chang, Tong Liu, Tong Chen, Hong Li, Thomas Bachmann, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: The downregulation of DS-lncRNA in nerve injury-induced neuropathic pain affects the expression of G9a protein and RALY, leading to changes in opioid receptor and Kcna2 expression, which exacerbates pain symptoms.
Article
Cell Biology
Hyun-jeong Pyo, Xue An, Hana Cho
Summary: This study identifies a new pathway for the modulation of TRPA1 and TRPV1 channels, which are involved in inflammatory and neuropathic pain. The findings show that endogenous anti-inflammatory lipid mediators can selectively inhibit the activity of these channels through specific signaling pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jia-Wei Hao, Ting-Ting Liu, Chun-Yu Qiu, Xue-Mei Li, Wen-Long Qiao, Qing Li, Qing-Rui Qin, Wang-Ping Hu
Summary: This study revealed a novel mechanism by which Resolvin D2 (RvD2) exerts its analgesic effects by targeting P2X3 receptors. RvD2 inhibited P2X3 receptors in rat primary sensory neurons through GPR18, PTX-sensitive G alpha(i/o)-proteins, and intracellular cAMP/PKA signaling, leading to pain relief.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Immunology
Antoine Millet, Nicholas Jendzjowsky
Summary: Sensory neurons cooperate with barrier tissues and resident immune cells to form a significant aspect of defensive strategies in concert with the immune system. This assembly of neuroimmune cellular units is exemplified across evolution from early metazoans to mammalian life. Sensory neurons possess the capability to detect pathogenic infiltrates at barrier surfaces and unleash specific cell signaling, trafficking, and defensive reflexes to amplify the alerting response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yuhao Xu, Zongsheng Jiang, Xiaowei Chen
Summary: Paclitaxel is a widely used chemotherapeutic agent, but its use often leads to severe neuropathic pain that is difficult to manage. The mechanisms underlying paclitaxel-induced neuropathic pain are still unclear, but evidence suggests correlations with ion channels, neuroinflammation, and mitochondrial damage.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Ristiawan Muji Laksono, Taufiq Agus Siswagama, Fa'urinda Riam Prabu Nery, Walter van der Weegen, Willy Halim
Summary: Experimental study shows that 2 Hz PRF has less physiological impact on healthy neurons compared to 4 Hz, making it a preferred frequency for neuron-targeted therapy in clinical applications.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Neurosciences
Jia-Wei Hao, Wen-Long Qiao, Qing Li, Shuang Wei, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: In this study, it was found that the α2A-AR agonist DEX has an analgesic effect by activating peripheral α2A-AR and suppressing P2X3 receptor activity. This effect is mediated through intracellular G(i/o) proteins and cAMP signaling pathways in neurons.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Daria Mamaeva, Zhour Jazouli, Mattia L. DiFrancesco, Nejla Erkilic, Gregor Dubois, Cecile Hilaire, Isabelle Meunier, Hassan Boukhaddaoui, Vasiliki Kalatzis
Summary: This study investigates the role of different ion channels in human-induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) functions. The research demonstrates the importance of various channels in processes such as phagocytosis and vascular endothelial growth factor (VEGF) secretion, highlighting the potential of hiPSC-derived RPE as a model for studying RPE functions.
Review
Orthopedics
J. Braga Silva, B. L. M. Leal, G. A. Magnus, V de Souza Stanham, R. Mattiello, C. G. Wolff
Summary: This study compared nerve conduits and nerve grafts for peripheral nerve regeneration, and found that in patients over 40 years old, nerve grafting seemed to have a better effect on improving sensation and motor function.
HAND SURGERY & REHABILITATION
(2021)
Review
Orthopedics
J. Braga Silva, C. V. Busnello, A. S. Becker, C. A. Moriguchi, R. O. de Melo, V. B. Waichel
Summary: This study conducted a systematic review to assess the clinical applicability of end-to-side neurorrhaphy in peripheral nerve reconstruction, and found that clinical studies lack scientific evidence on this technique.
HAND SURGERY & REHABILITATION
(2022)
Article
Orthopedics
B. Coulet, F. Coroian, M. Chammas, I Laffont
Summary: In addition to motor deficits, central nervous system disorders can also cause spasticity and contractures, making assessment and treatment more complex. Tendon transfers in this population have limited indications and should be combined with other procedures. We propose a method to evaluate these patients using a score (INOM) that considers prognostic factors and surgical corrections. Nerve blocks and botulinum toxin injections are essential tools for analysis. The surgical strategy can be determined based on the INOM score. We describe the indications and relative role of tendon transfers among other techniques for each joint.
HAND SURGERY & REHABILITATION
(2022)
Article
Orthopedics
B. Coulet, M. Chammas
Summary: Elbow extension palsy is generally well tolerated, as it can be alleviated by gravity when standing up. Active restoration of elbow extension improves hand positioning and allows for certain activities. Nerve transfers may restore triceps brachii function in early surgery cases, and palliative tendon transfers are the reference technique when nerve transfers are not possible. Elbow extension is essential for wheelchair users to position the hand and activate transferable muscles. Evaluating the potential muscles and considering contracture and deformity are important in upper limb reconstructive surgery.
