Journal
JOURNAL OF BIOPHOTONICS
Volume 7, Issue 5, Pages 281-285Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201200220
Keywords
time resolved fluorescence spectroscopy; fluorescence lifetime imaging; intravascular ultrasound (IVUS); intravascular catheter; atherosclerosis
Categories
Funding
- NIH Grant [R01 HL 67377]
Ask authors/readers for more resources
Fluorescence lifetime technique has demonstrated potential for analysis of atherosclerotic lesions and for complementing existing intravascular imaging modalities such as intravascular ultrasound (IVUS) in identifying lesions at high risk of rupture. This study presents a multimodal catheter system integrating a 40 MHz commercial IVUS and fluorescence lifetime imaging (FLIm) using fast helical motion scanning (400 rpm, 0.75 mm/s), able to acquire in vivo in pulsatile blood flow the autofluorescence emission of arterial vessels with high precision (5.08 +/- 0.26 ns mean average lifetime over 13 scans). Co-registered FLIm and IVUS data allowed 3D visualization of both biochemical and morphological vessel properties. Current study supports the development of clinically compatible intravascular diagnostic system integrating FLIm and demonstrates, to our knowledge, the first in vivo intravascular application of a fluorescence lifetime imaging technique. ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available