HAND SURGERY & REHABILITATION
(2022)
Review
Orthopedics
Jefferson Braga Silva, Michel Chammas, Pierre-Emmanuel Chammas, Rubens Andrade, Bruno Hochhegger, Bruna Leiria Mereje Leal
Summary: This study conducted a systematic review to analyze the applicability of magnetic resonance neurography in peripheral nerve injuries. It found that MRI has various advantages for diagnosis, surgery, and postoperative monitoring, highlighting the need for implementing new imaging techniques in this field.
HAND SURGERY & REHABILITATION
(2022)
Article
Orthopedics
A. Cambon-Binder, M. Chammas, B. Coulet, C. Lazerges
Summary: Ulnar nerve paralysis has various clinical presentations and can result in loss of hand strength and impaired finger functions. Palliative surgery plays an important role when nerve repair techniques are not suitable, aiming to reinforce metacarpophalangeal flexion and stabilize the thumb's interphalangeal joint.
HAND SURGERY & REHABILITATION
(2022)
Article
Orthopedics
O. Bozon, M. Chammas, B. Degeorge, F. Coroian, I. Lafont, B. Coulet
Summary: Total wrist arthrodesis is an effective therapeutic option for severe wrist flexion deformities caused by spasticity. This study evaluated the clinical and anatomical results of wrist shortening arthrodesis using a classic volar plate in the dorsal position, and found that it provided good anatomical results and high patient satisfaction.
HAND SURGERY & REHABILITATION
(2022)
Article
Orthopedics
Charline Garcon, Benjamin Degeorge, Bertrand Coulet, Cyril Lazerges, Michel Chammas
Summary: Perilunate injuries in the wrist often result in functional sequelae and long-term radiographic changes, despite optimal treatment. Patient's age and the magnitude of lunate displacement are important predictors for prognosis.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Review
Orthopedics
Pierre-Emmanuel Chammas, Nawale Hadouiri, Michel Chammas, Sonia Ramos -Pascual, Patrick Stirling, Luca Nover, Shahnaz Klouche
Summary: This study compared the clinical results, complications, conversion rate to total wrist arthrodesis, and progression to osteoarthritis of proximal row carpectomy (PRC) versus scaphoid excision followed by four corner arthrodesis (4CA) in the medium and long term. The results showed that PRC had significantly better range of motion and lower complication rates compared to 4CA. However, there were no significant differences in other parameters. The analysis of arthritis progression was inconclusive due to lack of data.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Article
Cell & Tissue Engineering
Carla Sanjurjo-Soriano, Nejla Erkilic, Krishna Damodar, Hassan Boukhaddaoui, Michalitsa Diakatou, Marcela Garita-Hernandez, Daria Mamaeva, Gregor Dubois, Zhour Jazouli, Carla Jimenez-Medina, Olivier Goureau, Isabelle Meunier, Vasiliki Kalatzis
Summary: This study demonstrates the importance of supplemented media for culturing retinal organoids and shows that retinoic acid plays a crucial role in inducing rod cell fate and enhancing the organization of the photoreceptor layer.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Orthopedics
Jefferson Braga Silva, Alice Scalzilli Becker, Bruna Leiria Mereje Leal, Catarina Vellinho Busnello
Summary: The purpose of this study was to review the evidence on direct peripheral nerve repair techniques and determine if there are any differences in outcomes. The results showed no significant difference between different techniques. Further research is needed to understand the best treatment methods for peripheral nerve injuries.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Engineering, Electrical & Electronic
Lucas Martin Wisniewski, Jean-Michel Bec, Guillaume Boguszewski, Abdoulaye Gamatie
Summary: This paper discusses the application of edge computing in the Internet of Things and introduces embedded systems that enable energy-efficient execution of machine learning algorithms. It also surveys mainstream embedded computing devices for low-power IoT and edge computing, and introduces the innovative smart edge computing system CYSmart.
JOURNAL OF LOW POWER ELECTRONICS AND APPLICATIONS
(2022)
Article
Orthopedics
Hugo Barret, Nicolas Bonnevialle, Pierre-Emmanuel Chammas, Olivier Bozon, Michel Chammas, Cyril Lazerges, Bertrand Coulet, Elie El Kayem
Summary: The study aimed to analyze the scapulohumeral arch in primary glenohumeral osteoarthritis with an uninjured cuff and determine whether posterior humeral subluxation influences the Moloney line. The results showed that incongruity of the Moloney line was more frequent in shoulders with type B glenoids, indicating a possible rotator cuff injury or posterior glenohumeral subluxation.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Chemistry, Medicinal
Benoit Gautier, Melanie Fore Jacquard, Sophie Guelfi, Scarlette Abbou, Elisa Gonzalez, Jade Berthelot, Hassan Boukhaddaoui, Aurelien Lebrun, Baptiste Legrand, Nicolas Tricaud, Nicolas Inguimbert
Summary: This study investigates the binding mechanism of VDAC, the most abundant protein on the outer mitochondrial membrane, to HK and enhances its ability to prevent peripheral nerve demyelination by modifying peptides. The findings provide new insights into the interaction between VDAC and HK, potentially leading to the development of therapeutic compounds for demyelinating peripheral neuropathies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
